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公开(公告)号：US20240076645A1
公开(公告)日：2024-03-07
申请号：US18068004
申请日：2022-12-19
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Sarah Rowe , Yves Millet
CPC分类号： C12N9/88 , A61K35/74 , A61K35/741 , A61P7/00 , C12N9/78 , C12Q1/527 , C12Y104/03002 , C12Y403/01024 , G01N2333/988 , G01N2560/00
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
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2.发明公开公开(公告)号：US20230226122A1
公开(公告)日：2023-07-20
申请号：US17879559
申请日：2022-08-02
发明人： Dean Falb , Jonathan W. Kotula , Vincent M. Isabella , Paul F. Miller , Suman Machinani , Saurabh Saha , Adam B. Fisher , Yves Millet , Ning Li , Jose M. Lora
IPC分类号： A61K35/74 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/54 , C07K14/57 , C07K14/705 , C07K16/28 , C12N9/26 , C12N15/62 , C12N15/74
CPC分类号： A61K35/74 , C07K14/53 , C07K14/57 , C07K14/521 , C07K14/525 , C07K14/5434 , C07K14/5443 , C07K14/70575 , C07K14/70596 , C07K16/2818 , C12N9/2408 , C12N15/62 , C12N15/74 , A61K33/243 , C07K2317/622 , C07K2319/21 , C12N2840/002 , C12Y302/01003 , C12Y302/01035
摘要： Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
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公开(公告)号：US20230063093A1
公开(公告)日：2023-03-02
申请号：US17819086
申请日：2022-08-11
发明人： Dylan Alexander Carlin , Vincent M. Isabella , Jonathan McMurry , Theodore Carlton Moore, III , Mylene Perreault , Seth Ritter , Nathan Schmidt , Mark Simon
IPC分类号： C12N15/52 , A61K35/741 , C12N15/70 , C12N9/88 , C07K14/245
摘要： The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
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4.发明授权公开(公告)号：US11471494B2
公开(公告)日：2022-10-18
申请号：US16474383
申请日：2018-01-05
发明人： Dean Falb , Jonathan W. Kotula , Vincent M. Isabella , Paul F. Miller , Suman Machinani , Saurabh Saha , Adam B. Fisher , Yves Millet , Ning Li , Jose M. Lora
IPC分类号： A61K35/74 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/54 , C07K14/57 , C07K14/705 , C07K16/28 , C12N9/26 , C12N15/62 , C12N15/74 , A61K33/243
摘要： Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
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公开(公告)号：US11291693B2
公开(公告)日：2022-04-05
申请号：US15738174
申请日：2016-06-24
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Sarah Rowe , Yves Millet , Adam Fisher
IPC分类号： A61K35/74 , A23L33/135 , A61P3/10 , A61K9/00 , A61K35/741 , C12N15/52 , A61K35/747 , A61K35/744 , A61K35/745 , A61K35/00
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of attenuating metabolic diseases are disclosed.
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公开(公告)号：US20200246394A1
公开(公告)日：2020-08-06
申请号：US16788458
申请日：2020-02-12
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Yves Millet , Sarah Rowe
IPC分类号： A61K35/74 , C07K14/195 , A61K35/741 , C12N9/06 , C07K14/245 , C12N15/70 , C12N9/88 , A61K39/02
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
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7.发明申请公开(公告)号：US20190336544A1
公开(公告)日：2019-11-07
申请号：US16474383
申请日：2018-01-05
发明人： Dean Falb , Jonathan W. Kotula , Vincent M. Isabella , Paul F. Miller , Suman Machinani , Saurabh Saha , Adam B. Fisher , Yves Millet , Ning Li , Jose M. Lora
IPC分类号： A61K35/74 , C07K16/28 , C07K14/52 , C07K14/53 , C07K14/525 , C12N9/26 , C07K14/54 , C07K14/57 , C07K14/705 , C12N15/74 , C12N15/62
摘要： Genetically programmed microorganisms, such as bacteria or virus, pharmaceutical compositions thereof, and methods of modulating and treating cancers are disclosed.
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公开(公告)号：US20180320161A1
公开(公告)日：2018-11-08
申请号：US15775936
申请日：2016-11-16
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Sarah Rowe , Yves Millet
IPC分类号： C12N9/88 , A61K35/741 , C12Q1/527 , C12N9/78 , A61P7/00
CPC分类号： C12N9/88 , A61K35/741 , A61P7/00 , C12N9/78 , C12Q1/527 , C12Y403/01024 , G01N2333/988 , G01N2560/00
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of modulating and treating diseases associated with hyperphenylalaninemia are disclosed.
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公开(公告)号：US20230043588A1
公开(公告)日：2023-02-09
申请号：US17835601
申请日：2022-06-08
发明人： Dean Falb , Vincent M. Isabella , Jonathan W. Kotula , Paul F. Miller , Yves Millet , Adam Fisher
IPC分类号： C12N15/70 , C12N9/02 , C12N9/12 , A61K35/741 , A61K38/20 , A61K38/26 , A61K38/44 , A61K31/19 , A61K31/198
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
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公开(公告)号：US20210161976A1
公开(公告)日：2021-06-03
申请号：US16074559
申请日：2017-02-03
发明人： Paul F. Miller , Vincent M. Isabella , Jonathan W. Kotula , Dean Falb , Adam B. Fisher , Yves Millet , Ning Li
IPC分类号： A61K35/747 , A61K35/745 , C12P7/52 , C12P7/54 , C12N15/74 , C12N15/70 , A61P1/00
摘要： Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
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