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公开(公告)号：US20220348933A1
公开(公告)日：2022-11-03
申请号：US17621214
申请日：2020-06-19
发明人： Patrick Boyle , Dylan Alexander Carlin , Rishi Jain , Ryan Putman , Laura Stone , Alex C. Tucker , Kolea Zimmerman
摘要： Provided in this disclosure, in some embodiments, are methods and compositions for treating maple syrup urine disease (MSUD) and other conditions characterized by excessive branched-chain amino acids.
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2.发明公开公开(公告)号：US20240102024A1
公开(公告)日：2024-03-28
申请号：US18524651
申请日：2023-11-30
发明人： Dylan Alexander Carlin , Vincent M. Isabella , Jonathan McMurry , Theodore Carlton Moore, III , Mylene Perreault , Nathan Schmidt , Mark Simon
IPC分类号： C12N15/52 , A61K35/741 , C07K14/245 , C12N9/88 , C12N15/70
CPC分类号： C12N15/52 , A61K35/741 , C07K14/245 , C12N9/88 , C12N15/70 , C12Y401/01057 , C12Y404/01011
摘要： The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
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公开(公告)号：US20230063093A1
公开(公告)日：2023-03-02
申请号：US17819086
申请日：2022-08-11
发明人： Dylan Alexander Carlin , Vincent M. Isabella , Jonathan McMurry , Theodore Carlton Moore, III , Mylene Perreault , Seth Ritter , Nathan Schmidt , Mark Simon
IPC分类号： C12N15/52 , A61K35/741 , C12N15/70 , C12N9/88 , C07K14/245
摘要： The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
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公开(公告)号：US11859189B2
公开(公告)日：2024-01-02
申请号：US17819086
申请日：2022-08-11
发明人： Dylan Alexander Carlin , Vincent M. Isabella , Jonathan McMurry , Theodore Carlton Moore, III , Mylene Perreault , Nathan Schmidt , Mark Simon
IPC分类号： C12N9/88 , C12N15/52 , A61K35/741 , C12N15/70 , C07K14/245
CPC分类号： C12N15/52 , A61K35/741 , C07K14/245 , C12N9/88 , C12N15/70 , C12Y401/01057 , C12Y404/01011
摘要： The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.
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公开(公告)号：US20220362311A1
公开(公告)日：2022-11-17
申请号：US17621121
申请日：2020-06-19
发明人： Ning Li , Jian-Rong Gao , Philippa Jane Reeder Morrison , Christopher George Bergeron , Dylan Alexander Carlin , Laura K. Stone , Alex C. Tucker , Patrick M. Boyle
IPC分类号： A61K35/747 , A61K35/741 , A61K35/745 , A61K35/742 , A61K35/744 , A61P13/02 , C12N1/20 , C12N15/52 , C12N15/70
摘要： The present disclosure provides recombinant bacterial cells that have been engineered with genetic circuitry which allow the recombinant bacterial cells to sense a patients internal environment and respond by turning an engineered metabolic pathway on or off. When turned on, the recombinant bacterial cells complete all of the steps in a metabolic pathway to achieve a therapeutic effect in a host subject. These recombinant bacterial cells are designed to drive therapeutic effects throughout the body of a host from a point of origin of the microbiome. Specifically, the present disclosure provides recombinant bacterial cells comprising a heterologous gene encoding an improved leucine catabolism enzyme with higher activity and/or specificity for leucine over other branched chain amino acids, such as isoleucine or valine. The disclosure further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders involving the catabolism of leucine, isoleucine, and/or valine using the pharmaceutical compositions disclosed herein.
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公开(公告)号：US20220307060A1
公开(公告)日：2022-09-29
申请号：US17690446
申请日：2022-03-09
发明人： Kim Cecelia Anderson , Elena Brevnova , Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Matthew McMahon , Massimo Merighi , Gabriel Rodriguez , Emily E. Wrenbeck
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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公开(公告)号：US20220195472A1
公开(公告)日：2022-06-23
申请号：US17665441
申请日：2022-02-04
发明人： Kim Cecelia Anderson , Elena Brevnova , Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Massimo Merighi , Gabriel Rodriguez , Emily E. Wrenbeck
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro.
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公开(公告)号：US20240141308A1
公开(公告)日：2024-05-02
申请号：US18283688
申请日：2022-04-15
CPC分类号： C12N9/16 , A61K38/465 , C12Y301/08001
摘要： Aspects of the disclosure relate to phosphotriesterase (PTE) enzymes and PTE-related (PTER) enzymes and their use in hydrolyzing OPNAs.
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公开(公告)号：US20220306999A1
公开(公告)日：2022-09-29
申请号：US17636351
申请日：2020-08-18
发明人： Kim Cecelia Anderson , Dylan Alexander Carlin , Nicholas Flores , Katrina Forrest , Ramya L. Prathuri , Gabriel Rodriguez , Michelle Spencer
摘要： The disclosure relates to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro comprising the use of disclosed prenyltransferase variants.
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公开(公告)号：US20240110206A1
公开(公告)日：2024-04-04
申请号：US18031522
申请日：2021-10-12
发明人： Dylan Alexander Carlin , Brian Carvalho , Nicholas Flores , Katrina Forrest , Gabriel Rodriguez , Nathan W. Schmidt , Michelle Spencer
CPC分类号： C12P7/42 , C12N9/1029 , C12N9/1085 , C12N15/62 , C12N15/81 , C12Y203/01206 , C12Y205/0101
摘要： Aspects of the disclosure relate to biosynthesis of cannabinoids and cannabinoid precursors in recombinant cells and in vitro. Specifically, the disclosure is directed to a prenyltransferase variant, a chimeric prenyltransferase comprising one or more portions of at least two different prenyltransferase proteins, and a fusion polypeptide comprising a CBG-type producing prenyltransferase and farnesyl pyrophosphate synthase.
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