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    Method For Testing Efficacy Of Treatment Of Neurologic Disorders
    1.
    发明申请
    Method For Testing Efficacy Of Treatment Of Neurologic Disorders 有权
    用于测试神经障碍治疗功效的方法

    公开(公告)号：US20110083200A1

    公开(公告)日：2011-04-07

    申请号：US12993480

    申请日：2009-06-03

    申请人： Sun-Yung Jung ,  Mary Birchler

    发明人： Sun-Yung Jung ,  Mary Birchler

    IPC分类号： A61K49/00

    CPC分类号： A01K1/031 ,  A01K67/02 ,  A61K49/0008

    摘要： The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with cognitive dysfunction and, in particular, dementia; schizophrenia; anxiety; depression; and pain using a rodent behavioral assay, wherein the method is useful in testing compositions useful in the modulation, amelioration, prevention, or treatment of dementia using a non-human animal carrying at least a transgene for human amyloid-beta protein or human tau and transgenes causing the elevated production of the human amyloid-beta protein in the animal as compared to nontrans genie animals of the same genetic background and the behavior is a nesting behavior.

    摘要翻译： 本发明的方法可用于评估用于治疗包括与认知功能障碍相关的神经或神经变性疾病，特别是痴呆的神经疾病的药物组合物; 精神分裂症 焦虑; 萧条; 和使用啮齿动物行为测定法的疼痛，其中所述方法可用于测试使用至少携带人淀粉样蛋白-β蛋白或人tau的转基因的非人动物进行调节，改善，预防或治疗痴呆的组合物，以及 与相同遗传背景的非转基因动物相比，导致动物中人淀粉样蛋白β蛋白产生升高的转基因是嵌套行为。

    Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau
    2.
    发明授权
    Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau 有权
    通过给予表达APP，早老素或tau的突变形式的三重转基因小鼠来鉴定治疗阿尔茨海默病相关的分选行为的药剂

    公开(公告)号：US08933295B2

    公开(公告)日：2015-01-13

    申请号：US12993480

    申请日：2009-06-03

    申请人： Sun-Yung Jung ,  Mary Birchler

    发明人： Sun-Yung Jung ,  Mary Birchler

    IPC分类号： A01K67/027 ,  A01K1/03 ,  A01K67/02 ,  A61K49/00

    CPC分类号： A01K1/031 ,  A01K67/02 ,  A61K49/0008

    摘要： The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with cognitive dysfunction and, in particular, dementia; schizophrenia; anxiety; depression; and pain using a rodent behavioral assay, wherein the method is useful in testing compositions useful in the modulation, amelioration, prevention, or treatment of dementia using a non-human animal carrying at least a transgene for human amyloid-beta protein or human tau and transgenes causing the elevated production of the human amyloid-beta protein in the animal as compared to nontransgenic animals of the same genetic background and the behavior is a nesting behavior.

    摘要翻译： 本发明的方法可用于评估用于治疗包括与认知功能障碍相关的神经或神经变性疾病，特别是痴呆的神经疾病的药物组合物; 精神分裂症 焦虑; 萧条; 和使用啮齿动物行为测定法的疼痛，其中所述方法可用于测试使用至少携带人淀粉样蛋白-β蛋白或人tau的转基因的非人动物进行调节，改善，预防或治疗痴呆的组合物，以及 与相同遗传背景的非转基因动物相比，导致动物中人淀粉样蛋白-β蛋白产生升高的转基因是嵌套行为。