发明授权
US08933295B2 Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau
有权
通过给予表达APP，早老素或tau的突变形式的三重转基因小鼠来鉴定治疗阿尔茨海默病相关的分选行为的药剂
- 专利标题： Identifying agents to treat alzheimer's disease-related decreased sorting behavior by administration to a triple transgenic mouse expressing mutant forms of APP, presenilin or tau
- 专利标题（中）： 通过给予表达APP，早老素或tau的突变形式的三重转基因小鼠来鉴定治疗阿尔茨海默病相关的分选行为的药剂
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申请号： US12993480申请日： 2009-06-03
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公开(公告)号： US08933295B2公开(公告)日： 2015-01-13
- 发明人: Sun-Yung Jung , Mary Birchler
- 申请人： Sun-Yung Jung , Mary Birchler
- 申请人地址： US PA Horsham
- 专利权人： Janssen Biotech, Inc.
- 当前专利权人： Janssen Biotech, Inc.
- 当前专利权人地址： US PA Horsham
- 代理商 Brian C. Carey
- 国际申请： PCT/US2009/046073 WO 20090603
- 国际公布： WO2009/155133 WO 20091223
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; A01K1/03 ; A01K67/02 ; A61K49/00
摘要：
The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with cognitive dysfunction and, in particular, dementia; schizophrenia; anxiety; depression; and pain using a rodent behavioral assay, wherein the method is useful in testing compositions useful in the modulation, amelioration, prevention, or treatment of dementia using a non-human animal carrying at least a transgene for human amyloid-beta protein or human tau and transgenes causing the elevated production of the human amyloid-beta protein in the animal as compared to nontransgenic animals of the same genetic background and the behavior is a nesting behavior.
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