公开(公告)号：US20110083200A1

公开(公告)日：2011-04-07

申请号：US12993480

申请日：2009-06-03

申请人： Sun-Yung Jung ,  Mary Birchler

发明人： Sun-Yung Jung ,  Mary Birchler

IPC分类号： A61K49/00

CPC分类号： A01K1/031 ,  A01K67/02 ,  A61K49/0008

摘要： The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with cognitive dysfunction and, in particular, dementia; schizophrenia; anxiety; depression; and pain using a rodent behavioral assay, wherein the method is useful in testing compositions useful in the modulation, amelioration, prevention, or treatment of dementia using a non-human animal carrying at least a transgene for human amyloid-beta protein or human tau and transgenes causing the elevated production of the human amyloid-beta protein in the animal as compared to nontrans genie animals of the same genetic background and the behavior is a nesting behavior.

摘要翻译： 本发明的方法可用于评估用于治疗包括与认知功能障碍相关的神经或神经变性疾病，特别是痴呆的神经疾病的药物组合物; 精神分裂症 焦虑; 萧条; 和使用啮齿动物行为测定法的疼痛，其中所述方法可用于测试使用至少携带人淀粉样蛋白-β蛋白或人tau的转基因的非人动物进行调节，改善，预防或治疗痴呆的组合物，以及 与相同遗传背景的非转基因动物相比，导致动物中人淀粉样蛋白β蛋白产生升高的转基因是嵌套行为。

公开(公告)号：US20140227259A1

公开(公告)日：2014-08-14

申请号：US14239196

申请日：2012-08-13

申请人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

发明人： Claire Ashman ,  Mary Birchler ,  Rudolf M.T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

IPC分类号： C07K16/42

摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

摘要翻译： 本公开涉及具有降低与先前存在的抗体结合的能力的修饰的蛋白质和肽。 这种修饰的蛋白质/肽分子可以包含C-末端添加，延伸或标签和/或某些氨基酸取代。 这样的修饰分子（例如，融合物和缀合物）包含蛋白质，肽，抗原结合分子，抗体或抗体片段，例如单可变结构域。 本公开还涉及包含这种修饰的C-末端延伸和/或氨基酸取代的分子的组合物的用途和制剂，以及这些的生产和表达方法。

公开(公告)号：US10808040B2

公开(公告)日：2020-10-20

申请号：US14239196

申请日：2012-08-13

申请人： Claire Ashman ,  Mary Birchler ,  Rudolf M. T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

发明人： Claire Ashman ,  Mary Birchler ,  Rudolf M. T. De Wildt ,  Claire Holland ,  Alan Peter Lewis ,  Peter Morley ,  Thomas Sandal ,  Michael Steward

IPC分类号： C07K16/00 ,  A61K39/395 ,  C07K16/42 ,  C07K16/28 ,  C07K16/22

摘要： The present disclosure relates to modified proteins and peptides that have reduced ability to bind to pre-existing antibodies. Such modified protein/peptide molecules can comprise C-terminal additions, extensions or tags and/or certain amino acid substitutions. Such modified molecules (e.g., fusions and conjugates) comprise proteins, peptides, antigen binding molecules, antibodies or antibody fragments such as single variable domains. The disclosure further relates to uses and formulations of compositions comprising such modified C-terminally extended and/or amino acid substituted molecules and also to methods of production and expression of these.

公开(公告)号：US08933295B2

公开(公告)日：2015-01-13

申请号：US12993480

申请日：2009-06-03

申请人： Sun-Yung Jung ,  Mary Birchler

发明人： Sun-Yung Jung ,  Mary Birchler

IPC分类号： A01K67/027 ,  A01K1/03 ,  A01K67/02 ,  A61K49/00

CPC分类号： A01K1/031 ,  A01K67/02 ,  A61K49/0008

摘要： The method of the invention is useful for evaluating pharmaceutical compositions for treatment of neurological diseases encompassing neurological or neurodegenerative diseases associated with cognitive dysfunction and, in particular, dementia; schizophrenia; anxiety; depression; and pain using a rodent behavioral assay, wherein the method is useful in testing compositions useful in the modulation, amelioration, prevention, or treatment of dementia using a non-human animal carrying at least a transgene for human amyloid-beta protein or human tau and transgenes causing the elevated production of the human amyloid-beta protein in the animal as compared to nontransgenic animals of the same genetic background and the behavior is a nesting behavior.

摘要翻译： 本发明的方法可用于评估用于治疗包括与认知功能障碍相关的神经或神经变性疾病，特别是痴呆的神经疾病的药物组合物; 精神分裂症 焦虑; 萧条; 和使用啮齿动物行为测定法的疼痛，其中所述方法可用于测试使用至少携带人淀粉样蛋白-β蛋白或人tau的转基因的非人动物进行调节，改善，预防或治疗痴呆的组合物，以及 与相同遗传背景的非转基因动物相比，导致动物中人淀粉样蛋白-β蛋白产生升高的转基因是嵌套行为。