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    Liver X receptor agonists
    3.
    发明授权
    Liver X receptor agonists 失效
    肝X受体激动剂

    公开(公告)号：US07012069B2

    公开(公告)日：2006-03-14

    申请号：US10137695

    申请日：2002-05-02

    Applicant: Ching Song ,  Shutsung Liao

    Inventor： Ching Song ,  Shutsung Liao

    IPC: A61K31/56 ,  C07J9/00

    CPC classification number: C07J9/00 ,  C07J1/00 ,  C07J31/00 ,  C07J41/00

    Abstract: A compound of formula (I): Each of R1, R2, R3, R4, R4′, R5, R6, R7, R11, R12, R15, R16, and R17, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxy, amino, carboxyl, oxo, sulfonic acid, or alkyl that is optionally inserted with —NH—, —N(alkyl)—, —O—, —S—, —SO—, —SO2—, —O—SO2—, —SO2—O—, —SO3—O—, —CO—, —CO—O—, —O—CO—, —CO—NR′—, or —NR′—CO—; or R3 and R4 together, R4 and R5 together, R5 and R6 together, or R6 and R7 together are eliminated so that a C═C bond is formed between the carbons to which they are attached; each of R8, R9, R10, R13, and R14, independently, is hydrogen, halo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, hydroxy, or amino; n is 0, 1, or 2; A is alkylene, alkenylene, or alkynylene; and each of X, Y, and Z, independently, is alkyl, haloalkyl, —OR′, —SR′, —NR′R″, —N(OR′)R″, or —N(SR′)R″; or X and Y together are ═O, ═S, or ═NR′; wherein each of R′ and R″, independently, is hydrogen, alkyl, or haloalkyl.

    Abstract translation: 式（I）的化合物：R 1，R 2，R 3，R 4， R 4'，R 5，R 6，R 7，R 11， R 12，R 15，R 16和R 17独立地是氢，卤素，烷基 ，卤代烷基，羟基，氨基，羧基，氧代，磺酸或任选地被-NH-， - N（烷基） - ， - O - ， - S - ， - SO - ， - SO 2 -O - SO 2 - ， - SO 2 -O - ， - SO 3 -O - ， - CO - ，-CO-O-，-O-CO-，-CO-NR'-或-NR'-CO-; 或R 3和R 4一起为R 4和R 5一起为R 5， SUB>和R 6一起，或R 6和R 7一起被除去，使得在它们之间的碳之间形成CC键 附上 R 8，R 9，R 10，R 13和R 14中的每一个， 独立地是氢，卤素，烷基，卤代烷基，羟烷基，烷氧基，羟基或氨基; n为0,1或2; A是亚烷基，亚烯基或亚炔基; 并且X，Y和Z各自独立地是烷基，卤代烷基，-OR'，-SR'，-NR'R“， - N（OR'）R”或-N（SR'）R “” 或X和Y一起为-O，-S或-NR'; 其中R'和R“各自独立地是氢，烷基或卤代烷基。

    Method Of Treating Disorder Related To High Cholesterol Concentration
    6.
    发明申请
    Method Of Treating Disorder Related To High Cholesterol Concentration 审中-公开
    治疗高胆固醇浓度相关疾病的方法

    公开(公告)号：US20110160174A1

    公开(公告)日：2011-06-30

    申请号：US13046074

    申请日：2011-03-11

    Applicant: Ching Song ,  Shutsung Liao ,  Qing Dai

    Inventor： Ching Song ,  Shutsung Liao ,  Qing Dai

    IPC: A61K31/575 ,  A61P3/06 ,  A61P9/00 ,  A61P25/28

    CPC classification number: C07J41/0061 ,  A61K31/56 ,  A61K31/575 ,  C07J9/00 ,  C07J41/00

    Abstract: A method of treating a disorder related to a high cholesterol concentration, comprising administering to a subject in need thereof a compound of formula (I): Also disclosed are methods, kits, combinations, and compositions for treating a disorder in a subject where an activator of liver X alpha is indicated, such as in, for example, treating a high cholesterol disease.

    Abstract translation: 一种治疗与高胆固醇浓度相关的病症的方法，包括向有需要的受试者施用式（I）化合物：还公开了用于治疗受试者中的病症的方法，试剂盒，组合和组合物，其中活化剂 指示肝Xα，例如在例如治疗高胆固醇疾病中。

    Liver X receptor agonists
    10.
    发明授权
    Liver X receptor agonists 有权
    肝X受体激动剂

    公开(公告)号：US08829213B2

    公开(公告)日：2014-09-09

    申请号：US12846326

    申请日：2010-07-29

    Applicant: Dacheng Peng ,  John Kokontis ,  Richard Hiipakka ,  Shutsung Liao

    Inventor： Dacheng Peng ,  John Kokontis ,  Richard Hiipakka ,  Shutsung Liao

    IPC: C07J9/00

    CPC classification number: C07J9/00 ,  C07J9/005

    Abstract: Compounds of formula (I): in which R1, R2, R3, R3′, R4, R5, R6, R6′, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, A, D, X, Y, and Z are defined in the specification. Also disclosed is a method of using one of the compounds to lower the blood cholesterol level and treat cancer, atherosclerosis, diabetes, Alzheimer's disease, and corneal arcus.

    Abstract translation: 式（I）化合物：其中R1，R2，R3，R3'，R4，R5，R6，R6'，R7，R8，R9，R10，R11，R12，R13，R14，R15，R16，R17， 在说明书中定义了D，X，Y和Z。 还公开了使用一种化合物降低血液胆固醇水平并治疗癌症，动脉粥样硬化，糖尿病，阿尔茨海默病和角膜弧的方法。

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