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    Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof
    1.
    发明授权
    Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof 有权
    表面增强拉曼光谱（SERS）活性复合纳米颗粒，其制造方法及其使用方法

    公开(公告)号：US07588827B2

    公开(公告)日：2009-09-15

    申请号：US10919944

    申请日：2004-08-17

    申请人： Shuming Nie ,  William Doering

    发明人： Shuming Nie ,  William Doering

    IPC分类号： B32B5/66

    CPC分类号： G01N21/658 ,  B82Y10/00 ,  B82Y30/00 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

    摘要： Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface-enhanced Raman spectroscopic active composite nanostructure. The surface-enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof. The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.

    摘要翻译： 公开了纳米颗粒，其制备方法和使用纳米颗粒的实施方案检测靶分子的方法。 示例性纳米颗粒的一个实施方案包括表面增强拉曼光谱活性复合纳米结构。 表面增强拉曼光谱活性复合纳米结构包括芯，至少一个报道分子和封装材料。 报道分子与芯结合。 报告分子选自：异硫氰酸酯染料，多硫有机染料，多异硫有机染料，苯并三唑染料及其组合。 封装材料设置在核心和报告分子之上。 封装材料封装后，报告分子具有可测量的表面增强拉曼光谱特征。

    Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof
    2.
    发明申请
    Surface enhanced Raman spectroscopy (SERS)-active composite nanoparticles, methods of fabrication thereof, and methods of use thereof 有权
    表面增强拉曼光谱（SERS）活性复合纳米颗粒，其制造方法及其使用方法

    公开(公告)号：US20090140206A1

    公开(公告)日：2009-06-04

    申请号：US10919944

    申请日：2004-08-17

    申请人： Shuming Nie ,  William Doering

    发明人： Shuming Nie ,  William Doering

    IPC分类号： G01J3/44 ,  B23B5/02 ,  B05D7/00 ,  C09K11/06

    CPC分类号： G01N21/658 ,  B82Y10/00 ,  B82Y30/00 ,  Y10T428/2991 ,  Y10T428/2993 ,  Y10T428/2995 ,  Y10T428/2996 ,  Y10T428/2998

    摘要： Nanoparticles, methods of preparation thereof, and methods of detecting a target molecule using embodiments of the nanoparticle, are disclosed. One embodiment of an exemplary nanoparticle, among others, includes a surface-enhanced Raman spectroscopic active composite nanostructure. The surface-enhanced Raman spectroscopic active composite nanostructure includes a core, at least one reporter molecule, and an encapsulating material. The reporter molecule is bonded to the core. The reporter molecule is selected from: an isothiocyanate dye, a multi-sulfur organic dye, a multi-heterosulfur organic dye, a benzotriazole dye, and combinations thereof The encapsulating material is disposed over the core and the reporter molecule. After encapsulation with the encapsulating material, the reporter molecule has a measurable surface-enhanced Raman spectroscopic signature.

    摘要翻译： 公开了纳米颗粒，其制备方法和使用纳米颗粒的实施方案检测靶分子的方法。 示例性纳米颗粒的一个实施方案包括表面增强拉曼光谱活性复合纳米结构。 表面增强拉曼光谱活性复合纳米结构包括芯，至少一个报道分子和封装材料。 报道分子与芯结合。 报告分子选自：异硫氰酸酯染料，多硫有机染料，多异硫有机染料，苯并三唑染料及其组合。封装材料设置在核心和报道分子上。 封装材料封装后，报告分子具有可测量的表面增强拉曼光谱特征。

    COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF
    5.
    发明申请
    COATED QUANTUM DOTS AND METHODS OF MAKING AND USING THEREOF 审中-公开
    涂层量子及其制备方法和使用方法

    公开(公告)号：US20110189102A1

    公开(公告)日：2011-08-04

    申请号：US12864763

    申请日：2009-02-05

    申请人： Brad A. Kairdolf ,  Shuming Nie

    发明人： Brad A. Kairdolf ,  Shuming Nie

    IPC分类号： H01L33/06 ,  A61B5/00 ,  H01L33/52 ,  B82Y99/00 ,  B82Y40/00 ,  B82Y20/00

    CPC分类号： G01N21/6486 ,  B82Y30/00

    摘要： The present disclosure provides embodiments of a new class of hydroxylated quantum dots. The quantum dots have a hydroxylated coat disposed thereon, and which serves to minimize non-specific cellular binding and to maintain the small size of quantum dot probes. Embodiments of the coated quantum dots of the disclosure are just slightly larger than the diameter of uncoated quantum dots, and are bright with high quantum yields. They are also very stable under both basic and acidic conditions. Embodiments of the hydroxylated quantum dots result in significant reductions in non-specific binding relative to that of carboxylated dots, and to protein and PEG-coated dots. Embodiments of the disclosure are advantageous in a range of biological applications where non-specific binding is a major problem, such as in multiplexed biomarker staining in cells and tissues, detection of biomarkers in body fluid samples (blood, urine, etc.), as well as live cell imaging.

    摘要翻译： 本公开提供了一类新型羟基化量子点的实施方案。 量子点具有设置在其上的羟基化涂层，其用于最小化非特异性细胞结合并维持量子点探针的小尺寸。 本公开的涂覆的量子点的实施例略大于未涂覆的量子点的直径，并且具有高量子产率的明亮。 它们在碱性和酸性条件下也非常稳定。 羟基化量子点的实施方案导致非特异性结合相对于羧化点，以及蛋白质和PEG-包被点的显着降低。 本公开的实施方案在生物应用范围内是有利的，其中非特异性结合是主要问题，例如细胞和组织中多重生物标志物染色，体液样品（血液，尿液等）中生物标志物的检测，如 以及活细胞成像。

    SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE
    6.
    发明申请
    SYSTEM AND METHODS FOR PROVIDING REAL-TIME ANATOMICAL GUIDANCE IN A DIAGNOSTIC OR THERAPEUTIC PROCEDURE 审中-公开
    用于在诊断或治疗过程中提供实时解剖学指导的系统和方法

    公开(公告)号：US20110152692A1

    公开(公告)日：2011-06-23

    申请号：US12969396

    申请日：2010-12-15

    申请人： Shuming Nie ,  Aaron Mohs ,  Michael Mancini

    发明人： Shuming Nie ,  Aaron Mohs ,  Michael Mancini

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0035 ,  A61B5/0071 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/0086 ,  A61B5/06 ,  A61B5/415 ,  A61B5/418 ,  A61B5/7425 ,  A61B90/361 ,  A61B90/37 ,  A61B2090/365 ,  A61K49/0017

    摘要： According to one aspect, a system for intraoperatively providing anatomical guidance in a diagnostic or therapeutic procedure is disclosed. In one embodiment, the system includes: a first light source configured to emit a beam of visible light; second light source configured to emit a beam of near-infrared light; a handheld probe optically coupled to the second light source; a second imaging device configured to detect visible light; a third imaging device configured to detect near-infrared light having a first predetermined wavelength; a fourth imaging device configured to detect near-infrared light having a second predetermined wavelength; a display for displaying at least one visual representation of data; and, a controller programmed to generate at least one real-time integrated visual representation of an area of interest and to display the real-time visual representation on the display for guidance during the diagnostic or therapeutic procedure.

    摘要翻译： 根据一个方面，公开了一种用于在诊断或治疗过程中在手术中提供解剖指导的系统。 在一个实施例中，该系统包括：被配置为发射可见光束的第一光源; 第二光源，被配置为发射近红外光束; 光学耦合到第二光源的手持式探针; 被配置为检测可见光的第二成像装置; 第三成像装置，被配置为检测具有第一预定波长的近红外光; 第四成像装置，被配置为检测具有第二预定波长的近红外光; 用于显示数据的至少一个视觉表示的显示器; 以及控制器，被编程为生成感兴趣区域的至少一个实时集成视觉表示，并且在诊断或治疗过程期间在显示器上显示实时视觉表示以进行指导。

    Branched Multifunctional Nanoparticle Conjugates And Their Use
    7.
    发明申请
    Branched Multifunctional Nanoparticle Conjugates And Their Use 审中-公开
    分支多功能纳米粒子共轭体及其用途

    公开(公告)号：US20110060036A1

    公开(公告)日：2011-03-10

    申请号：US12888767

    申请日：2010-09-23

    申请人： Shuming Nie ,  Hongwei Duan ,  Min Kuang

    发明人： Shuming Nie ,  Hongwei Duan ,  Min Kuang

    IPC分类号： A61K31/337 ,  C07D305/14 ,  A61P35/00 ,  B82Y5/00

    CPC分类号： C08G83/006 ,  A61K47/56 ,  A61K47/6939 ,  B82Y5/00 ,  C08G83/005

    摘要： Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are useful for the targeted delivery of antitumor agents and imaging agents to tumors in vivo. Methods are also disclosed for detecting and treating such tumors.

    摘要翻译： 本文公开了包含聚甘油纳米载体，治疗剂或成像剂以及任选的靶向剂的化合物和组合物。 在某些方面，所公开的化合物包括生物相容性超支化聚合物纳米载体。 这样的化合物和组合物可用于体内向肿瘤靶向递送抗肿瘤剂和成像剂。 还公开了用于检测和治疗这些肿瘤的方法。