公开(公告)号：US20110060036A1

公开(公告)日：2011-03-10

申请号：US12888767

申请日：2010-09-23

Applicant: Shuming Nie ,  Hongwei Duan ,  Min Kuang

Inventor： Shuming Nie ,  Hongwei Duan ,  Min Kuang

IPC: A61K31/337 ,  C07D305/14 ,  A61P35/00 ,  B82Y5/00

CPC classification number: C08G83/006 ,  A61K47/56 ,  A61K47/6939 ,  B82Y5/00 ,  C08G83/005

Abstract: Disclosed herein are compounds and compositions including a polyglycerol nanocarrier, a therapeutic agent or imaging agent, and optionally a targeting agent. In certain aspects the disclosed compounds include biocompatible hyperbranched polymer nanocarriers. Such compounds and compositions are useful for the targeted delivery of antitumor agents and imaging agents to tumors in vivo. Methods are also disclosed for detecting and treating such tumors.

Abstract translation: 本文公开了包含聚甘油纳米载体，治疗剂或成像剂以及任选的靶向剂的化合物和组合物。 在某些方面，所公开的化合物包括生物相容性超支化聚合物纳米载体。 这样的化合物和组合物可用于体内向肿瘤靶向递送抗肿瘤剂和成像剂。 还公开了用于检测和治疗这些肿瘤的方法。