Purified mite allergen
    1.
    发明授权
    Purified mite allergen 失效
    净化螨过敏原

    公开(公告)号:US5747047A

    公开(公告)日:1998-05-05

    申请号:US293605

    申请日:1994-08-22

    CPC分类号: C07K14/43531 A61K38/00

    摘要: The present invention is directed to novel purified and isolated mite allergens possessing mite allergen activity with a molecular weight of about 94,000, about 40,000, about 16,000 or about 14,000 as determined by SDS-PAGE, which can be isolated from extracts of mite, and to a process for producing such mite allergens. The purified and isolated mites allergens of the present invention are useful as a pharmaceutical and a diagnostic composition for mite allergic diseases.

    摘要翻译: 本发明涉及具有螨过敏原活性的新型纯化和分离的螨变应原,其分子量约为94,000,约40,000,约16,000或约14,000,通过SDS-PAGE测定,其可以从螨的提取物中分离,并且 一种生产这种螨变应原的方法。 本发明的纯化和分离的螨过敏原可用作螨过敏性疾病的药物和诊断组合物。

    Purified mite allergen
    2.
    发明授权
    Purified mite allergen 失效
    净化螨过敏原

    公开(公告)号:US6054125A

    公开(公告)日:2000-04-25

    申请号:US9835

    申请日:1998-01-20

    CPC分类号: C07K14/43531 A61K38/00

    摘要: The present invention is directed to novel purified and isolated mite allergens possessing mite allergen activity with a molecular weight of about 94,000, about 40,000, about 16,000 or about 14,000 as determined by SDS-PAGE, which can be isolated from extracts of mites, and to a process for producing such mites allergens. The purified and isolated mite allergens of the present invention are useful as a pharmaceutical and a diagnostic composition for mite allergic diseases.

    摘要翻译: 本发明涉及具有螨过敏原活性的新型纯化和分离的螨变应原,其分子量约为94,000,约40,000,约16,000或约14,000,通过SDS-PAGE测定,其可以从螨的提取物中分离,并且 一种生产这种螨变应原的方法。 本发明的纯化和分离的螨过敏原可用作螨过敏性疾病的药物和诊断组合物。

    Low molecular weight allergen obtained from Dermatophagoides farinae
    5.
    发明授权
    Low molecular weight allergen obtained from Dermatophagoides farinae 失效
    从Dermatophagoides farinae获得的低分子量过敏原

    公开(公告)号:US5773010A

    公开(公告)日:1998-06-30

    申请号:US564395

    申请日:1995-11-29

    CPC分类号: C07K14/43531 A61K38/00

    摘要: New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen has a weight average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium. This is a glycoprotein containing more than about 70% sugar, and possesses allergen activity. The low molecular weight antigen has a molecular weight of 1,500 to 5,000 as determined by Sephadex G25 gel filtration. This is a glycoprotein containing more than about 40% sugar, and also possesses allergen activity.

    摘要翻译: 提供了用作治疗和诊断螨过敏性疾病的药物和诊断组合物的新的纯化螨过敏原。 两种过敏原都包含在文化中螨的粪便提取物中。 高分子量变应原具有通过沉降平衡测定的重均分子量为70,000至80,000。 这是含有超过约70%糖的糖蛋白,具有过敏原活性。 通过Sephadex G25凝胶过滤测定,低分子量抗原的分子量为1,500至5,000。 这是一种含有超过约40%糖的糖蛋白,也具有过敏原活性。

    Purified mite allergen
    6.
    发明授权
    Purified mite allergen 失效
    净化螨过敏原

    公开(公告)号:US5496554A

    公开(公告)日:1996-03-05

    申请号:US283905

    申请日:1994-08-04

    CPC分类号: C07K14/43531 A61K38/00

    摘要: New purified mite allergens useful as pharmaceutical and diagnostic compositions for the treatment and diagnosis of mite allergic diseases are provided. Both allergens are contained in fecal extracts of mites in culture. The high molecular weight allergen has a weight average molecular weight of 70,000 to 80,000 as determined by sedimentation equilibrium. This is a glycoprotein containing more than about 70% sugar, and possesses allergen activity. The low molecular weight antigen has a molecular weight of 1,500 to 5,000 as determined by Sephadex G25 gel filtration. This is a glycoprotein containing more than about 40% sugar, and also possesses allergen activity.

    摘要翻译: 提供了用作治疗和诊断螨过敏性疾病的药物和诊断组合物的新的纯化螨过敏原。 两种过敏原都包含在文化中螨的粪便提取物中。 高分子量变应原具有通过沉降平衡测定的重均分子量为70,000至80,000。 这是含有超过约70%糖的糖蛋白,具有过敏原活性。 通过Sephadex G25凝胶过滤测定,低分子量抗原的分子量为1,500至5,000。 这是一种含有超过约40%糖的糖蛋白,也具有过敏原活性。