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公开(公告)号：US20230417704A1
公开(公告)日：2023-12-28
申请号：US18367003
申请日：2023-09-12
申请人： Shimadzu Corporation
发明人： Xiaoqiang ZHANG , Keke WANG , Wenjian SUN
IPC分类号： G01N27/623
CPC分类号： G01N27/623
摘要： A high duty cycle ion mobility analysis apparatus includes an ion source, first and second ion storage zones, and an ion mobility analyzer. The ion mobility analyzer includes first and second channels containing a gas flow paralleled to an ion migration direction and a direct current electric field in the opposite direction of the gas flow, and the direct current electric fields in the channels are different in strength. In a continuous scanning period, ions that have not reached appropriate scanning conditions or have missed the appropriate scanning conditions and thus are unable to pass through the mobility analyzer are temporarily stored in two independent ion storage zones without being lost to be analyzed by the mobility analyzer until conditions of the scanning period or a next scanning period are appropriate.
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2.发明申请公开(公告)号：US20180174813A1
公开(公告)日：2018-06-21
申请号：US15736138
申请日：2016-06-20
申请人： SHIMADZU CORPORATION
发明人： Xiaoqiang ZHANG , Gongyu JIANG , Yunqing HUANG , Jiaqi SHEN , Wenjian SUN
CPC分类号： H01J49/067 , H01J49/0404 , H01J49/10 , H01J49/24 , H01J49/26
摘要： The disclosure relates to a mass spectrometer and a method applied thereby for reducing ion loss and succeeding stage vacuum load. The mass spectrometer includes an ion source connected via vacuum interfaces, a vacuum chamber and a succeeding stage device; wherein a tubular lens is arranged above a Mach disc formed by a gas flow carrying ions at the vacuum interfaces, so that an ion transfer path is restrained and the ions scattering with the gas flow is reduced. In comparison to a sole reliance on a radio-frequency voltage for focusing ions, the efficiency of ion capture in a jet region is improved by using an aerodynamic lens; and the desolvation efficiency of electrically charged droplets is also improved, thereby further improving the sensitivity of the mass spectrometer. Meanwhile, the tubular aerodynamic lens is simple in structure and small in size.
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3.发明申请公开(公告)号：US20200273685A1
公开(公告)日：2020-08-27
申请号：US16684752
申请日：2019-11-15
申请人： SHIMADZU CORPORATION
发明人： Liang WANG , Wenjian SUN , Xiaoqiang ZHANG
摘要： The invention relates to an ion source for generating ions for calibrating a mass spectrometer and methods for calibrating the mass spectrometer using the generated ions. The ion source includes a container used for containing a sample; an ionization device used for ionizing a sample by plasma discharge to generate ions for calibrating the mass spectrometer, where the ionization device operates at atmospheric pressure; and a delivery device for delivering the sample from the container to the ionization device. The method includes generating ions by plasma discharge at atmospheric pressure using a sample; inputting at least one part of the ions into the mass spectrometer to obtain a mass spectrogram; and calibrating the mass spectrometer according to the mass spectrogram.
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公开(公告)号：US20170236698A1
公开(公告)日：2017-08-17
申请号：US15503523
申请日：2015-09-02
申请人： SHIMADZU CORPORATION
发明人： Xiaoqiang ZHANG , Qiao JIN , Wenjian SUN
CPC分类号： H01J49/062 , G01N27/622 , H01J49/42
摘要： An ion optical apparatus and a mass spectrometer are provided. The ion optical apparatus includes at least one planar insulating substrate which is covered with metal patterns to form an electrode array including a plurality of cell electrodes, wherein each of the cell electrodes is arrayed according to a first direction to form a geometric pattern distribution of the electrode array, wherein cell electrodes are applied with radio frequency (RF) voltages having different phases to confine ions, a direct current (DC) voltage gradient is applied along at least part of the cell electrodes in the electrode array to drive ions to move in the first direction along the electrode array, and a corresponding electric field distribution is formed by the geometric pattern distribution to drive ions to move in a second direction substantially orthogonal to the first direction, thereby realizing ion deflection, focusing or defocusing.
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公开(公告)号：US20210313161A1
公开(公告)日：2021-10-07
申请号：US17216988
申请日：2021-03-30
申请人： Shimadzu Corporation
发明人： Wenjian SUN , Ran QIU , Xiaoqiang ZHANG
摘要： The invention provides a mass spectrometry analysis method and a mass spectrometry system, including: a first sample separation step, separating a sample by a first sample separation device to obtain first isolates; a second sample separation step, introducing ionized first isolates into a second sample separation device for further separation based on a difference in ion mobility to obtain second isolates; and a mass spectrometry analysis step, performing mass spectrometry detection at least on daughter ions obtained from dissociation of the second isolates; in the second sample separation step, the second sample separation device operates in a filter mode, and screens out and releases ions having ion mobility within a specified range from received second isolates. The mass spectrometry analysis method can improve the dynamic range of mass spectrometry analysis.
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公开(公告)号：US20200278330A1
公开(公告)日：2020-09-03
申请号：US16645902
申请日：2018-11-14
申请人： SHIMADZU CORPORATION
发明人： Yunqing HUANG , Wenjian SUN , Xiaoqiang ZHANG
摘要： A data acquisition and analysis method for a mass spectrometer includes providing at least one ion source for generating ions, the generated ions containing ions of a substance to be analyzed; dividing the full mass-to-charge ratio range of the ions of the substance into several mass-to-charge ratio windows, feeding ions corresponding to different mass-to-charge ratio windows into a collision cell to fragment at least part of the corresponding ions, and recording mass spectra of the ions passing through the collision cell as corresponding product ion spectra; obtaining a mass-to-charge ratio window corresponding to the product ion spectra obtained by the searching; within the mass-to-charge ratio range of the obtained mass-to-charge ratio window, obtaining ion peaks from the product ion spectra obtained by the searching; and determining whether ions corresponding to the obtained ion peaks are precursor ions corresponding to the product ion spectra obtained by the searching.
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7.发明申请公开(公告)号：US20190172694A1
公开(公告)日：2019-06-06
申请号：US16095747
申请日：2017-06-12
申请人： SHIMADZU CORPORATION
发明人： Jiaqi SHEN , Wenjian SUN , Xiaoqiang ZHANG
CPC分类号： H01J49/0036 , H01J49/40
摘要： The invention provides signal processing method and system and an electronic apparatus for analysis of time-of-flight mass spectra. The method includes digitalizing an analog signal output from an ion detector to acquire complete raw time-of-flight spectra or each effective part in the raw time-of-flight spectra for a plurality of times; if the complete raw time-of-flight spectra are acquired, extracting the effective parts of each raw time-of-flight spectrum; applying a one-dimensional wavelet transform to each effective part to map to each frequency band or scale; determining positions and intensities of each spectral peak in each raw time-of-flight spectrum by detecting the maxima of an obtained wavelet coefficient distribution, and saving said peak position and intensity as characteristic data of each spectral peak; accumulating the characteristic data obtained by processing each raw time-of-flight spectrum and stacking the data to form spectral peak intensity/time-of-flight histogram.
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公开(公告)号：US20190056351A1
公开(公告)日：2019-02-21
申请号：US15760445
申请日：2016-12-13
申请人： SHIMADZU CORPORATION
发明人： Xiaoqiang ZHANG , Wenjian SUN
CPC分类号： G01N27/622 , H01J49/063 , H01J49/40
摘要： An ion mobility spectrometry apparatus and method are provided. The ion mobility spectrometry apparatus includes an ion source for providing ions; an ion guiding device having: at least three ends internally communicated: first, second and third guiding ends, wherein ions can enter or exit from the ion guiding device from any ends thereof, the first guiding end is used for entrance of ions provided by the ion source, and the third guiding end is communicated with a downstream device; at least one drift cell in correspondence to the second guiding end, for transmitting ions and/or performing ion mobility analysis, each drift cell having a first and second ends which are internally communicated, wherein the second end of drift cell is communicated with said second guiding end; an ion storage device communicated with said first end of the drift cell, for storing ions or ejecting ions.
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公开(公告)号：US20180174812A1
公开(公告)日：2018-06-21
申请号：US15736107
申请日：2016-06-20
申请人： SHIMADZU CORPORATION
发明人： Yupeng CHENG , Xiaoqiang ZHANG , Wenjian SUN
CPC分类号： H01J49/066 , G01N27/622 , H01J49/40 , H01J49/4205
摘要： The disclosure relates to an ion guiding device, including which comprises two sets of electrodes extending along a certain space axis, a first power supply device and a second power supply device. The electrodes are expandably arranged along a direction perpendicular to the space axis, at least one surface of each electrode in each set of electrodes is substantially on the same space plane, and the space planes for each set of electrodes are not same and not parallel, thereby forming an ion transmission channel having the cross sectional area gradually reduced in a direction perpendicular to the space axis; the first power supply device is used for applying radio-frequency voltages on at least a part of electrodes in the two sets of electrodes; and the second power supply device is used for applying voltage signals on at least a part of electrodes in the two sets of electrodes.
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公开(公告)号：US20240213011A1
公开(公告)日：2024-06-27
申请号：US18508669
申请日：2023-11-14
申请人： SHIMADZU CORPORATION
发明人： Xiaoqiang ZHANG , Zhi Geng , Wenjian Sun
CPC分类号： H01J49/063 , H01J49/24
摘要： The technical solution of the present disclosure provides an ion source apparatus and a mass spectrometer. According to the ion source apparatus, the axial ion guide assembly includes the plurality of multipole segments extending axially, the transmission path of axial ions is straight, and the ion transmission efficiency is substantially unaffected when the axial ion source is used alone. Further, since the ion outlet of the lateral ion guide assembly faces a gap between two adjacent segmented multipoles, the lateral ion guide assembly does not affect axial field, thereby integrating the multiple ion sources while ensuring the ion transmission efficiency and ion constraining of the axial ion source.
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