公开(公告)号：US20230417704A1

公开(公告)日：2023-12-28

申请号：US18367003

申请日：2023-09-12

Applicant: Shimadzu Corporation

Inventor： Xiaoqiang ZHANG ,  Keke WANG ,  Wenjian SUN

IPC: G01N27/623

CPC classification number: G01N27/623

Abstract: A high duty cycle ion mobility analysis apparatus includes an ion source, first and second ion storage zones, and an ion mobility analyzer. The ion mobility analyzer includes first and second channels containing a gas flow paralleled to an ion migration direction and a direct current electric field in the opposite direction of the gas flow, and the direct current electric fields in the channels are different in strength. In a continuous scanning period, ions that have not reached appropriate scanning conditions or have missed the appropriate scanning conditions and thus are unable to pass through the mobility analyzer are temporarily stored in two independent ion storage zones without being lost to be analyzed by the mobility analyzer until conditions of the scanning period or a next scanning period are appropriate.

公开(公告)号：US20230046612A1

公开(公告)日：2023-02-16

申请号：US17882803

申请日：2022-08-08

Applicant: Shimadzu Corporation

Inventor： Wenjian SUN ,  Kuo-Feng TSENG ,  Keke WANG ,  Xiaoqiang ZHANG

IPC: G01N27/623 ,  H01J49/42

Abstract: An ion mobility spectrometry-mass spectrometry combined analysis device includes an ionization source producing target analyte ions; an ion mobility filter receiving at least a part of the target analyte ions from the ionization source and operating in a sub-atmospheric environment to select ions within a specified mobility range from the target analyte ions to pass; and a mass filter connected to the rear stage of the ion mobility filter selecting ions in a specified mass-to-charge ratio range from the ions within the specified mobility range to pass. The ion mobility spectrometry-mass spectrometry combined device can separate the target ions based on a collision cross section under the combined action of a scanning electric field and an external gas flow, and operate at low gas pressure, which improves the efficiency of target analysis and an intra-spectrum dynamic range, and perform highly reliable and accurate quantitative analysis on specific target ions.

公开(公告)号：US20220102128A1

公开(公告)日：2022-03-31

申请号：US17393507

申请日：2021-08-04

Applicant: Shimadzu Corporation

Inventor： Keke WANG ,  Xiaoqiang ZHANG ,  Wenjian SUN

IPC: H01J49/06 ,  H01J49/02

Abstract: An ion guide device includes a plurality of ring electrodes disposed in parallel, wherein each ring electrode includes at least 4 electrode units separated from each other, a channel for ion transmission is formed inside the plurality of ring electrodes, and an arrangement direction of the plurality of ring electrodes defines an axial direction of ion transmission; an radio-frequency voltage source, for applying out-of-phase radio-frequency voltages on the neighboring electrode units belonging to the same ring electrode, and applying in-phase radio frequency voltages on a neighboring electrode units along the axial direction, thereby forming an radio-frequency multipole field that confine ions in the ion guide device; and a direct-current voltage source, wherein the ions are transmitted off-axis and focused to a position closer to an inner surface of the ring electrode under a combined action of the radio-frequency voltage and the direct-current voltage.