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公开(公告)号：US12029601B2
公开(公告)日：2024-07-09
申请号：US17571889
申请日：2022-01-10
发明人： Peiyan Cao , Yurun Liu
CPC分类号： A61B6/50 , A61B6/4266 , A61B6/485 , G01N33/5091
摘要： Disclosed herein is a method, comprising: introducing a tracer into a body region of an organism at an introduction site of the organism; causing emission of characteristic X-rays of the tracer in the body region; capturing images of the tracer in the body region with the characteristic X-rays; determining a first three-dimensional (3D) distribution of the tracer in the body region based on the images; and examining the first 3D distribution of the tracer in the body region to identify a sentinel lymph node for the introduction site. If the sentinel lymph node is not identified in the first 3D distribution, the method further comprises repeating said causing, said capturing, and said determining thereby resulting in a second 3D distribution of the tracer in the body region; and examining the second 3D distribution to identify the sentinel lymph node.
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公开(公告)号：US11946884B2
公开(公告)日：2024-04-02
申请号：US17571909
申请日：2022-01-10
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01N23/223 , G01N33/58
CPC分类号： G01N23/223 , G01N33/582 , G01N2223/076 , G01N2223/612 , G01N2223/637
摘要： Disclosed herein is a method comprising: causing emission of characteristic X-rays of a first element attached to a first biological analyte; causing emission of characteristic X-rays of a second element attached to a second biological analyte; detecting a characteristic of the first biological analyte based on the characteristic X-rays of the first element and a characteristic of the second biological analyte based on the characteristic X-rays of the second element; wherein the first element and the second element are different; wherein the first biological analyte and the second biological analyte are in the same solution.
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3.发明授权公开(公告)号：US11944483B2
公开(公告)日：2024-04-02
申请号：US17178851
申请日：2021-02-18
发明人： Peiyan Cao , Yurun Liu
IPC分类号： A61B6/00 , A61B6/42 , G01N23/046 , G01T1/02 , G01T1/24
CPC分类号： A61B6/542 , A61B6/4233 , G01N23/046 , G01T1/026 , G01T1/247 , G01N2223/419 , G01N2223/501
摘要： Disclosed herein is a method comprising: determining doses of radiation received by a first set of pixels of a radiation detector; determining that the doses satisfy a criterion; adjusting exposure of the radiation detector to the radiation in response to the doses satisfying the criterion; and forming an image based on radiation received by a second set of pixels of the radiation detector.
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公开(公告)号：US11906676B2
公开(公告)日：2024-02-20
申请号：US17471715
申请日：2021-09-10
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , G01T1/2002
摘要： Disclosed herein is a radiation detector, comprising a first pixel; a first reflector; and a first scintillator, wherein the first reflector is configured to guide essentially all photons emitted by the first scintillator into the first pixel. The first reflector is configured to reflect photons emitted by the first scintillator toward the first reflector. The first scintillator is essentially completely enclosed by the first reflector and the first pixel.
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公开(公告)号：US11901244B2
公开(公告)日：2024-02-13
申请号：US17128952
申请日：2020-12-21
发明人： Peiyan Cao , Yurun Liu
IPC分类号： H01L21/66 , H01L27/146 , G01T1/24
CPC分类号： H01L22/22 , G01T1/24 , H01L27/14659 , H01L27/14661 , H01L27/14689 , H01L27/14696 , H01L27/14698
摘要： Disclosed herein is a method comprising: attaching a plurality of chips to a substrate, wherein each of the chips comprises only one pixel configured to detect radiation. Disclosed herein is a method comprising: attaching a wafer to a substrate, wherein the substrate comprises discrete electrodes, wherein the wafer comprises a radiation absorption layer and a plurality of electrical contacts, wherein each of the electrical contacts is connected to at least one of the discrete electrodes; identifying a defective area of the wafer; replacing a portion of the wafer with a chip configured to absorb radiation, the portion comprising the defective area.
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公开(公告)号：US11815633B2
公开(公告)日：2023-11-14
申请号：US17471670
申请日：2021-09-10
发明人： Yurun Liu , Peiyan Cao
CPC分类号： G01T1/24 , G01T1/2928
摘要： Disclosed herein are apparatuses for detecting radiation and methods of making them. The method comprises forming a recess into a semiconductor substrate, wherein a portion of the semiconductor substrate extends into the recess and is surrounded by the recess; depositing semiconductor nanocrystals into the recess, the semiconductor nanocrystals having a different composition from the semiconductor substrate; forming a first doped semiconductor region in the semiconductor substrate; forming a second doped semiconductor region in the semiconductor substrate; wherein the first doped semiconductor region and the second doped semiconductor region form a p-n junction that separates the portion from the rest of the semiconductor substrate.
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公开(公告)号：US11733407B2
公开(公告)日：2023-08-22
申请号：US17684787
申请日：2022-03-02
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01T1/24 , H01L27/146
CPC分类号： G01T1/247 , H01L27/1469 , H01L27/14659 , H01L27/14661 , H01L27/14689
摘要： Disclosed herein is a method for forming a radiation detector. The method comprises forming a radiation absorption layer and bonding an electronics layer to the radiation absorption layer. The electronics layer comprises an electronic system configured to process electrical signals generated in the radiation absorption layer upon absorbing radiation photons. The method for forming the radiation absorption layer comprises forming a trench into a first surface of a semiconductor substrate; doping a sidewall of the trench; forming a first electrical contact on the first surface; forming a second electrical contact on a second surface of the semiconductor substrate. The second surface is opposite the first surface. The method further comprises dicing the semiconductor substrate along the trench.
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公开(公告)号：US11644583B2
公开(公告)日：2023-05-09
申请号：US17307141
申请日：2021-05-04
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01T1/24 , H01L27/146 , A61B6/00 , G01N23/046 , G01V5/00 , H01J37/244
CPC分类号： G01T1/247 , H01L27/14623 , H01L27/14659 , H01L27/14676 , A61B6/4208 , G01N23/046 , G01V5/005 , H01J37/244
摘要： An apparatus, system and method suitable for detecting X-ray are disclosed. In one example, the apparatus comprises: an X-ray absorption layer and a mask; wherein the mask comprises a first window and a second window, and a portion between the first window and the second window; wherein the first and second windows are not opaque to an incident X-ray; wherein the portion is opaque to the incident X-ray; and wherein the first and second windows are arranged such that charge carriers generated in the X-ray absorption layer by an X-ray photon propagating through the first window and charge carriers generated in the X-ray absorption layer by an X-ray photon propagating through the second window do not spatially overlap.
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公开(公告)号：US11619754B2
公开(公告)日：2023-04-04
申请号：US17514154
申请日：2021-10-29
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01N23/04 , G01T1/24 , A61B6/14 , A61B6/00 , H01L27/146
摘要： Disclosed herein is a method comprising: forming a doped region of a semiconductor substrate by doping a surface of the semiconductor substrate with dopants; driving the dopants into the semiconductor substrate by annealing the semiconductor substrate; controlling doping profile of the doped region by repeating doping and annealing the semiconductor substrate; forming a first electrode on the semiconductor substrate, wherein the first electrode is in electrical contact with the doped region; forming an outer electrode arranged around the first electrode, wherein the outer electrode is electrically insulated from the first electrode.
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公开(公告)号：US11520064B2
公开(公告)日：2022-12-06
申请号：US17175906
申请日：2021-02-15
发明人： Peiyan Cao , Yurun Liu
IPC分类号： G01T1/24 , G01T1/29 , A61B6/00 , G01N23/083
摘要： An apparatus suitable for detecting X-ray is disclosed. In one example, the apparatus comprises an X-ray absorption layer and a controller. The X-ray absorption layer comprises a first pixel and a second pixel. The controller is configured for determining whether all carriers generated in the X-ray absorption layer by an X-ray photon are collected by the first pixel and the second pixel, and determining the energy of the X-ray photon based on a sum of a first portion of the carriers that is collected by the first pixel and a second portion of the carriers that is collected by the second pixel.
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