公开(公告)号：US11291774B2

公开(公告)日：2022-04-05

申请号：US14783552

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: a housing (20), a piston rod (120) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in a distal direction (1), a rotatable member (80) arranged on an axially extending axis of rotation (4) in the housing (20), said rotatable member (80) being rotatable in a dose incrementing direction (5) against the action of a spring element (78) and being operably engageable with the piston rod (120) during dose dispensing, a clutch member (150) comprising at least one radially displaceable clutch element (153) to engage with a rim (82) of the rotatable member (80) with variably adjustable strength.

公开(公告)号：US10099015B2

公开(公告)日：2018-10-16

申请号：US14783160

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/24

摘要： The present invention relates to a drive mechanism for a drug delivery device for dispensing of a dose of a medicament, and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in axial distal direction (1), —a drive sleeve (60) extending in axial direction (1, 2) and being rotatably supported in the housing (30), —a dose setting member (40) rotatably supported on a side wall portion (31) of the housing (30) and being rotatable with respect to an axis (41) extending in radial direction (r), —wherein the drive sleeve (60) is operably releasable from the piston rod (80) and rotatably engageable with the dose setting member (40) for setting of the dose.

公开(公告)号：US20160045663A1

公开(公告)日：2016-02-18

申请号：US14782622

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315

CPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/24 ,  A61M5/31511 ,  A61M5/31533 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31583 ,  A61M5/31593 ,  A61M2005/3126

摘要： The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) to operably engage with a piston (14) of a cartridge (12) for displacing the piston (14) in a distal direction (1), —a dose indicating member (40) with a dose size information (48) thereon, connected to a spring element (100) and being rotatable in a dose incrementing direction (5) against the action of the spring element (100) for setting of a dose, —a drive wheel (130) operably engaged with the piston rod (120) for displacing the piston rod (120) in distal direction (1) for dose dispensing, —wherein the dose indicating member (40) is engageable with the drive wheel (130) during dose dispensing to transfer a driving force to the drive wheel (130) when driven by the relaxing spring element (100) in a dose decrementing direction (6).

摘要翻译： 本发明涉及一种用于设置和分配药物剂量的药物输送装置的驱动机构，该机构包括：一个壳体（20），一个与活塞（14）可操作地接合的活塞杆（120） ），用于沿远侧方向（1）移动所述活塞（14）， - 连接到弹簧元件（100）上的剂量指示构件（40），其上具有剂量尺寸信息（48） 可旋转剂量递增方向（5），抵抗弹簧元件（100）用于设定剂量的作用， - 与活塞杆（120）可操作地接合的驱动轮（130），用于将活塞杆（120）移动到 用于剂量分配的远端方向（1），其中剂量指示构件（40）在剂量分配期间可与驱动轮（130）接合，以在由松弛弹簧元件驱动时将驱动力传递到驱动轮（130） 100）以剂量递减方向（6）。

公开(公告)号：US20220184316A1

公开(公告)日：2022-06-16

申请号：US17684115

申请日：2022-03-01

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315

摘要： The present invention relates to a drive mechanism of a drug delivery device for setting and dispensing of a dose of a medicament, the mechanism comprising: a housing (20), a piston rod (120) to operably engage with a piston (14) of a cartridge (12) to displace the piston (14) in a distal direction (1), a rotatable member (80) arranged on an axially extending axis of rotation (4) in the housing (20), said rotatable member (80) being rotatable in a dose incrementing direction (5) against the action of a spring element (78) and being operably engageable with the piston rod (120) during dose dispensing, a clutch member (150) comprising at least one radially displaceable clutch element (153) to engage with a rim (82) of the rotatable member (80) with variably adjustable strength.

公开(公告)号：US20160067414A1

公开(公告)日：2016-03-10

申请号：US14782655

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20

CPC分类号： A61M5/31541 ,  A61M5/20 ,  A61M5/31553 ,  A61M5/3157 ,  A61M5/31583 ,  A61M2005/3154 ,  A61M2205/581 ,  A61M2205/582

摘要： The present invention relates to a drive mechanism for a drug delivery device and to a respective drug delivery device, wherein the drive mechanism comprises: —an elongated housing (20) extending in an axial direction (1, 2), a piston rod (70) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in an axial distal direction (1), —a drive sleeve (50) rotatably supported in the housing (20) and being operably releasable from the piston rod (70) for setting of a dose and being operably engageable with the piston rod (70) for dispensing of the dose, —a dose limiting member (60) engaged with the drive sleeve (50) and engaged with the piston rod (70) in such a way, that it is displaced in axial direction (1, 2) relative to the drive sleeve (50) when the drive sleeve (50) rotates relative to the piston rod (70) during a dose setting procedure, and at least one stop (42, 56; 78) to engage with the dose limiting member (60) for limiting the axial displacement of the dose limiting member (60) during the dose setting procedure and to impede further displacement of the drive sleeve (50) relative to the piston rod (70).

摘要翻译： 本发明涉及一种用于药物输送装置和相应药物输送装置的驱动机构，其中驱动机构包括： - 沿轴向方向（1,2）延伸的细长壳体（20），活塞杆（70） 可操作地与柱塞14的活塞（16）接合以在轴向远端方向（1）移动活塞（16）， - 驱动套筒（50），可旋转地支撑在壳体（20）中并且可操作地 从所述活塞杆（70）可释放用于设定剂量并可与所述活塞杆（70）可操作地接合以分配所述剂量，所述剂量限制构件（60）与所述驱动套筒（50）接合并与所述活塞杆 活塞杆（70）以这种方式相对于驱动套筒（50）在剂量设定期间相对于活塞杆（70）旋转时相对于驱动套筒（50）在轴向方向（1,2）上移位 程序和至少一个止动件（42,56; 78）与剂量限制构件（60）接合，用于限制轴向位移 并且阻止驱动套筒（50）相对于活塞杆（70）的进一步移位。

公开(公告)号：US20160067412A1

公开(公告)日：2016-03-10

申请号：US14782706

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Michael Pfoser ,  Björn Wilden

IPC分类号： A61M5/315

CPC分类号： A61M5/3158 ,  A61M5/31541 ,  A61M5/31548 ,  A61M5/31553 ,  A61M5/31563 ,  A61M5/31568 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2205/581

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of dose of a medicament, the mechanism comprising: —an elongated housing (30) extending in an axial direction (1, 2), —a piston rod (80) to operably engage with a piston (16) of a cartridge (14) to displace the piston (16) in a distal axial direction (1), —a drive sleeve (50) extending in axial direction (1, 2) and being rotatable against the action of a spring (68) during a dose setting procedure, —a dispensing sleeve (70) rotatably engaged with the piston rod (80) and being displaceable in axial direction (1, 2) relative to the drive sleeve (50) to engage with the drive sleeve (50) in a torque transmissive way during a dose dispensing procedure.

摘要翻译： 本发明涉及用于分配药物剂量的药物输送装置的驱动机构，该机构包括： - 沿轴向方向（1,2）延伸的细长壳体（30）， - 活塞杆（80） 以与所述药筒（14）的活塞（16）可操作地接合以在远侧轴向方向（1）上移动所述活塞（16）， - 沿轴向方向（1,2）延伸的驱动套筒（50） 在剂量设定过程期间抵抗弹簧（68）的作用， - 分配套筒（70），其可旋转地与活塞杆（80）接合并且可相对于驱动套筒（50）沿轴向方向（1,2）移位， 在剂量分配过程期间以扭矩传递的方式与驱动套筒（50）接合。

公开(公告)号：US20160045673A1

公开(公告)日：2016-02-18

申请号：US14783190

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Bjorn Wilden ,  Wolfgang Pelzer

IPC分类号： A61M5/315 ,  A61M5/20

CPC分类号： A61M5/31553 ,  A61M5/2033 ,  A61M5/31541 ,  A61M5/31558 ,  A61M5/31563 ,  A61M5/3157 ,  A61M5/31575 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2086 ,  A61M2005/3126 ,  A61M2005/314 ,  A61M2005/3143 ,  A61M2005/31508 ,  A61M2005/3152 ,  A61M2005/3154 ,  A61M2205/581

摘要： The present invention relates to a drive mechanism of a drug delivery device for dispensing of a dose of a medicament, the mechanism comprising: —a housing (20), —a piston rod (120) extending in an axial direction (1, 2) to operably engage with a piston (14) of a cartridge (12), —a drive sleeve (90) rotatably supported in the housing (20), at least partially enclosing the piston rod (120), the drive sleeve (90) is operably releasable from the piston rod (120) for setting of a dose and the drive sleeve (90) is operably engageable with the piston rod (120) for dispensing of the dose, —a dose limiting member (130) threadedly engaged with the drive sleeve (90), rotatably locked to the housing (20) and being displaceable in axial direction (1, 2) in response to a rotation of the drive sleeve (90) relative to the piston rod (120), —at least one stop member (124) provided on the piston rod (120) to engage with the dose limiting member (130) for impeding a further displacement of the drive sleeve (90) relative to the piston rod (120), when a maximum dose configuration has been reached.

摘要翻译： 本发明涉及一种用于分配药物剂量的药物输送装置的驱动机构，该机构包括：一个壳体（20），一个沿轴向方向（1,2）延伸的活塞杆（120） 与所述盒（12）的活塞（14）可操作地接合， - 可旋转地支撑在所述壳体（20）中的至少部分地包围所述活塞杆（120）的驱动套筒（90），所述驱动套筒 可操作地从所述活塞杆（120）释放用于设定剂量，并且所述驱动套筒（90）可与所述活塞杆（120）可操作地接合，用于分配所述剂量，所述剂量限制构件（130）与所述驱动器螺纹接合 套筒（90），其可旋转地锁定到壳体（20）并响应于驱动套筒（90）相对于活塞杆（120）的旋转而沿轴向方向（1,2）移动， - 至少一个止动件 设置在活塞杆（120）上以与剂量限制构件（130）接合的构件（124），用于阻止进一步移动 当达到最大剂量配置时，驱动套筒（90）相对于活塞杆（120）。

公开(公告)号：US10124118B2

公开(公告)日：2018-11-13

申请号：US14782723

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A drive mechanism of a drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction, a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction, and a drive sleeve extending in the axial direction and being rotatable in a dose incrementing direction against the action of a spring enclosing at least an axial portion of the drive sleeve. The drive mechanism further includes a dose limiting member threadedly engaged with the drive sleeve, rotatably locked to the housing and at least partially extending radially between the drive sleeve and the spring, and at least one stop located on at least one of dose limiting member and drive sleeve for limiting an axial displacement of the dose limiting member relative to the drive sleeve.

公开(公告)号：US10105498B2

公开(公告)日：2018-10-23

申请号：US14783496

申请日：2014-04-08

申请人： Sanofi

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315 ,  A61M5/20 ,  A61M5/31

摘要： A drug delivery device for dispensing of a dose of a medicament includes a housing extending in an axial direction and a piston rod to operably engage with a piston of a cartridge to displace the piston in an axial distal direction. The drug delivery device includes a dose indicating mechanism including a first spool and a second spool rotatably supported in the housing and a dose indicating tape coiled onto at least the second spool and fixed with an end to an outer circumference of the first spool. The first and second spools are oriented substantially parallel to each other and substantially parallel to the piston rod.

公开(公告)号：US20160067417A1

公开(公告)日：2016-03-10

申请号：US14782705

申请日：2014-04-08

申请人： SANOFI

发明人： Stefan Bayer ,  Daniel Berning ,  Philippe Blank ,  Wolfgang Pelzer ,  Björn Wilden

IPC分类号： A61M5/315

CPC分类号： A61M5/31548 ,  A61M5/2033 ,  A61M5/31541 ,  A61M5/31553 ,  A61M5/31558 ,  A61M5/31563 ,  A61M5/3157 ,  A61M5/31575 ,  A61M5/3158 ,  A61M5/31583 ,  A61M5/31585 ,  A61M5/31591 ,  A61M5/31593 ,  A61M2005/202 ,  A61M2005/2086 ,  A61M2005/3126 ,  A61M2005/314 ,  A61M2005/3143 ,  A61M2005/31508 ,  A61M2005/3152 ,  A61M2005/3154 ,  A61M2205/581

摘要： Handheld drug injection device (10) for setting and dispensing of a dose of a medicament, having a housing (20) extending in an axial direction (1, 2) and a dose setting and drive mechanism (3) comprising: —a rotatable dose setting member (50) in a sidewall of the housing and engaging two dose indicating wheels (54,56), —a drive member (70) axially displaceable relative to a drive spindle (80) and the housing against the action of a spring element (78) during dose setting and having a sleeve-shaped part (72) being threadedly engaged with the drive spindle (80) to form a spindle gear, and having a rack portion (71) engaged with a gear wheel (58) of the dose setting member, —the drive spindle (80) being linked on its proximal end to a ratchet mechanism (140,150) which is releasable via an axially shiftable trigger button (40) for dose dispensing, and on its distal end via a pinion (86) to a —drive sleeve (90), the latter being axially shiftable to form a clutch for engagement with —a threaded piston rod (120), which engages a piston (14) of a cartridge (12) to displace the piston (14) in a distal axial direction (1), the trigger button (40) releasing the ratchet holding the drive spindle (80) to free it for rotation, and closing the clutch between drive sleeve (90) and piston rod (120), such that the drive spring (78) can push the drive member (70) forward, thereby rotating the spindle (80), which in turn rotates the drive sleeve (90), which in turn produces spiral forward movement of the piston rod (120). A dose limiter element (130) is also included between piston rod and coaxial drive sleeve.

摘要翻译： 用于设置和分配药物剂量的手持药物注射装置（10），其具有沿轴向方向（1,2）延伸的壳体（20）和剂量设定和驱动机构（3），包括： - 可旋转剂量 设置构件（50）在壳体的侧壁中并且接合两个剂量指示轮（54,56）， - 驱动构件（70）可相对于驱动轴（80）轴向移位，并且抵抗弹簧元件 （78），并且具有与所述驱动主轴（80）螺纹接合的套筒形部件（72）以形成主轴齿轮，并且具有与所述驱动轴（80）的齿轮（58）接合的齿条部分（71） 驱动轴（80）在其近端处连接到棘爪机构（140,150），该棘轮机构可通过用于剂量分配的可轴向移动的触发按钮（40）可释放，并且其远端经由小齿轮（86 ）到驱动套筒（90），后者可轴向移动以形成用于接合的离合器 h螺纹活塞杆（120），其与筒（12）的活塞（14）接合以沿远端轴向方向（1）移动活塞（14），触发按钮（40）释放保持 驱动主轴（80）以使其旋转，并且关闭驱动套筒（90）和活塞杆（120）之间的离合器，使得驱动弹簧（78）可以向前推动驱动构件（70），从而使主轴 （80），其又使驱动套筒（90）旋转，其又产生活塞杆（120）的螺旋向前运动。 活塞杆和同轴驱动套筒之间还包括剂量限制器元件（130）。