公开(公告)号：US20240287606A1

公开(公告)日：2024-08-29

申请号：US18475498

申请日：2023-09-27

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Richard Dannebaum ,  Khai Luong ,  Florian Rubelt ,  Dilduz Telman

IPC: C12Q1/6881

CPC classification number: C12Q1/6881

Abstract: The disclosure includes methods and compositions for accurately detecting subject's immune cell repertoire based on sequencing genomic DNA of immune cells.

公开(公告)号：US11929147B2

公开(公告)日：2024-03-12

申请号：US16646962

申请日：2018-09-12

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Darya Filippova ,  Khai Luong ,  Garima Kushwaha

IPC: G16B30/00 ,  G16B20/20 ,  C12Q1/6883

CPC classification number: G16B30/00 ,  G16B20/20 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: Described herein are methods for identifying quasispecies of genomes by clustering sequence reads for samples including the genomes based on the similarities of the sequence reads.

公开(公告)号：US11773511B2

公开(公告)日：2023-10-03

申请号：US16996733

申请日：2020-08-18

Applicant: Roche Sequencing Solutions, Inc

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C40B50/06 ,  C12Q1/68 ,  C12Q1/6881 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: C40B50/06 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q1/68 ,  C12Q2525/161 ,  C12Q2525/186 ,  C12Q2537/143

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US12043919B2

公开(公告)日：2024-07-23

申请号：US18400744

申请日：2023-12-29

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C40B50/06 ,  C12N15/10 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886

CPC classification number: C40B50/06 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/16

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US20220259667A1

公开(公告)日：2022-08-18

申请号：US17597760

申请日：2020-07-20

Applicant: Roche Sequencing Solutions, Inc.

Inventor： David Kurtz ,  Hai Lin ,  Alexander Lovejoy ,  Khai Luong ,  Ehsan Tabari

IPC: C12Q1/6886 ,  G16B20/20 ,  G16B40/20

Abstract: The present invention relates generally to classification of biological samples, and more specifically to cell of original classification. In particular, some embodiments of the invention relate to diffuse large B cell lymphoma cell of origin classification using machine learning models. The machine learning models can be based on decision trees such as a random forest algorithm or a gradient boosted decision tree. Features for the models can be determined through analysis of variant data from plasma or blood samples from a plurality of subjects with the disease.

公开(公告)号：US20210172015A1

公开(公告)日：2021-06-10

申请号：US16996733

申请日：2020-08-18

Applicant: Roche Sequencing Solutions, Inc

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C12Q1/6881 ,  C12N15/10 ,  C40B50/06 ,  C12Q1/68 ,  C12Q1/6886

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.