公开(公告)号：US11306356B2

公开(公告)日：2022-04-19

申请号：US16306397

申请日：2017-06-01

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Brian Godwin ,  Carolina Dallett ,  Sedide Ozturk ,  Joseph Platzer ,  Seoyoung Kim

IPC: C12Q1/6881 ,  C12Q1/68 ,  C40B50/06 ,  C12N15/10 ,  C12Q1/6886

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US11603565B2

公开(公告)日：2023-03-14

申请号：US17252222

申请日：2019-06-14

Applicant: Roche Sequencing Solutions, Inc. ,  Ventana Medical Systems, Inc.

Inventor： Nelson R. Alexander ,  Aoune Barhoumi ,  Jan Berka ,  Rui Chen ,  Lisa L. Gallegos ,  Toumy Guettouche ,  Seoyoung Kim ,  Maeve E. O'Huallachain ,  Sedide Ozturk ,  Jigar Patel ,  Florian Rubelt ,  Stacey Stanislaw

IPC: C12Q1/6883 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6881

Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

公开(公告)号：US20210285049A1

公开(公告)日：2021-09-16

申请号：US17252222

申请日：2019-06-14

Applicant: Roche Sequencing Solutions, Inc. ,  Ventana Medical Systems, Inc.

Inventor： Nelson R. Alexander ,  Aoune Barhoumi ,  Jan Berka ,  Rui Chen ,  Lisa L. Gallegos ,  Toumy Guettouche ,  Seoyoung Kim ,  Maeve E. O'Huallachain ,  Sedide Ozturk ,  Jigar Patel ,  Florian Rubelt ,  Stacey Stanislaw

IPC: C12Q1/6883 ,  C12Q1/6806 ,  C12N15/10 ,  C12Q1/6881

Abstract: The invention is a method of identifying a cognate antigen for a T-cell receptor using neoantigens from a patient's tumor cells combined with the patient's T-cells and using cell sorting, genome sequencing, expressing TCR genes, presenting tumor neoantigens on MHC complex and uniquely barcoding the T-cells where TCR recognition occurs to tag all components of the TCR recognition complex.

公开(公告)号：US11773511B2

公开(公告)日：2023-10-03

申请号：US16996733

申请日：2020-08-18

Applicant: Roche Sequencing Solutions, Inc

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C40B50/06 ,  C12Q1/68 ,  C12Q1/6881 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: C40B50/06 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q1/68 ,  C12Q2525/161 ,  C12Q2525/186 ,  C12Q2537/143

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US11725307B2

公开(公告)日：2023-08-15

申请号：US17307912

申请日：2021-05-04

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Brian Godwin ,  Carolina Dallett ,  Sedide Ozturk ,  Joseph Platzer ,  Seoyoung Kim

IPC: C40B50/06 ,  C12Q1/68 ,  C12Q1/6881 ,  C12N15/10 ,  C12Q1/6886

CPC classification number: C40B50/06 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q1/68 ,  C12Q2525/161 ,  C12Q2525/186 ,  C12Q2537/143

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US20180087108A1

公开(公告)日：2018-03-29

申请号：US15611507

申请日：2017-06-01

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Brian Godwin ,  Carolina Dallett ,  Sedide Ozturk ,  Joseph Platzer ,  Seoyoung Kim

IPC: C12Q1/68 ,  C12N15/10

CPC classification number: C12Q1/6881 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6886 ,  C12Q2600/16 ,  C12Q2525/161 ,  C12Q2525/186 ,  C12Q2537/143

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US12043919B2

公开(公告)日：2024-07-23

申请号：US18400744

申请日：2023-12-29

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C40B50/06 ,  C12N15/10 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886

CPC classification number: C40B50/06 ,  C12N15/1065 ,  C12Q1/68 ,  C12Q1/6881 ,  C12Q1/6886 ,  C12Q2600/16

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US11098360B2

公开(公告)日：2021-08-24

申请号：US15611507

申请日：2017-06-01

Applicant: Roche Sequencing Solutions, Inc.

Inventor： Jan Berka ,  Brian Godwin ,  Carolina Dallett ,  Sedide Ozturk ,  Joseph Platzer ,  Seoyoung Kim

IPC: C40B50/06 ,  C12Q1/6881 ,  C12Q1/68 ,  C12N15/10 ,  C12Q1/6886

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.

公开(公告)号：US20210172015A1

公开(公告)日：2021-06-10

申请号：US16996733

申请日：2020-08-18

Applicant: Roche Sequencing Solutions, Inc

Inventor： Jan Berka ,  Carolina Dallett ,  Richard Dannebaum ,  Brian Godwin ,  Seoyoung Kim ,  Jainee Lewis ,  Khai Luong ,  Sedide Ozturk ,  Joseph Platzer ,  Florian Rubelt ,  Dilduz Telman

IPC: C12Q1/6881 ,  C12N15/10 ,  C40B50/06 ,  C12Q1/68 ,  C12Q1/6886

Abstract: Methods and compositions are described herein for primer extension target enrichment of immune receptor (BCR or TCR) sequences.