公开(公告)号：US20220259667A1

公开(公告)日：2022-08-18

申请号：US17597760

申请日：2020-07-20

Applicant: Roche Sequencing Solutions, Inc.

Inventor： David Kurtz ,  Hai Lin ,  Alexander Lovejoy ,  Khai Luong ,  Ehsan Tabari

IPC: C12Q1/6886 ,  G16B20/20 ,  G16B40/20

Abstract: The present invention relates generally to classification of biological samples, and more specifically to cell of original classification. In particular, some embodiments of the invention relate to diffuse large B cell lymphoma cell of origin classification using machine learning models. The machine learning models can be based on decision trees such as a random forest algorithm or a gradient boosted decision tree. Features for the models can be determined through analysis of variant data from plasma or blood samples from a plurality of subjects with the disease.