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1.发明申请公开(公告)号：US20230094049A1
公开(公告)日：2023-03-30
申请号：US18061675
申请日：2022-12-05
发明人： Sven Ebert , Paul Federer , Pius Hermann , Stefan Vollenweider
摘要： A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
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2.发明授权公开(公告)号：US11517905B2
公开(公告)日：2022-12-06
申请号：US16516062
申请日：2019-07-18
发明人： Sven Ebert , Paul Federer , Pius Hermann , Stefan Vollenweider
摘要： A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
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公开(公告)号：US12066311B2
公开(公告)日：2024-08-20
申请号：US17456946
申请日：2021-11-30
摘要： The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.
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公开(公告)号：US20180095046A1
公开(公告)日：2018-04-05
申请号：US15717720
申请日：2017-09-27
摘要： A sensor (100) for detecting a state of a fluid within a microfluidic plate (120) is disclosed. The sensor (100) comprises at least a first planar electrode (102) and a second planar electrode (104) arranged parallel to one another so as to form an electric capacitor (106). The first planar electrode (102) and the second planar electrode (104) are configured to generate an electric field (114) within the fluid, wherein the sensor (100) is configured to detect the state of the fluid by means of a capacitance of the electric capacitor (106). Further, a system (116) for controlling a preparation of a sample including a fluid is disclosed. Furthermore, a method for detecting a state of a fluid within a microfluidic plate (120) is disclosed.
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公开(公告)号：US20180056297A1
公开(公告)日：2018-03-01
申请号：US15693009
申请日：2017-08-31
CPC分类号： B01L7/52 , B01L3/5085 , B01L9/06 , B01L2200/025 , B01L2300/0829 , B01L2300/1805 , B01L2300/1822 , B01L2300/1894 , C12P19/34 , H01L23/38 , H01L27/16 , H05B3/10
摘要： An assembly (10) comprising a sample block (12), a heat sink (30) and at least one electrodeposited thermoelectric element (48) is disclosed. Further, an instrument and a method for performing a temperature-dependent reaction are disclosed.
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6.发明公开公开(公告)号：US20240158118A1
公开(公告)日：2024-05-16
申请号：US18511844
申请日：2023-11-16
发明人： Paul Federer , Pius Hermann , Stefan Vollenweider
CPC分类号： B65B51/10 , B65B57/00 , B65B2051/105
摘要： A method for monitoring the sealing of a container in a system or device is described. The method includes the following steps: controlling the heating element to heat a heating stamp to a predetermined sealing temperature, monitoring the temperature of the heating stamp, determining a temperature over time curve of the heating stamp by means of at least one temperature sensor, determining at least one characteristic of the temperature over time curve, comparing the determined at least one characteristic of the temperature over time curve with a reference value, and determining a sealing property of the sealing of the container based on said comparison of the determined at least one characteristic of the temperature over time curve with the reference value.
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公开(公告)号：US20220170769A1
公开(公告)日：2022-06-02
申请号：US17456946
申请日：2021-11-30
IPC分类号： G01F1/58
摘要： The present disclosure provides for a sensor system for determining a flow rate of a fluid flow within a fluid channel comprising an elastic segment arranged next to a rigid segment, wherein a first pair of electrodes is provided at the rigid segment and a second pair of electrodes is provided at the elastic segment of the fluid channel. The system further comprises a sensor unit for detecting a capacitance of the first and second electrode pairs, and a processing unit for calculating and monitoring a distance between the electrodes of the second electrode pair based on the detected capacitance of the first electrode pair and the second electrode pair, wherein the first electrode pair is in contact with the rigid segment and the second electrode pair is in contact with the elastic segment. Moreover, a respective method for determining a flow rate of a fluid flow within a fluid channel is provided by the present disclosure, as well as a use of the sensor system.
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公开(公告)号：US20220168744A1
公开(公告)日：2022-06-02
申请号：US17673116
申请日：2022-02-16
发明人： Thomas Schlaubitz , Torsten Burdack , Paul Federer , Christian George , Guido Grueter , Andreas Scholle , Guenter Tenzler
IPC分类号： B01L7/00
摘要： The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format.
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9.发明申请公开(公告)号：US20200030807A1
公开(公告)日：2020-01-30
申请号：US16516062
申请日：2019-07-18
发明人： Sven Ebert , Paul Federer , Pius Hermann , Stefan Vollenweider
摘要： A method to monitor and control the temperature of a sample holder of a laboratory instrument during execution of a temperature profile on the sample holder is presented. The laboratory instrument comprises a sample holder with high temperature uniformity and at least three identical temperature sensors. The measured actual temperatures of the sample holder are processed in order to determine if the execution of the temperature profile should be continued or aborted. Furthermore, temperature sensors which measure actual temperatures that do not fulfil certain requirements are excluded from further monitoring and controlling the temperature of a sample holder.
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公开(公告)号：US20190070611A1
公开(公告)日：2019-03-07
申请号：US16058135
申请日：2018-08-08
发明人： Thomas Schlaubitz , Torsten Burdack , Paul Federer , Christian George , Guido Grueter , Andreas Scholle , Guenter Tenzler
IPC分类号： B01L7/00
摘要： The present invention relates to the field of high throughput analysis of samples. In particular, the present invention is directed to a device, a System and a method for simultaneous tempering of multiple samples. More particular, the invention relates to the simultaneous thermocycling of multiple samples to perform PCR in a microtiter plate format.
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