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公开(公告)号：US08975193B2
公开(公告)日：2015-03-10
申请号：US13196421
申请日：2011-08-02
Applicant: Robert Johnstone , Stephane Martel
Inventor： Robert Johnstone , Stephane Martel
CPC classification number: B81C1/00182 , B81B2201/054 , B81C2201/019 , B81C2203/0735
Abstract: A microfabricated device is fabricated by depositing a first metal layer on a substrate to provide a first electrode of an electrostatic actuator, depositing a first structural polymer layer over the first metal layer, depositing a second metal layer over said first structural polymer layer to form a second electrode of the electrostatic actuator, depositing an insulating layer over said first structural polymer layer, planarizing the insulating layer, etching the first structural polymer layer through the insulating layer and the second metal layer to undercut the second metal layer, providing additional pre-formed structural polymer layers, at least one of which has been previously patterned, and finally bonding the additional structural layers in the form of a stack over the planarized second insulating layer to one or more microfluidic channels. The technique can also be used to make cross over channels in devices without electrostatic actuators, in which case the metal layers can be omitted.
Abstract translation: 通过在衬底上沉积第一金属层以提供静电致动器的第一电极，在第一金属层上方沉积第一结构聚合物层，在第一结构聚合物层上沉积第二金属层以形成微结构聚合物层 静电致动器的第二电极，在所述第一结构聚合物层上沉积绝缘层，平坦化绝缘层，通过绝缘层和第二金属层蚀刻第一结构聚合物层以切割第二金属层，从而提供额外的预成形 结构聚合物层，其中至少一个已经被预先图案化，并且最后将平坦化的第二绝缘层上的堆叠形式的附加结构层结合到一个或多个微流体通道。 该技术也可以用于在没有静电致动器的装置中跨越通道，在这种情况下可以省略金属层。
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公开(公告)号：US20130034467A1
公开(公告)日：2013-02-07
申请号：US13196421
申请日：2011-08-02
Applicant: Robert Johnstone , Stephane Martel
Inventor： Robert Johnstone , Stephane Martel
CPC classification number: B81C1/00182 , B81B2201/054 , B81C2201/019 , B81C2203/0735
Abstract: A microfabricated device is fabricated by depositing a first metal layer on a substrate to provide a first electrode of an electrostatic actuator, depositing a first structural polymer layer over the first metal layer, depositing a second metal layer over said first structural polymer layer to form a second electrode of the electrostatic actuator, depositing an insulating layer over said first structural polymer layer, planarizing the insulating layer, etching the first structural polymer layer through the insulating layer and the second metal layer to undercut the second metal layer, providing additional pre-formed structural polymer layers, at least one of which has been previously patterned, and finally bonding the additional structural layers in the form of a stack over the planarized second insulating layer to one or more microfluidic channels. The technique can also be used to make cross over channels in devices without electrostatic actuators, in which case the metal layers can be omitted.
Abstract translation: 通过在衬底上沉积第一金属层以提供静电致动器的第一电极，在第一金属层上方沉积第一结构聚合物层，在第一结构聚合物层上沉积第二金属层以形成微结构聚合物层 静电致动器的第二电极，在所述第一结构聚合物层上沉积绝缘层，平坦化绝缘层，通过绝缘层和第二金属层蚀刻第一结构聚合物层以切割第二金属层，从而提供额外的预成形 结构聚合物层，其中至少一个已经被预先图案化，并且最后将平坦化的第二绝缘层上的堆叠形式的附加结构层结合到一个或多个微流体通道。 该技术也可以用于在没有静电致动器的装置中跨越通道，在这种情况下可以省略金属层。
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公开(公告)号：US20130032210A1
公开(公告)日：2013-02-07
申请号：US13196385
申请日：2011-08-02
Applicant: Robert Johnstone , Stephane Martel
Inventor： Robert Johnstone , Stephane Martel
CPC classification number: F04B19/006 , F04B43/073 , Y10T137/0318
Abstract: An integrated microfluidic device has at least at least one active element controlled by pneumatic signals, and at least one electrostatic actuator integrated in the device for generating the pneumatic signals within the device from an external supply of pressure or vacuum. In one embodiment the pressure supply may be generated internally on chip using an integrated pump.
Abstract translation: 集成的微流体装置具有至少一个由气动信号控制的有源元件，以及集成在该装置中的至少一个静电致动器，用于从外部的压力或真空供应产生装置内的气动信号。 在一个实施例中，可以使用集成泵在片上内部产生压力供应。
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4.发明申请INTEGRATED MICROFLUIDIC CHECK VALVE AND DEVICE INCLUDING SUCH A CHECK VALVE 审中-公开集成微流控检查阀和包括这种检查阀的装置公开(公告)号：US20130032235A1
公开(公告)日：2013-02-07
申请号：US13196405
申请日：2011-08-02
Applicant: Robert Johnstone , Stephane Martel
Inventor： Robert Johnstone , Stephane Martel
CPC classification number: F16K99/0057 , F04B43/02 , F04B53/1062 , F16K99/0015 , F16K2099/008 , F16K2099/0094 , Y10T29/49405 , Y10T137/2224 , Y10T137/7837
Abstract: An integrated microfluidic check valve has a first chamber having inlet and outlet ports and divided by a barrier the said inlet and outlet ports into first and second subchambers. A membrane forms a wall of the first chamber and co-operates with the barrier to selectively permit and prevent fluid flow between the inlet and outlet ports. A second chamber adjoining the first chamber and has a wall formed by the membrane. A microfluidic channel establishes fluid communication between the second chamber and the first subchamber. The membrane deflects to permit fluid flow around the barrier when the pressure in the first subchamber is lower than the pressure in the second subchamber. Two such valves can be combined into a peristaltic pump.
Abstract translation: 集成的微流体止回阀具有第一室，其具有入口端口和出口端口，并且将所述入口端口和出口端口的屏障分隔成第一和第二子室。 膜形成第一室的壁并与阻挡层协作以选择性地允许和防止入口和出口之间的流体流动。 毗邻第一室的第二室，具有由膜形成的壁。 微流体通道在第二室和第一子室之间建立流体连通。 当第一子室中的压力低于第二子室中的压力时，膜偏转以允许围绕屏障的流体流动。 两个这样的阀可以组合成蠕动泵。
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公开(公告)号：US20050042676A1
公开(公告)日：2005-02-24
申请号：US10479855
申请日：2002-06-07
Applicant: Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
Inventor： Christian Hamon , Andrew Thompson , Karsten Kuhn , Thomas Neumann , Richard Joubert , Robert Johnstone , Gunier Schmidt
IPC: C07D213/71 , C07D215/36 , C07D239/38 , C07D241/18 , C07D251/58 , C07K1/107 , C07K1/12 , C12Q1/02 , C12Q1/37 , G01N33/68 , G01N33/53
CPC classification number: G01N33/6848 , C07K1/12 , G01N33/6821
Abstract: Provided is a method for characterising a polypeptide or a population of polypeptides, which method comprises the steps of: (a) contacting a sample comprising one or more polypeptides with a lysine reactive agent to cap ε-amino groups; (b) optionally reacting the sample of polypeptides with an amine reactive reagent to block α-amino groups; (c) digesting the sample of polypeptides with a cleavage reagent to produce peptide fragments; (d) optionally deactivating the cleavage reagent; (e) removing those peptides having uncapped or unblocked amino groups; and (f) recovering the N-terminal peptides.
Abstract translation: 提供了表征多肽或多肽群体的方法，该方法包括以下步骤：（a）将包含一种或多种多肽的样品与赖氨酸反应剂接触以将ε-氨基封端; （b）任选地使多肽样品与胺反应试剂反应以阻断α-氨基; （c）用裂解试剂消化多肽样品以产生肽片段; （d）任选地使切割试剂失活; （e）除去具有未封端或未封闭的氨基的那些肽; 和（f）回收N-末端肽。
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Patent Agency Ranking
公开(公告)号：US20050095741A1
公开(公告)日：2005-05-05
申请号：US10973568
申请日：2004-10-26
Applicant: Robert Johnstone , Robert Walker , Robert Griffin
Inventor： Robert Johnstone , Robert Walker , Robert Griffin
CPC classification number: G02B6/136 , G02B6/1228 , G02B6/126 , G02B2006/12097
Abstract: An improved method is provided for fabricating a polarisation rotator in a rib waveguide having a propagation axis and opposite side walls. The method includes etching a pit in the substrate surface to form a recess in one of the side walls of the waveguide, during formation of the waveguide on the substrate surface, so as to provide an asymmetric waveguide section for imparting polarisation rotation to radiation propagated along the propagation axis. Preferably the pit is formed by a wet etching step forming an upper side surface within the recess that is inclined relative the waveguide side walls, and the waveguide side walls are formed by a dry etching step to extend perpendicularly to the substrate surface. In addition the dry etching step forms a lower side surface adjoining the upper side surface within the recess and tilted relative to the upper side surface. Such a method is significantly simplified as compared with prior art production methods, as well as providing greater yield and more predictable device performance since mask alignment errors no longer affect the design parameters of the rotator.
Abstract translation: 提供了一种用于在具有传播轴和相对侧壁的肋波导中制造偏振旋转器的改进方法。 该方法包括在衬底表面上形成波导期间蚀刻衬底表面中的凹坑以在波导的一个侧壁中形成凹槽，以便提供用于使波长旋转对沿着 传播轴。 优选地，通过湿蚀刻步骤形成凹坑，该凹蚀形成在凹槽内相对于波导侧壁倾斜的上侧表面，并且波导侧壁通过干蚀刻步骤形成，以垂直于基底表面延伸。 此外，干蚀刻步骤形成与凹部内的上侧表面相邻并且相对于上侧表面倾斜的下侧表面。 与现有技术的制造方法相比，这种方法被显着简化，并且由于掩模对准误差不再影响转子的设计参数，因此提供更大的产量和更可预测的装置性能。
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7.发明授权公开(公告)号：US08746270B2
公开(公告)日：2014-06-10
申请号：US12703656
申请日：2010-02-10
Applicant: Bruce Patterson , Glenn Duke , Robert Johnstone
Inventor： Bruce Patterson , Glenn Duke , Robert Johnstone
IPC: F16K31/02
CPC classification number: G05D7/0635 , Y10T137/0368 , Y10T137/7759 , Y10T137/7761
Abstract: A method is provided for controllably delivering an additive fluid into a host fluid in a target system at a desired volumetric flow rate. The method comprises: providing a binary supply injector connected in an additive fluid delivery system between a pressurized supply of the additive fluid and the target system. The binary supply injector is controllable between an ON state which permits flow of the additive fluid therethrough and an OFF state which prevents flow of the additive fluid therethrough. The method involves iteratively repeating: estimating a volumetric flow rate of the additive fluid between the pressurized supply and the target system; and if the estimated volumetric flow rate of the additive fluid is greater than the desired volumetric flow rate, controlling the supply injector to its OFF state; or if the estimated volumetric flow rate of the additive fluid is less than the desired volumetric flow rate, controlling the supply injector to its ON state. Additive fluid delivery systems are also provided.
Abstract translation: 提供了一种用于以所需的体积流量可控地将添加剂流体输送到目标系统中的主体流体中的方法。 该方法包括：提供连接在附加流体输送系统中的加压供应的添加剂流体和目标系统之间的二进制供给喷射器。 二进制供给喷射器可以在允许添加剂流体流过其的ON状态和阻止添加剂流体通过其流动的OFF状态之间控制。 该方法涉及迭代重复：估计加压供应和目标系统之间的添加剂流体的体积流量; 并且如果所述添加剂流体的估计体积流量大于所需的体积流量，则将所述供给注射器控制到其关闭状态; 或者如果添加剂流体的估计体积流量小于期望的体积流量，则将供给喷射器控制到其接通状态。 还提供了添加剂输送系统。
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公开(公告)号：US20050147351A1
公开(公告)日：2005-07-07
申请号：US11005696
申请日：2004-12-06
Applicant: Robert Johnstone , Royston Powell , Robert Griffin , Robert Walker , Brian Buck
Inventor： Robert Johnstone , Royston Powell , Robert Griffin , Robert Walker , Brian Buck
CPC classification number: G02F1/3133
Abstract: An optical modulator comprises first and second optical waveguides having first and second electrodes respectively associated therewith, and an electrically conductive region associated with both waveguides. The electrodes have inputs for an electrical signal at input ends thereof, and outputs for the electrical signal at opposite output ends thereof. The conductive region is electrically connected to the output ends of the first and second electrodes such that an electric field created by the electrical signal between the first electrode and the conductive region is substantially equal in magnitude to an electric field created by the electrical signal between the second electrode and the conductive region. The balancing of the electric fields experienced by the waveguides enables the modulation of light in the two waveguides to be balanced. The modulator may be a Mach-Zehnder modulator, and the balanced modulation may result in amplitude modulation of the optical output of the modulator, generally without phase modulation.
Abstract translation: 光调制器包括具有分别与其相关联的第一和第二电极的第一和第二光波导以及与两个波导相关联的导电区域。 电极在其输入端具有用于电信号的输入，并且在其相对的输出端输出电信号。 导电区域电连接到第一和第二电极的输出端，使得由第一电极和导电区域之间的电信号产生的电场在幅度上基本上等于由电信号产生的电场 第二电极和导电区域。 波导经历的电场的平衡使得能够平衡两个波导中的光的调制。 调制器可以是马赫 - 策德尔（Mach-Zehnder）调制器，并且平衡调制可以导致调制器的光输出的幅度调制，通常没有相位调制。
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公开(公告)号：US20050095661A1
公开(公告)日：2005-05-05
申请号：US10479843
申请日：2002-06-07
Applicant: Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Mohammed
Inventor： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Mohammed
CPC classification number: G01N33/6848 , C07K1/12 , G01N33/6821
Abstract: Provided is a method for characterising a polypeptide, which method comprises the steps of; (a) optionnally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more ε-amino groups that are present with a lysine reactive agent; (e) analysing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.
Abstract translation: 提供一种表征多肽的方法，该方法包括以下步骤： （a）选择性地减少多肽中的半胱氨酸二硫桥以形成游离的硫醇，并且封端游离的硫醇; （b）用序列特异性切割试剂切割多肽以形成肽片段; （c）任选地使切割试剂失活; （d）封端与赖氨酸反应剂一起存在的一个或多个ε-氨基; （e）通过质谱分析肽片段以形成多肽的质量指纹图谱; 和（f）从质量指纹图谱确定多肽的身份。
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公开(公告)号：US07163803B2
公开(公告)日：2007-01-16
申请号：US10479843
申请日：2002-06-07
Applicant: Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
Inventor： Christian Hamon , Andrew Thompson , Thomas Neumann , Robert Johnstone , Abdul Karim Abed Mohammed
IPC: C12Q1/37
CPC classification number: G01N33/6848 , C07K1/12 , G01N33/6821
Abstract: Provided is a method for characterizing a polypeptide, which method comprises the steps of: (a) optionally reducing cysteine disulphide bridges in the polypeptide to form free thiols, and capping the free thiols; (b) cleaving the polypeptide with a sequence specific cleavage reagent to form peptide fragments; (c) optionally deactivating the cleavage reagent; (d) capping one or more ε-amino groups that are present with a lysine reactive agent; (e) analyzing peptide fragments by mass spectrometry to form a mass fingerprint for the polypeptide; and (f) determining the identity of the polypeptide from the mass fingerprint.
Abstract translation: 提供了表征多肽的方法，该方法包括以下步骤：（a）任选地减少多肽中的半胱氨酸二硫键形成游离硫醇，并封端游离硫醇; （b）用序列特异性切割试剂切割多肽以形成肽片段; （c）任选地使切割试剂失活; （d）封端与赖氨酸反应剂一起存在的一个或多个ε-氨基; （e）通过质谱分析肽片段以形成多肽的质量指纹图谱; 和（f）从质量指纹图谱确定多肽的身份。
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