公开(公告)号：US5998374A

公开(公告)日：1999-12-07

申请号：US808277

申请日：1997-02-28

申请人： Robert I. Lehrer ,  In-Hee Lee ,  Chengquan Zhao

发明人： Robert I. Lehrer ,  In-Hee Lee ,  Chengquan Zhao

IPC分类号： A61K38/00 ,  A61P43/00 ,  C07K14/435 ,  C12N15/12 ,  A61K38/17

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： Novel microbial peptides called clavaspirins are of the formula (SEQ ID NO:1)X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 U.sub.6 U.sub.7 X.sub.8 X.sub.9 B.sub.10 X'.sub.11 X.sub.12 U.sub.13 B.sub.14 X.sub.15 X.sub.16 B*.sub.17 B.sub.18 X.sub.19 U.sub.20 X.sub.21 X'.sub.22 X.sub.23 (1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof;B* is a basic or a hydrophobic amino acid residue or a modified form thereof; andU is a small amino acid residue or modified form thereof.

摘要翻译： 称为克拉斯匹林的新型微生物肽具有式（SEQ ID NO：1）X'1X2B'3X4X5U6U7X8X9B10X'11X12U13B14X15X16B * 17B18X19U20X21X'22X23（1），其包括其盐，酯，酰胺和酰化形式，其中X是疏水性氨基酸残基或 其修改形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式。

公开(公告)号：US6040293A

公开(公告)日：2000-03-21

申请号：US810324

申请日：1997-02-28

申请人： Robert I. Lehrer ,  Chengquan Zhao ,  In-Hee Lee

发明人： Robert I. Lehrer ,  Chengquan Zhao ,  In-Hee Lee

IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12 ,  C07K14/00 ,  A61K37/02

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： Novel microbial peptides called clavanins are of the formula[X'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 ]U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1)(SEQ ID NO:1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof; andB* is a basic or a hydrophobic amino acid residue or a modified form thereof;U is a small amino acid residue or modified form thereof;Z is a polar/large amino acid residue or modified form thereof, and wherein 1-5 amino acids is deleted from the N-terminus.

摘要翻译： 称为克拉维宁的新型微生物肽具有式[X'1X2B'3X4X5] U6B7X8X9B10B11X12U13Z14X15X16B * 17U18X19U20B21X22X23（1）（1）（SEQ ID NO：1），其包括其盐，酯，酰胺和酰化形式，其中X是疏水性氨基酸残基或经修饰 形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式; Z是极性/大的氨基酸残基或其修饰形式，其中1-5个氨基酸从N-末端缺失。

公开(公告)号：US6010876A

公开(公告)日：2000-01-04

申请号：US746160

申请日：1996-11-06

申请人： Robert I. Lehrer ,  Sylvia L. Harwig, deceased ,  Chengquan Zhao ,  In-Hee Lee

发明人： Robert I. Lehrer ,  Sylvia L. Harwig, deceased ,  Chengquan Zhao ,  In-Hee Lee

IPC分类号： A61K38/00 ,  C07K14/435 ,  C12N1/21 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： Novel microbial peptides called clavanins are of the formulaX'.sub.1 X.sub.2 B'.sub.3 X.sub.4 X.sub.5 U.sub.6 B.sub.7 X.sub.8 X.sub.9 B.sub.10 B.sub.11 X.sub.12 U.sub.13 Z.sub.14 X.sub.15 X.sub.16 B*.sub.17 U.sub.18 X.sub.19 U.sub.20 B.sub.21 X.sub.22 X.sub.23 ( 1)(SEQ ID NO: 1)including the salts, esters, amides and acylated forms thereofwherein X is a hydrophobic amino acid residue or modified form thereof;X' is a small or a hydrophobic amino acid residue or a modified form thereof;B is a basic amino acid residue or modified form thereof;B' is basic or a polar/large amino acid residue or modified form thereof; andB* is a basic or a hydrophobic amino acid residue or a modified form thereof;U is a small amino acid residue or modified form thereof;Z is a polar/large amino acid residue or modified form thereof.

摘要翻译： 称为克拉维宁的新型微生物肽具有式X'1X2B'3X4X5U6B7X8X9B10B11X12U13Z14X15X16B * 17U18X19U20B21X22X23（1）（1）（SEQ ID NO：1），其中X是疏水性氨基酸残基或其修饰形式; X'是小或疏水性氨基酸残基或其修饰形式; B是碱性氨基酸残基或其修饰形式; B'是碱性或极性/大氨基酸残基或其修饰形式; B *是碱性或疏水性氨基酸残基或其修饰形式; U是小氨基酸残基或其修饰形式; Z是极性/大氨基酸残基或其修饰形式。

公开(公告)号：US07504380B2

公开(公告)日：2009-03-17

申请号：US10535624

申请日：2002-11-22

申请人： In-Hee Lee ,  Seok-Min Son ,  Woong-Sik Jang ,  Kyu-Nam Kim

发明人： In-Hee Lee ,  Seok-Min Son ,  Woong-Sik Jang ,  Kyu-Nam Kim

IPC分类号： A61K38/03

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong acidic and basic environments. Moreover, it also shows strong antimicrobial activity against resistant bacteria. So, it can be used usefully as a natural antimicrobial agent.

摘要翻译： 本发明涉及从Halocynthia aurantium分离的抗微生物肽，更具体地说，涉及从Halocynthia aurantium的体液中分离的抗微生物肽，以及含有它们作为活性成分的抗微生物剂。 本发明的抗微生物肽在强酸性和碱性环境下表现出优异的抗菌活性。 此外，它还显示出抗性细菌的强抗微生物活性。 因此，它可以有效地用作天然抗菌剂。

公开(公告)号：US09543155B2

公开(公告)日：2017-01-10

申请号：US14975932

申请日：2015-12-21

申请人： Bok-Young Lee ,  Yoo-Jung Lee ,  Dong-Hoon Khang ,  Do-Hyoung Kim ,  Cheol Kim ,  In-Hee Lee ,  Ji-Eun Han

发明人： Bok-Young Lee ,  Yoo-Jung Lee ,  Dong-Hoon Khang ,  Do-Hyoung Kim ,  Cheol Kim ,  In-Hee Lee ,  Ji-Eun Han

IPC分类号： H01L21/28 ,  H01L29/66 ,  H01L27/11

CPC分类号： H01L21/28132 ,  H01L27/1104 ,  H01L27/1116 ,  H01L29/66545

摘要： A method includes forming a first etch target layer and a first mask layer on a substrate. Sacrificial patterns extending in a first direction are formed on the first mask layer in a second direction. Spacers are formed on sidewalls of the sacrificial patterns. After removing the sacrificial patterns, the first mask layer is etched using the spacers as an etching mask to form first masks. Second masks are formed on sidewalls of each first mask to define a third masks including each first mask and the second masks on sidewalls of each first mask. The first etch target layer is etched using the first and third masks as an etching mask to form first and second patterns in the first and second regions, respectively. Each first pattern has a first width, and each second pattern has a second width greater than the first width.

摘要翻译： 一种方法包括在衬底上形成第一蚀刻目标层和第一掩模层。 在第一方向上在第一掩模层上形成沿第一方向延伸的牺牲图案。 垫片形成在牺牲图案的侧壁上。 在去除牺牲图案之后，使用间隔件作为蚀刻掩模来蚀刻第一掩模层以形成第一掩模。 第二掩模形成在每个第一掩模的侧壁上以限定包括每个第一掩模的第三掩模和在每个第一掩模的侧壁上的第二掩模。 使用第一和第三掩模蚀刻第一蚀刻目标层作为蚀刻掩模，以分别在第一和第二区域中形成第一和第二图案。 每个第一图案具有第一宽度，并且每个第二图案具有大于第一宽度的第二宽度。

公开(公告)号：US20080190688A1

公开(公告)日：2008-08-14

申请号：US11814261

申请日：2006-01-20

申请人： In-Hee Lee

发明人： In-Hee Lee

IPC分类号： H05K5/00

CPC分类号： H04R1/347 ,  H04R1/021

摘要： The present invention relates to speakers and, more particularly, to a speaker sound system, characterized in that the speaker, mounted on a speaker housing constituting a sound emission apparatus, has a guide cover to guide sound radiating from the back of the speaker forwards when the sound is output both forwards and backwards because of fluctuations of a cone of the speaker due to electrical signals, that is integrally attached to the surface of the speaker, thereby providing vivid high-fidelity sound.

摘要翻译： 本发明涉及扬声器，更具体地说，涉及一种扬声器音响系统，其特征在于，安装在构成声音发射装置的扬声器壳体上的扬声器具有引导盖，用于引导从扬声器背面辐射的声音， 由于由于电信号而扬声器的锥体的波动，声音被向前和向后输出，这被整体连接到扬声器的表面，从而提供生动的高保真声音。

公开(公告)号：US20060135748A1

公开(公告)日：2006-06-22

申请号：US10535624

申请日：2002-11-22

申请人： In-Hee Lee ,  Seok-Min Son ,  Woong-Sik Jang ,  Kyu-Nam Kim

发明人： In-Hee Lee ,  Seok-Min Son ,  Woong-Sik Jang ,  Kyu-Nam Kim

IPC分类号： C07K14/435

CPC分类号： C07K14/43504 ,  A61K38/00

摘要： The present invention relates to an antimicrobial peptide isolated from Halocynthia aurantium, more particularly, to an antimicrobial peptide isolated from the body fluid of Halocynthia aurantium and an antimicrobial agent comprising the same as an active ingredient. The antimicrobial peptide of the present invention shows excellent antimicrobial activity under strong acidic and basic environments. Moreover, it also shows strong antimicrobial activity against resistant bacteria. So, it can be used usefully as a natural antimicrobial agent.

公开(公告)号：US06748196B2

公开(公告)日：2004-06-08

申请号：US09771988

申请日：2001-01-30

申请人： Kon-Hee Lee ,  In-Hee Lee

发明人： Kon-Hee Lee ,  In-Hee Lee

IPC分类号： H04B100

CPC分类号： H04W52/52

摘要： A transmit output controlling circuit and method of a wireless mobile communication system comprises a demodulating portion for detecting an immediate frequency of a receive information induced through an antenna and passing through a duplexer portion; a receive sensitivity measuring portion for detecting a receive sensitivity level of the immediate frequency signal detected by the demodulating portion; a controller for receiving data from the demodulating portion and outputting a receive sensitivity data, a timing control signal and a transmit power control signal; a transmit signal control a receive sensitivity data into a transmit signal according to the receive sensitivity data and the timing control signal from the controller; a transmit output amplifying portion for amplifying the transmit signal from the transmit signal control; and a transmit power control for controlling an amplification factor of the transmit output amplifying portion according to the control signal from the controller, so that the transmit output level is controlled according to the receive sensitivity and the communication distance, thereby reducing the power consumption in a local communication.

摘要翻译： 发射输出控制电路和无线移动通信系统的方法包括：解调部分，用于检测通过天线感应并通过双工器部分的接收信息的即时频率; 接收灵敏度测量部分，用于检测由解调部分检测到的立即频率信号的接收灵敏度; 控制器，用于从解调部分接收数据并输出接收灵敏度数据，定时控制信号和发射功率控制信号; 发送信号根据来自控制器的接收灵敏度数据和定时控制信号将接收灵敏度数据控制为发送信号; 发射输出放大部分，用于放大来自发射信号控制的发射信号; 以及发射功率控制，用于根据来自控制器的控制信号来控制发射输出放大部分的放大系数，使得根据接收灵敏度和通信距离来控制发射输出电平，从而降低发射输出放大部分的功率消耗 本地通讯。