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1.发明授权PSCA: prostate stem cell antigen and distinguishing androgen receptor negative prostate cancer from benign prostatic hyperplasia 有权PSCA：前列腺干细胞抗原和区分雄激素受体阴性前列腺癌与良性前列腺增生公开(公告)号：US08759006B2
公开(公告)日：2014-06-24
申请号：US12169561
申请日：2008-07-08
Applicant: Robert E. Reiter , Owen N. Witte
Inventor： Robert E. Reiter , Owen N. Witte
IPC: G01N33/53 , G01N33/567 , G01N33/574
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过度表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。
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公开(公告)号：US07595431B2
公开(公告)日：2009-09-29
申请号：US11531212
申请日：2006-09-12
Applicant: Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
Inventor： Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
CPC classification number: A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
Abstract translation: 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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3.发明申请PSCA: PROSTATE STEM CELL ANTIGEN AND USES THEREOF 有权PSCA：PROSTATE STEM CELL ANTIGEN AND USES THEREOF公开(公告)号：US20090104631A1
公开(公告)日：2009-04-23
申请号：US12169561
申请日：2008-07-08
Applicant: Robert E. Reiter , Owen N. Witte , Douglas C. Saffran , Aya Jakobovits
Inventor： Robert E. Reiter , Owen N. Witte , Douglas C. Saffran , Aya Jakobovits
IPC: G01N33/574 , C07K16/00
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。
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公开(公告)号：US07053263B2
公开(公告)日：2006-05-30
申请号：US10022115
申请日：2001-12-14
Applicant: Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
Inventor： Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
CPC classification number: A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
Abstract translation: 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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公开(公告)号：US06828471B2
公开(公告)日：2004-12-07
申请号：US10062925
申请日：2002-01-30
Applicant: Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
Inventor： Charles L. Sawyers , Karen A. Klein , Owen N. Witte , Robert E. Reiter
IPC: A01K6700
CPC classification number: A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
Abstract: The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
Abstract translation: 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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Patent Agency Ranking
公开(公告)号：US06790939B2
公开(公告)日：2004-09-14
申请号：US09855632
申请日：2001-05-14
Applicant: Robert E. Reiter , Owen N. Witte , Douglas C. Saffran , Aya Jakobovits
Inventor： Robert E. Reiter , Owen N. Witte , Douglas C. Saffran , Aya Jakobovits
IPC: C07K1600
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。
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公开(公告)号：US06541212B2
公开(公告)日：2003-04-01
申请号：US09564329
申请日：2000-05-03
Applicant: Robert E. Reiter , Owen N. Witte
Inventor： Robert E. Reiter , Owen N. Witte
IPC: G01N3353
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. The invention also provides a method for detecting a Prostate Stem Cell Antigen (PSCA) protein of bone (SEQ ID NO:2), comprising obtaining a sample; contacting the sample with an antibody that recognizes and binds the PSCA protein; and, detecting binding of the antibody with the PSCA protein in the sample.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。 本发明还提供了一种用于检测骨的前列腺干细胞抗原（PSCA）蛋白质（SEQ ID NO：2）的方法，包括获得样品; 使样品与识别并结合PSCA蛋白的抗体接触; 并检测样品中抗体与PSCA蛋白的结合。
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公开(公告)号：US06258939B1
公开(公告)日：2001-07-10
申请号：US09203939
申请日：1998-12-02
Applicant: Robert E. Reiter , Owen N. Witte
Inventor： Robert E. Reiter , Owen N. Witte
IPC: C07K1630
CPC classification number: C07K16/3069 , A61K2039/505 , C07K14/4748 , C07K14/705 , G01N33/57434
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。
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公开(公告)号：US08524460B2
公开(公告)日：2013-09-03
申请号：US13083205
申请日：2011-04-08
Applicant: Robert E. Reiter , Owen N. Witte
Inventor： Robert E. Reiter , Owen N. Witte
IPC: G01N33/53 , G01N33/574 , C07K16/00 , C07K17/00 , C12P21/08
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
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公开(公告)号：US07462691B2
公开(公告)日：2008-12-09
申请号：US10997735
申请日：2004-11-23
Applicant: Robert E. Reiter , Owen N. Witte
Inventor： Robert E. Reiter , Owen N. Witte
CPC classification number: C07K16/3069 , A01K2217/05 , A61K31/704 , A61K38/00 , A61K39/395 , A61K39/39558 , A61K45/06 , A61K47/6869 , A61K51/106 , A61K51/1072 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K16/30 , C07K16/3038 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/53 , G01N33/567 , G01N33/574 , G01N33/57407 , G01N33/57434 , G01N33/57438 , G01N33/577 , G01N2333/705 , A61K31/00 , A61K2300/00
Abstract: The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors.
Abstract translation: 本发明提供了一种新的前列腺细胞表面抗原，其命名为前列腺干细胞抗原（PSCA），其在前列腺癌的所有阶段中广泛过表达，包括高级前列腺上皮内瘤变（PIN），雄激素依赖性和雄激素依赖性 前列腺肿瘤。
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