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公开(公告)号：US11518971B2
公开(公告)日：2022-12-06
申请号：US16695550
申请日：2019-11-26
摘要： A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.
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公开(公告)号：US10292909B2
公开(公告)日：2019-05-21
申请号：US15918026
申请日：2018-03-12
发明人： Leah Marie Johnson , Ginger Denison Rothrock , Sarah Dorothy Shepherd , Sandra Cordel O'Buckley , Andrea Gail Neely
摘要： The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
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公开(公告)号：US20230069918A1
公开(公告)日：2023-03-09
申请号：US17795476
申请日：2021-01-26
发明人： Leah Marie Johnson , Nicolas Daniel Huffman , Jeffrey Brent Mecham , Ian Edward Stewart , Natalie Marie Girouard
IPC分类号： C08G59/50
摘要： The present disclosure relates to delivery and release compositions, systems, and methods of use thereof. In particular, the present disclosure relates to degradable polymeric systems including a first epoxy-containing monomer and a second, different epoxy-containing monomer, wherein the degradable polymeric system is crosslinked, and wherein one of the first epoxy-containing monomer and the second, different epoxy-containing monomer includes one or more ester groups; delivery systems incorporating degradable polymeric systems; and methods for providing cargo to a petroleum reservoir.
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公开(公告)号：US09943466B1
公开(公告)日：2018-04-17
申请号：US15622238
申请日：2017-06-14
发明人： Leah Marie Johnson , Ginger Denison Rothrock , Sarah Dorothy Shepherd , Sandra Cordel O'Buckley , Andrea Gail Neely
CPC分类号： A61K6/0067 , A61K6/0002 , A61K9/0002 , A61K9/1647 , A61K47/42 , A61K2300/00
摘要： The disclosure provides biocompatible dental material that is moldable and biodegradable and provides sustained and/or controlled delivery of one or more local anesthetics within a dental cavity or space. Such dental material is customizable for the size and shape needed for a particular patient or particular application. The dental material may also provide customizable sustained and/or controlled delivery of one or more local anesthetics.
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公开(公告)号：US20160186044A1
公开(公告)日：2016-06-30
申请号：US14911542
申请日：2014-08-12
CPC分类号： C09K8/588 , B01J13/14 , B82Y30/00 , B82Y40/00 , C09K8/03 , C09K8/516 , C09K8/536 , C09K8/58 , C09K8/584 , C09K8/70 , C09K8/92 , C09K2208/10 , E21B43/16
摘要： The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a carrier element forming an outer shell that defines an inner core. The core can include a reactive agent that is adapted to react with the shell, particularly at an inner interface of the shell with the core materials. The reaction can provide an inside-out degradation of the shell and release of one or more materials therein. The reactive agent may be separated from the shell, such as using a phase change material (PCM). Upon reaching specific environmental conditions, the PCM can change so as the release the reactive agent for reaction with the shell. The systems can be used in various methods to deliver a material to various environments, including underground reservoirs.
摘要翻译： 本公开涉及递送和释放系统，例如核 - 壳颗粒。 根据本公开的示例性组合物可以包括形成限定内芯的外壳的载体元件。 核心可以包括适于与壳体反应的反应剂，特别是在壳体与芯材料的内部界面处。 反应可以提供外壳的内向退化和其中的一种或多种材料的释放。 反应剂可以与壳分离，例如使用相变材料（PCM）。 在达到特定的环境条件时，PCM可以改变，以释放与壳反应的反应剂。 这些系统可以以各种方法用于将材料递送到各种环境，包括地下储层。
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公开(公告)号：US11078411B2
公开(公告)日：2021-08-03
申请号：US16071024
申请日：2017-01-17
发明人： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Sarah Dorothy Shepherd , Nicolas Daniel Huffman , Jeffrey Brent Mecham
摘要： The present disclosure relates to delivery and release systems wherein a plurality of particles is provided, and the particles are formed of a vehicle component and a cargo component. The systems and methods particularly can be useful in delivery of various chemicals to a petroleum reservoir. The vehicle component can undergo a change in situ such that at least a portion of the cargo component is released.
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公开(公告)号：US20200165555A1
公开(公告)日：2020-05-28
申请号：US16695550
申请日：2019-11-26
摘要： A three-dimensional cell growth containment article is described, which includes a molded body channelized by removal of sacrificial channelizing element(s) therefrom, so that the molded body contains one or more channel(s) therein, with a matrix material in at least one of such channel(s) that is supportive of three-dimensional cell growth in the matrix material. A method for making such articles is also described, in which a molded body is formed with one or more sacrificial channelizing element(s) therein, following which the sacrificial channelizing element(s) are removed. The three-dimensional cell growth containment articles of the present disclosure may be utilized in any applications in which there exists a need to reproducibly generate three-dimensional cellular structures, e.g., islet transplantation for diabetes treatment, transplantation of hormone secreting cells, cellular scaffolds for wound healing, and generation of tissue engineering structures to regain structural usefulness for orthopedic applications.
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公开(公告)号：US20170369766A1
公开(公告)日：2017-12-28
申请号：US15634340
申请日：2017-06-27
发明人： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
IPC分类号： C09K8/588 , E21B33/138 , E21B43/20
摘要： The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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公开(公告)号：US12110451B2
公开(公告)日：2024-10-08
申请号：US17355828
申请日：2021-06-23
发明人： Leah Marie Johnson , Ginger Denison Rothrock , Chasity Antoninette Norton , Nicolas Daniel Huffman , Jeffrey Brent Mecham
CPC分类号： C09K8/588 , C09K8/508 , C09K8/512 , C09K8/516 , E21B33/138 , E21B43/20 , C09K2208/10
摘要： The present disclosure relates to delivery and release systems, such as core-shell particles. An exemplary composition according to the disclosure can include a degradable polymeric shell surrounding a core that includes a crosslinker, which can encompass a metal, such as chromium. The core-shell particles can be provided with a gel-forming polymer, such as a polyacrylamide, into a subterranean reservoir having conditions such that the shell of the core-shell polymer degrades, and the so-released metal is effective to at least partially crosslink the gel-forming polymer to form a gel. The so-formed gel can be effective to control water flow through the subterranean reservoir, such as in relation to a waterflood of the reservoir.
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公开(公告)号：US11828685B2
公开(公告)日：2023-11-28
申请号：US17184887
申请日：2021-02-25
CPC分类号： G01N1/10 , C08J9/32 , C08K7/28 , G01N33/1886 , G01N33/2858 , C08J2363/00
摘要： Syntactic foams are materials including hollow microspheres distributed throughout a cured polymeric resin. Hollow microspheres within syntactic foams, including collapsible shells that enclose empty cavities, can serve as receptacles to capture environmental constituents upon applied temperature and pressure. An epoxy formulation including of EPON™ 828, HELOXY™ 61, and TETA was combined with hollow glass microspheres with isostatic crush strengths of 300, 3000, and 10,000 psi. Effects of pressure and temperature on the mechanical properties were evaluated via dynamic mechanical analysis. Storage modulus and glass transition temperature depended on formulation. Upon exposure to specific temperature and pressures, the hollow glass spheres embedded within the resin lose mechanical integrity and collapse, resulting in the generation of unencapsulated void spaces, primed to capture embedded liquid. Controllable loss of mechanical integrity enables syntactic foams to serve as on-demand receptacles to retain constituents in the surrounding environment, resulting from externally triggered pressures and temperatures.
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