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    Vapor fueled engine
    2.
    发明申请
    Vapor fueled engine 失效
    汽油发动机

    公开(公告)号：US20050145226A1

    公开(公告)日：2005-07-07

    申请号：US11073050

    申请日：2005-03-04

    申请人： Raymond Bushnell ,  Danny Lewis

    发明人： Raymond Bushnell ,  Danny Lewis

    IPC分类号： F02D41/00 ,  F02M17/20 ,  F02M31/18 ,  F02G5/00

    CPC分类号： F02M17/20 ,  F02D41/003 ,  F02D41/1459 ,  F02M31/18 ,  F02M31/183 ,  Y02T10/126

    摘要： A fuel supply assembly providing vaporized fuel to an engine wherein a quantity of liquid gasoline fuel is controllably heated for a desired vapor emission from the liquid fuel, and a conduit arrangement conducts the vapor, intermixes it with ambient air and conveys the intermixture to the engine's combustion chamber. A sensor in the engine exhaust monitors the hydrocarbon content of the exhaust and control valving controls the vapor to air intermixture in response to the monitor for maintaining a desired intermixture that produces the desired hydrocarbon content.

    摘要翻译： 燃料供应组件向发动机提供汽化燃料，其中一定数量的液体汽油燃料被可控地加热以便从液体燃料中发出所需的蒸汽，导管装置导入蒸气，将其与环境空气混合并将混合物输送到发动机 燃烧室。 发动机排气中的传感器监测排气的烃含量，并且响应于监测器控制阀控制蒸气与空气的混合，以保持产生期望的烃含量的期望的混合物。

    Vapor fueled engine
    3.
    发明申请
    Vapor fueled engine 失效
    汽油发动机

    公开(公告)号：US20070062503A1

    公开(公告)日：2007-03-22

    申请号：US10578693

    申请日：2004-05-07

    申请人： Raymond Bushnell ,  Danny Lewis ,  Robert Parry

    发明人： Raymond Bushnell ,  Danny Lewis ,  Robert Parry

    IPC分类号： F02D41/14 ,  F02G5/00

    CPC分类号： F02M31/183 ,  F02D41/003 ,  F02M17/20 ,  Y02T10/126

    摘要： A fuel supply assembly is provided that may allow for use of vaporized fuel to power an engine and enhance fuel efficiency. The fuel supply assembly may include a vaporizing tank, a heating source, a temperature control and a monitoring and control system configured to control intermixing of ambient air and vaporized gasoline to maintain a desired hydrocarbon level in an exhaust.

    摘要翻译： 提供燃料供应组件，其可以允许使用蒸发的燃料来为发动机提供动力并提高燃料效率。 燃料供应组件可以包括蒸发箱，加热源，温度控制和监控和控制系统，其被配置为控制环境空气和汽化汽油的混合以保持排气中所需的烃水平。

    VAPOR FUELED ENGINE
    4.
    发明申请
    VAPOR FUELED ENGINE 失效
    蒸汽发动机

    公开(公告)号：US20050098161A1

    公开(公告)日：2005-05-12

    申请号：US10706507

    申请日：2003-11-11

    申请人： Raymond Bushnell ,  Danny Lewis ,  Robert Parry

    发明人： Raymond Bushnell ,  Danny Lewis ,  Robert Parry

    IPC分类号： F02D41/00 ,  F02M17/20 ,  F02M31/18

    CPC分类号： F02M31/183 ,  F02D41/003 ,  F02M17/20 ,  Y02T10/126

    摘要： A fuel supply assembly is provided that may allow for use of vaporized fuel to power an engine and enhance fuel efficiency. The fuel supply assembly may include a vaporizing tank, a heating source, a temperature control and a monitoring and control system configured to control intermixing of ambient air and vaporized gasoline to maintain a desired hydrocarbon level in an exhaust.

    摘要翻译： 提供燃料供应组件，其可以允许使用蒸发的燃料来为发动机提供动力并提高燃料效率。 燃料供应组件可以包括蒸发箱，加热源，温度控制和监控和控制系统，其被配置为控制环境空气和汽化汽油的混合以保持排气中所需的烃水平。

    METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF BIOACTIVE MOLECULES
    5.
    发明申请
    METHODS AND COMPOSITIONS FOR ENHANCED DELIVERY OF BIOACTIVE MOLECULES 审中-公开
    用于增强生物活性分子的方法和组合物

    公开(公告)号：US20080292712A1

    公开(公告)日：2008-11-27

    申请号：US12186203

    申请日：2008-08-05

    申请人： Danny Lewis ,  Paul Schmidt ,  Kenneth Hinds

    发明人： Danny Lewis ,  Paul Schmidt ,  Kenneth Hinds

    IPC分类号： A61K9/52 ,  A61K38/21 ,  A61K38/02 ,  A61K38/08 ,  A61K38/31 ,  A61P43/00

    CPC分类号： A61K47/6927 ,  A61K47/593 ,  A61K47/60 ,  A61K47/61

    摘要： Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly (lactic acid) (PLA), poly (glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.

    摘要翻译： 已经开发了用于受控的，延长释放生物活性分子例如治疗性蛋白质，肽和寡核苷酸的制剂。 这些制剂基于由可生物降解的合成聚合物如聚（乳酸）（PLA），聚（乙醇酸）（PGA）及其共聚物的组合形成的固体微粒或纳米颗粒。 将生物活性分子偶联到亲水性聚合物如聚乙二醇或聚丙二醇上，并配制成提供受控释放。 相对于缺乏偶联亲水聚合物的相同生物活性分子，生物活性分子更稳定，免疫原性更小，具有更低的爆发水平和更高的药物负载量的改善的释放速率分布。 控制释放制剂可以通过注射，吸入，鼻腔或口服给药。

    Methods and compositions for enhanced delivery of bioactive molecules
    6.
    发明授权
    Methods and compositions for enhanced delivery of bioactive molecules 有权
    用于增强生物活性分子递送的方法和组合物

    公开(公告)号：US06706289B2

    公开(公告)日：2004-03-16

    申请号：US09999820

    申请日：2001-10-31

    申请人： Danny Lewis ,  Paul Schmidt ,  Kenneth Hinds

    发明人： Danny Lewis ,  Paul Schmidt ,  Kenneth Hinds

    IPC分类号： A61F202

    CPC分类号： A61K47/6927 ,  A61K47/593 ,  A61K47/60 ,  A61K47/61

    摘要： Formulations for controlled, prolonged release of bioactive molecules such as therapeutic proteins, peptides and oligonucleotides have been developed. These formulations are based on solid microparticles or nanoparticles formed of the combination of biodegradable, synthetic polymers such as poly(lactic acid) (PLA), poly(glycolic acid) (PGA), and copolymers thereof. Bioactive molecules are coupled to hydrophilic polymers such as polyethylene glycol or polypropylene glycol and formulated to provide controlled release. The bioactive molecules are more stable, less immunogenic and have improved release rate profiles with lower burst levels and increased drug loading relative to the same bioactive molecules lacking coupled hydrophilic polymers. The controlled release formulations can be administered by injection, by inhalation, nasally, or orally.

    摘要翻译： 已经开发了用于受控的，延长释放生物活性分子例如治疗性蛋白质，肽和寡核苷酸的制剂。 这些制剂基于由可生物降解的合成聚合物如聚（乳酸）（PLA），聚（乙醇酸）（PGA）及其共聚物的组合形成的固体微粒或纳米颗粒。 将生物活性分子偶联到亲水性聚合物如聚乙二醇或聚丙二醇上，并配制成提供受控释放。 相对于缺乏偶联亲水聚合物的相同生物活性分子，生物活性分子更稳定，免疫原性更小，具有更低的爆发水平和更高的药物负载量的改善的释放速率分布。 控制释放制剂可以通过注射，吸入，鼻腔或口服给药。

    Materials and methods for preparing protein-polymer conjugates
    7.
    发明授权
    Materials and methods for preparing protein-polymer conjugates 有权
    制备蛋白质 - 聚合物共轭物的材料和方法

    公开(公告)号：US09040664B2

    公开(公告)日：2015-05-26

    申请号：US10553570

    申请日：2004-04-08

    申请人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen M. Campbell

    发明人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen M. Campbell

    IPC分类号： A61K38/00 ,  C07K14/62 ,  A61K47/48 ,  A61K9/50 ,  A61K38/28

    CPC分类号： A61K47/60 ,  A61K9/5031 ,  A61K38/28 ,  C07K14/62

    摘要： The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

    摘要翻译： 本发明涉及用于快速且有效地制备包括胰岛素 - 聚合物缀合物的蛋白质 - 聚合物缀合物的单步方法。 根据本发明的方法，蛋白质和亲水性聚合物在至少一种有机溶剂和至少一种金属螯合剂的存在下，在促进蛋白质和聚合物的缀合物形成的条件下接触。 因此，本发明涉及在残基PheB1上的聚（乙二醇）选择的蛋白质如胰岛素的位点特异性修饰。 本发明还提供了用于将缀合物包封在可生物降解的聚合物中的药物制剂。

    Method for preparation of site-specific protein conjugates
    9.
    发明申请
    Method for preparation of site-specific protein conjugates 有权
    制备位点特异性蛋白质共轭物的方法

    公开(公告)号：US20070083006A1

    公开(公告)日：2007-04-12

    申请号：US10553570

    申请日：2004-04-08

    申请人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen Campell

    发明人： Kenneth Hinds ,  Danny Lewis ,  Paul Schmidt ,  Kathleen Campell

    IPC分类号： C07K14/00 ,  C07K14/62

    CPC分类号： A61K47/60 ,  A61K9/5031 ,  A61K38/28 ,  C07K14/62

    摘要： The invention is directed to a single-step method for rapidly and efficiently preparing protein-polymer conjugates, including an insulin-polymer conjugate. According to the method of the present invention, a protein and hydrophilic polymer are contacted in the presence of at least one organic solvent and at least one metal chelator, under conditions that promote the formation of a conjugate of the protein and polymer. Thus, the invention is directed to the site-specific modification of selected proteins, such as insulin, with poly(ethylene glycol) at residue PheB 1. The invention also provides a pharmaceutical formulation for encapsulating the conjugate in a biodegradable polymer.

    摘要翻译： 本发明涉及用于快速且有效地制备包括胰岛素 - 聚合物缀合物的蛋白质 - 聚合物缀合物的单步方法。 根据本发明的方法，蛋白质和亲水性聚合物在至少一种有机溶剂和至少一种金属螯合剂的存在下，在促进蛋白质和聚合物的缀合物形成的条件下接触。 因此，本发明涉及在残基PheB 1上与聚（乙二醇）一起选择的蛋白质（例如胰岛素）的位点特异性修饰。本发明还提供用于将缀合物包封在可生物降解的聚合物中的药物制剂。