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公开(公告)号：US20190309087A1
公开(公告)日：2019-10-10
申请号：US16316629
申请日：2017-07-18
发明人： Ranit KEDMI , Nuphar VEIGA , Itai BENHAR , Dan PEER
摘要： A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.
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公开(公告)号：US20230312745A1
公开(公告)日：2023-10-05
申请号：US18206645
申请日：2023-06-07
发明人： Ranit KEDMI , Nuphar VEIGA , Itai BENHAR , Dan PEER
CPC分类号： C07K16/30 , A61K9/127 , A61K47/543 , A61P35/00 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2845 , C07K16/2866 , C07K16/2896 , C07K16/4241 , C12N15/11 , C12N15/111 , C12N2320/32
摘要： A lipidated secondary antibody is disclosed. Particles comprising same are also disclosed.
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公开(公告)号：US20180000990A1
公开(公告)日：2018-01-04
申请号：US15702834
申请日：2017-09-13
发明人： Tal DVIR , Dan PEER , Michal SHEVACH , Neta SOFFER TSUR
IPC分类号： A61L27/36 , A61K35/34 , C12N5/077 , A61L27/14 , A61K35/44 , A61L27/58 , A61L27/52 , A61L27/38 , C12N5/074 , C12N5/071
CPC分类号： A61L27/3633 , A61K35/34 , A61K35/44 , A61L27/14 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/3826 , A61L27/3834 , A61L27/52 , A61L27/58 , A61L2430/20 , A61L2430/40 , C12N5/0657 , C12N5/0691 , C12N5/0696
摘要： Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
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公开(公告)号：US20240246898A1
公开(公告)日：2024-07-25
申请号：US18489240
申请日：2023-10-18
发明人： Dan PEER , Srinivas RAMISHETTI
IPC分类号： C07C211/22 , A61K47/18 , A61K48/00 , A61P29/00 , A61P35/00 , C07C59/01 , C07C215/08 , C07C219/04 , C07C229/02 , C07C229/10 , C07C229/12 , C07C233/00 , C07C243/00 , C07C243/10 , C07C243/14 , C07C243/16 , C07C243/26 , C07C243/28 , C07C279/04 , C07C333/10 , C07D233/64 , C07D295/13 , C07D295/15 , C12N15/113
CPC分类号： C07C211/22 , A61K47/18 , A61K48/00 , A61P29/00 , A61P35/00 , C07C59/01 , C07C215/08 , C07C219/04 , C07C229/02 , C07C229/10 , C07C229/12 , C07C233/00 , C07C243/00 , C07C243/10 , C07C243/14 , C07C243/16 , C07C243/26 , C07C243/28 , C07C279/04 , C07C333/10 , C07D233/64 , C07D295/13 , C07D295/15 , C12N15/113 , C12N2310/14
摘要： The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
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公开(公告)号：US20230201127A1
公开(公告)日：2023-06-29
申请号：US17988824
申请日：2022-11-17
发明人： Dan PEER , Daniel ROSENBLUM , Anna GUTKIN
IPC分类号： A61K9/51 , A61K38/46 , A61K31/7088 , A61P35/00
CPC分类号： A61K9/5123 , A61K38/465 , A61K31/7088 , A61P35/00
摘要： Lipid particles for nucleic acid delivery and clinical applications of same are provided. Accordingly there is provided a lipid particle comprising a cationic lipid encapsulating a nucleic acid sequence, wherein said nucleic acid sequence encodes a protein having a length of at least 500 amino acids, the cationic lipid being represented by Formula I, as defined in the specification.
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公开(公告)号：US20160354318A1
公开(公告)日：2016-12-08
申请号：US15228449
申请日：2016-08-04
发明人： Rimona MARGALIT , Dan PEER
IPC分类号： A61K9/50 , A61K51/12 , A61K51/08 , A61K48/00 , A61K31/14 , A61K38/38 , A61K31/407 , A61K47/48 , A61K38/21 , A61K31/7088 , A61K38/28 , A61K49/00 , A61K31/351
CPC分类号： A61K9/5052 , A61K9/1629 , A61K9/1658 , A61K9/5089 , A61K31/14 , A61K31/165 , A61K31/196 , A61K31/351 , A61K31/407 , A61K31/704 , A61K31/7088 , A61K31/711 , A61K38/212 , A61K38/28 , A61K38/385 , A61K45/06 , A61K47/545 , A61K48/0008 , A61K49/0002 , A61K49/0043 , A61K51/08 , A61K51/1265
摘要： Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.
摘要翻译： 通过将糖蛋白（通常为胶原）与至少一种脂质共价连接来制备脂质化的微粒或大颗粒。 糖蛋白中的氨基与脂质中的伯胺结合。 这些颗粒可用于包封活性成分，如药物。
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公开(公告)号：US20240166593A1
公开(公告)日：2024-05-23
申请号：US18263795
申请日：2022-02-02
发明人： Srinivas RAMISHETTI , Dan PEER
IPC分类号： C07C239/22 , A61K9/127 , C07C229/12 , C07C229/16 , C07C233/36 , C07D295/15 , C12N15/88
CPC分类号： C07C239/22 , A61K9/1272 , C07C229/12 , C07C229/16 , C07C233/36 , C07D295/15 , C12N15/88
摘要： The present invention provides lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their intracellular delivery both in vitro and for therapeutic applications. The present invention also provides methods of chemical synthesis of these lipids, lipid nanoparticle preparation and formulation with nucleic acids.
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公开(公告)号：US20170143641A1
公开(公告)日：2017-05-25
申请号：US15402444
申请日：2017-01-10
发明人： Dan PEER
IPC分类号： A61K9/51 , C12N15/113
CPC分类号： A61K9/5161 , A61K9/1272 , A61K9/5123 , A61K47/6849 , A61K47/6935 , A61K47/6939 , B82Y5/00 , C12N15/113 , C12N15/87 , C12N15/88 , C12N2310/14 , C12N2310/141 , Y10T428/2982 , Y10T428/2991
摘要： A method of generating a particle is disclosed, the particle being for delivery of a polynucleotide to a target cell. The method comprises (a) contacting the polynucleotide with a composition comprising cationic molecules, wherein the cationic molecules condense the polynucleotide by electrostatic interactions to generate a complex, wherein the cationic molecules are not comprised in a liposome; and (b) covalently binding the complex to a targeting moiety at a pH equal to or below about 4.5, thereby generating the particle for delivery of the polynucleotide agent to the target cell. Use of the particles and compositions comprising same are also disclosed.
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公开(公告)号：US20150366979A1
公开(公告)日：2015-12-24
申请号：US14765790
申请日：2014-02-05
发明人： Joseph KOST , Riki GOLDBART , Tamar TRAITEL , Eliz LEWIS AMAR , Rinat LIFSHIZ , Dan PEER
IPC分类号： A61K47/48 , C12N15/113 , A61K41/00
CPC分类号： A61K47/4823 , A61K9/5161 , A61K41/0047 , A61K47/61 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2320/32
摘要： A complex includes RNA and a positively charged modified polysaccharide selected from starch, amylose, amylopectin, galactan, chitosan, or dextrin. The complex can be formed into a pharmaceutical composition. The complex can be used in methods for RNA transfection, gene therapy and treatment of a disease, disorder or condition. The positively charged modified polysaccharide can be used in connection with RNA transfection into cells.
摘要翻译： 复合物包括RNA和选自淀粉，直链淀粉，支链淀粉，半乳聚糖，壳聚糖或糊精的带正电荷的改性多糖。 络合物可以形成药物组合物。 该复合物可用于RNA转染，基因治疗和疾病，病症或病症治疗的方法。 带正电的改性多糖可以与RNA转染细胞结合使用。
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公开(公告)号：US20150202348A1
公开(公告)日：2015-07-23
申请号：US14581540
申请日：2014-12-23
发明人： Tal DVIR , Dan PEER , Michal SHEVACH , Neta SOFFER TSUR
IPC分类号： A61L27/36 , A61K35/34 , A61K35/44 , A61L27/38 , C12N5/071 , C12N5/074 , C12N5/077 , A61L27/52
CPC分类号： A61L27/3633 , A61K35/34 , A61K35/44 , A61L27/14 , A61L27/3604 , A61L27/3687 , A61L27/3804 , A61L27/3826 , A61L27/3834 , A61L27/52 , A61L27/58 , A61L2430/20 , A61L2430/40 , C12N5/0657 , C12N5/0691 , C12N5/0696
摘要： Compositions of matter comprising decellularized omentum are disclosed. The compositions may be scaffolds, hydrogels or hydrogel precursor compositions. Methods of generating the compositions are disclosed as well as uses thereof.
摘要翻译： 公开了包含脱细胞网膜的物质组合物。 组合物可以是支架，水凝胶或水凝胶前体组合物。 公开了生成组合物的方法及其用途。
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