公开(公告)号：US20230201127A1

公开(公告)日：2023-06-29

申请号：US17988824

申请日：2022-11-17

申请人： Ramot at Tel-Aviv University Ltd.

发明人： Dan PEER ,  Daniel ROSENBLUM ,  Anna GUTKIN

IPC分类号： A61K9/51 ,  A61K38/46 ,  A61K31/7088 ,  A61P35/00

CPC分类号： A61K9/5123 ,  A61K38/465 ,  A61K31/7088 ,  A61P35/00

摘要： Lipid particles for nucleic acid delivery and clinical applications of same are provided. Accordingly there is provided a lipid particle comprising a cationic lipid encapsulating a nucleic acid sequence, wherein said nucleic acid sequence encodes a protein having a length of at least 500 amino acids, the cationic lipid being represented by Formula I, as defined in the specification.