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    Non-human animal model for systemic lupus erythematosis
    1.
    发明授权
    Non-human animal model for systemic lupus erythematosis 失效
    用于系统性红斑狼疮的非人类动物模型

    公开(公告)号：US06232522B1

    公开(公告)日：2001-05-15

    申请号：US08160604

    申请日：1993-11-30

    申请人： John B. Harley ,  Judith A. James ,  R. Hal Scofield

    发明人： John B. Harley ,  Judith A. James ,  R. Hal Scofield

    IPC分类号： C07K500

    CPC分类号： C07K14/4713 ,  A01K2267/0325 ,  A61K38/00 ,  A61K39/00 ,  C07K14/005 ,  C12N2760/20222 ,  G01N33/564 ,  G01N33/56983 ,  G01N33/6878 ,  G01N2800/104 ,  G01N2800/24 ,  Y02A50/403

    摘要： A specific method has been developed to produce an autoimmune response and resulting clinical symptoms for a particular disease process. Peptides or other structures derived from an autoantigen and which are bound by auto antibody or T cell receptors are identified and used to induce an immune response. This immune response evolves into an autoimmune response directed against the other portions of the protein from which the peptide was derived. Subsequently, clinical manifestations may appear that are also found in the clinical illness. selected from the group including viruses, bacteria, fungi, parasites, rickettsia, plasmids, and insects which contains a structure or a peptide sequence that is similar to a structure or peptide sequence that has been identified by the method of claim 1 to the extent that it is bound by one of the group selected from antigen specific B cell surface receptors, and antigen specific T cell receptors.

    摘要翻译： 已经开发了一种特定的方法来产生针对特定疾病过程的自身免疫反应和产生的临床症状。 鉴定出衍生自自身抗原并且被自身抗体或T细胞受体结合的肽或其它结构并用于诱导免疫应答。 这种免疫应答演变成针对来自肽的蛋白质的其它部分的自身免疫应答。 随后，临床表现也可能出现在临床疾病中。 选自包含病毒，细菌，真菌，寄生虫，立克次体，质粒和昆虫的组，其包含与通过权利要求1的方法鉴定的结构或肽序列类似的结构或肽序列， 它被选自抗原特异性B细胞表面受体和抗原特异性T细胞受体中的一个组结合。

    Peptide diagnostics and therapeutics for spondyloarthropathies
    2.
    发明授权
    Peptide diagnostics and therapeutics for spondyloarthropathies 失效
    脊柱关节病的肽诊断和治疗

    公开(公告)号：US5719064A

    公开(公告)日：1998-02-17

    申请号：US944143

    申请日：1992-08-31

    申请人： R. Hal Scofield ,  John B. Harley

    发明人： R. Hal Scofield ,  John B. Harley

    IPC分类号： A61K38/00 ,  C07K14/195 ,  C07K14/74 ,  G01N33/543

    CPC分类号： C07K14/195 ,  C07K14/70539 ,  A61K38/00

    摘要： It has been determined that HLA B27 is related to proteins of the Gram negative enteric bacteria. The hypervariable regions of the HLA B alleles were compared to the known sequenced proteins for short consecutive amino acid identities. It was found that, unique to the HLA B alleles,, HLA B27 shares an unexpected number of hexapeptides and pentapeptides with Gram negative bacteria proteins. The proteins from enteric organisms that share sequence with B27 tend to have sequences that satisfy protein sequence motifs which are thought to predict binding to B27. In addition, there is a sequence in B27, LRRYLENGK, which is predicted to bind as a peptide to B27. Binding of this peptide to B27 has been demonstrated. The disclosed peptides are useful for diagnostic and therapeutic purposes and can be used to design additional peptides from Gram negative enteric organisms can be identified to be important in the spondyloarthropathies. These peptides and their analogs can be used to screen for antibodies, and more importantly, T cells reactive with the peptides, which are indicative of the spondyloarthropathies.

    摘要翻译： 已经确定HLA B27与革兰氏阴性肠细菌的蛋白质相关。 将HLA B等位基因的高变区与已知测序的蛋白质进行比较以获得短的连续氨基酸同一性。 已经发现，HLA B等位基因特有的HLA B27与革兰氏阴性细菌蛋白质共享了意想不到的数量的六肽和五肽。 来自与B27共享序列的肠道生物体的蛋白质倾向于具有满足蛋白质序列基序的序列，这些序列被认为预测与B27的结合。 此外，B27中有一个序列，LRRYLENGK被预测作为肽结合到B27上。 已证明该肽与B27的结合。 所公开的肽可用于诊断和治疗目的，并且可用于设计来自革兰氏阴性肠道生物体的附加肽可以在脊椎关节病中被鉴定为重要的。 这些肽及其类似物可用于筛选抗体，更重要的是，与肽反应的T细胞，其指示脊柱关节病。