公开(公告)号：US10342821B2

公开(公告)日：2019-07-09

申请号：US15702091

申请日：2017-09-12

申请人： PROTERRIS, INC.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61K33/04 ,  A61K33/00 ,  G01N33/72 ,  A61M16/00 ,  A61M16/10 ,  A61M16/12

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

公开(公告)号：US20190321394A1

公开(公告)日：2019-10-24

申请号：US16458838

申请日：2019-07-01

申请人： Proterris Inc.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61K33/00 ,  A61M16/00 ,  G01N33/72 ,  A61M16/10 ,  A61M16/12

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

公开(公告)号：US20160256485A1

公开(公告)日：2016-09-08

申请号：US15035796

申请日：2014-11-14

申请人： PROTERRIS, INC.

发明人： Jeffrey Wager ,  Joseph Wager ,  Alex Stenzler

IPC分类号： A61K33/00 ,  C12Q1/37

CPC分类号： A61K33/00 ,  C12Q1/37 ,  G01N2333/96486

摘要： A method of treating a patient having a lung condition that includes identifying a target haemoglobin-carbon monoxide level in the blood of the patient. The method also includes administering, to the patient, carbon monoxide at a first concentration for an initial time period, and measuring the haemoglobin-carbon monoxide level in the blood of the patient. The method also includes calculating, based on the measured haemoglobin-carbon monoxide level and the target haemoglobin-carbon monoxide level, a dose of carbon monoxide required to attain the target haemoglobin-carbon monoxide level within a determined time period. The method also includes administering, to the patient, the calculated dose of carbon monoxide for the determined time period to attain the target haemoglobin-carbon monoxide level in the blood of the patient.

摘要翻译： 一种治疗患有肺部病症的患者的方法，其包括鉴定患者血液中的目标血红蛋白一氧化碳水平。 该方法还包括以初始时间段的第一浓度向患者施用一氧化碳，以及测量患者血液中的血红蛋白 - 一氧化碳水平。 该方法还包括基于测量的血红蛋白 - 一氧化碳水平和目标血红蛋白 - 一氧化碳水平计算在确定的时间段内达到目标血红蛋白 - 一氧化碳水平所需的一氧化碳剂量。 该方法还包括在确定的时间内向患者施用计算的一氧化碳剂量以获得患者血液中的目标血红蛋白 - 一氧化碳水平。

公开(公告)号：US20150320791A1

公开(公告)日：2015-11-12

申请号：US14687740

申请日：2015-04-15

申请人： Proterris Inc.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61K33/00 ,  A61M16/10 ,  A61M16/12 ,  G01N33/72 ,  A61M16/00

CPC分类号： A61K33/00 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/10 ,  A61M16/12 ,  A61M2016/1035 ,  A61M2202/0208 ,  A61M2202/0233 ,  G01N33/721 ,  G01N2333/805 ,  G01N2800/52 ,  A61M2202/0007

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

摘要翻译： 本发明提供了用于吸入CO治疗的系统和方法，以预防，减弱或延迟加速器官或组织功能丧失的过程，从而增加移植的器官或组织的寿命，或减缓天然器官或组织的下降， 或延迟用器官移植替代患病的天然器官的需要。 预防，减毒或延迟的这种生物过程包括慢性持续性炎症，纤维化，瘢痕形成，以及免疫或自身免疫性攻击。

公开(公告)号：US20210308175A1

公开(公告)日：2021-10-07

申请号：US17349425

申请日：2021-06-16

申请人： Proterris Inc.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61K33/00 ,  G01N33/72 ,  A61M16/00 ,  A61M16/10 ,  A61M16/12

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

公开(公告)号：US20190022132A1

公开(公告)日：2019-01-24

申请号：US16142883

申请日：2018-09-26

申请人： PROTERRIS, INC.

发明人： Jeffrey Wager ,  Joseph Wager ,  Alex Stenzler

IPC分类号： A61K33/00 ,  C12Q1/37

摘要： A method of treating a patient having a lung condition that includes identifying a target haemoglobin-carbon monoxide level in the blood of the patient. The method also includes administering, to the patient, carbon monoxide at a first concentration for an initial time period, and measuring the haemoglobin-carbon monoxide level in the blood of the patient. The method also includes calculating, based on the measured haemoglobin-carbon monoxide level and the target haemoglobin-carbon monoxide level, a dose of carbon monoxide required to attain the target haemoglobin-carbon monoxide level within a determined time period. The method also includes administering, to the patient, the calculated dose of carbon monoxide for the determined time period to attain the target haemoglobin-carbon monoxide level in the blood of the patient.

公开(公告)号：US20180000859A1

公开(公告)日：2018-01-04

申请号：US15702091

申请日：2017-09-12

申请人： PROTERRIS, INC.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61K33/00 ,  A61M16/00 ,  G01N33/72 ,  A61M16/10 ,  A61M16/12

CPC分类号： A61K33/00 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/10 ,  A61M16/12 ,  A61M2016/1035 ,  A61M2202/0208 ,  A61M2202/0233 ,  G01N33/721 ,  G01N2333/805 ,  G01N2800/52 ,  A61M2202/0007

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

公开(公告)号：US09789133B2

公开(公告)日：2017-10-17

申请号：US14687740

申请日：2015-04-15

申请人： Proterris Inc.

发明人： Jeffrey D. Wager ,  Joseph Wager ,  Alex Stenzler ,  David Pinsky ,  Augustine Choi

IPC分类号： A61M16/12 ,  A61M16/10 ,  A61K33/00 ,  G01N33/72 ,  A61M16/00

CPC分类号： A61K33/00 ,  A61M16/0051 ,  A61M16/026 ,  A61M16/10 ,  A61M16/12 ,  A61M2016/1035 ,  A61M2202/0208 ,  A61M2202/0233 ,  G01N33/721 ,  G01N2333/805 ,  G01N2800/52 ,  A61M2202/0007

摘要： The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.