-
公开(公告)号：US20040209249A1
公开(公告)日：2004-10-21
申请号：US09878423
申请日：2001-06-11
Applicant: Prokaria Ltd.
Inventor： Arnthor Aevarsson , Viggo T. Marteinsson , Gudmundur O. Hreggvidsson , Jakob K. Kristjansson , Olafur H. Fridjonsson
IPC: C12Q001/68
CPC classification number: G01N33/6803 , C07K1/306 , C07K2299/00 , C12N15/1034
Abstract: The present invention provides a method that can facilitate structure determination of target proteins by x-ray crystallography. It is a method of rational crystallization of members of a target protein family obtained through specific amplification of corresponding genes from natural diversity. The method makes broad biodiversity accessible through sampling and ecological enrichment of diverse high-temperature ecosystems containing thermophilic microorganisms including uncultivable and previously unknown organisms. The method provides means to circumvent many potential problems and bottlenecks in crystal structure determination by selection of suitable proteins directly from nature. The invention combines methods of accessing and screening vast natural diversity and the inherent suitability of thermostable proteins for crystallization in order to maximize probability of successful structure determination.
Abstract translation: 本发明提供了可以通过x射线晶体学方法促进靶蛋白质的结构测定的方法。 它是通过从天然多样性的相应基因的特异性扩增获得的靶蛋白家族成员的合理结晶的方法。 该方法通过采样和生态丰富多样性的生物多样性来获取广泛的生物多样性，包括含有嗜热微生物的多种高温生态系统，包括无法复原的和以前未知的 该方法提供了通过直接从大自然中选择合适的蛋白质来规避晶体结构测定中许多潜在问题和瓶颈的手段。 本发明结合了获取和筛选广泛的自然多样性的方法以及热稳定蛋白质固有的结晶适应性，以便最大化结构测定的可能性。
-
2.发明申请公开(公告)号：US20030092134A1
公开(公告)日：2003-05-15
申请号：US10270859
申请日：2002-10-11
Applicant: Prokaria ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C12Q001/68 , C12P021/06 , C12P019/34 , A61K039/12
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
公开(公告)号：US20030082790A1
公开(公告)日：2003-05-01
申请号：US10270878
申请日：2002-10-11
Applicant: Prokaria ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C07H021/04 , C12N007/00 , C12N007/01 , C07K001/00 , C07K014/00 , C07K017/00
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
Patent Agency Ranking
公开(公告)号：US20030082741A1
公开(公告)日：2003-05-01
申请号：US10270875
申请日：2002-10-11
Applicant: Prokaria Ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C12P021/02 , C12N001/21 , C12N005/06 , C07H021/04 , C12N009/22 , C12N007/00 , C12N015/86
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
公开(公告)号：US20040058330A1
公开(公告)日：2004-03-25
申请号：US10251667
申请日：2002-09-20
Applicant: Prokaria, ltd.
Inventor： Arnthor Aevarsson , Thorarinn Blondal , Olafur H. Fridjonsson , Sigurlaug Skirnisdottir , Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Jakob K. Kristjansson
IPC: C12Q001/68 , C12P019/34
CPC classification number: C12N15/1093 , C12P19/34 , C12Q2521/501
Abstract: The activity and functional properties of novel thermostable RNA ligases isolated from thermophilic bacteriophages are described. Also described are methods of using these thermostable RNA ligases for various applications including nucleotide labeling, oligonucleotide synthesis, gene synthesis, gene amplification and amplification of mRNA and synthesis of cDNA.
Abstract translation: 描述了从嗜热噬菌体分离的新型耐热RNA连接酶的活性和功能特性。 还描述了使用这些耐热RNA连接酶用于各种应用的方法，包括核苷酸标记，寡核苷酸合成，基因合成，mRNA的基因扩增和扩增以及cDNA的合成。
-
6.发明申请公开(公告)号：US20030129727A1
公开(公告)日：2003-07-10
申请号：US10270846
申请日：2002-10-11
Applicant: Prokaria ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C12Q001/68 , C12P021/06 , C12P019/34 , C12N007/00 , C12N007/01
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
公开(公告)号：US20030092128A1
公开(公告)日：2003-05-15
申请号：US10270710
申请日：2002-10-11
Applicant: Prokaria ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C12P021/02 , C12N005/06 , C12N001/21 , C07H021/04 , C12N007/00 , C12N015/86 , C12N015/09 , C12N009/50 , C12N007/01 , C12N001/20 , C12N005/00 , C12N005/02 , C07K001/00 , C07K014/00 , C07K017/00
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
公开(公告)号：US20030087392A1
公开(公告)日：2003-05-08
申请号：US10270786
申请日：2002-10-11
Applicant: Prokaria Ltd.
Inventor： Sigridur Hjorleifsdottir , Gudmundur O. Hreggvidsson , Olafur H. Fridjonsson , Arnthor Aevarsson , Jakob K. Kristjansson
IPC: C12P021/02 , C12N001/21 , C12N005/06 , C07H021/04 , C12N009/22 , C12N007/00 , C12N015/86 , C12N015/09 , C12N007/01 , C12N001/20 , C12N005/00 , C12N005/02
CPC classification number: C07K14/005 , C12N7/00 , C12N2795/10121 , C12N2795/10122 , Y10T436/143333
Abstract: A novel bacteriophage RM 378 of Rhodothermus marinus, the nucleic acids of its genome, nucleic acids comprising nucleotide sequences of open reading frames (ORFs) of its genome, and polypeptides encoded by the nucleic acids, are described.
Abstract translation: 描述了Rhodothermus marinus的新型噬菌体RM378，其基因组的核酸，其包含其基因组的开放阅读框（ORF）的核苷酸序列的核酸和由核酸编码的多肽。
-
-
-
-
-
-
-
Search Results
8
records
(took 0.019 seconds)
