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    Specific delivery of agrochemicals
    5.
    发明授权
    Specific delivery of agrochemicals 有权
    具体交付农药

    公开(公告)号：US08598081B2

    公开(公告)日：2013-12-03

    申请号：US13081435

    申请日：2011-04-06

    申请人： Erik Jongedijk ,  Peter Verheesen

    发明人： Erik Jongedijk ,  Peter Verheesen

    IPC分类号： A01N25/00 ,  C07K16/16

    CPC分类号： A01N25/28 ,  A01N25/00 ,  A61K47/48507 ,  A61K47/6835 ,  C07K16/16 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/92 ,  A01N25/24 ,  A01N53/00

    摘要： Described is the specific delivery of agrochemicals to plants. More specifically, a targeting agent has at least one binding domain that specifically binds to a binding site on an intact living plant. Such binding domains include a peptide having 4 framework regions and 3 complementarity-determining regions, or fragment thereof, wherein the binding domains bind or retain a carrier onto a plant. Described are binding domains that specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. Further described is a method for delivering agrochemicals to a plant, for depositing agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to a method for protecting a plant against stress or controlling plant growth. Also, described is a method for manufacturing a specifically targeting agrochemical carrier.

    摘要翻译： 描述了农药对植物的具体交付。 更具体地，靶向剂具有至少一个特异性结合完整活植物上的结合位点的结合结构域。 这样的结合结构域包括具有4个构架区和3个互补决定区或其片段的肽，其中结合域将载体结合或保留在植物上。 描述了特异性结合毛状体，气孔，角质层，微孔，刺，刺，根毛或蜡层的结合域。 还描述了一种用于将农业化学品递送到植物的方法，用于在植物上沉积农业化学品，以及使用包含结合域的靶向剂将植物上的农药残留在植物上，以及用于保护植物免受胁迫或控制植物生长的方法 。 此外，描述了一种用于制造特异性靶向的农药载体的方法。

    SPECIFIC DELIVERY OF AGROCHEMICALS
    6.
    发明申请
    SPECIFIC DELIVERY OF AGROCHEMICALS 审中-公开
    农业特定交付

    公开(公告)号：US20140128579A1

    公开(公告)日：2014-05-08

    申请号：US14017637

    申请日：2013-09-04

    申请人： Erik Jongedijk ,  Peter Verheesen

    发明人： Erik Jongedijk ,  Peter Verheesen

    IPC分类号： C07K16/16

    CPC分类号： A01N25/28 ,  A01N3/00 ,  A01N25/00 ,  A01N25/24 ,  A61K47/6835 ,  C07K16/16 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/92 ,  A01N53/00

    摘要： Described is the specific delivery of agrochemicals to plants. More specifically, a targeting agent has at least one binding domain that specifically binds to a binding site on an intact living plant. Such binding domains include a peptide having 4 framework regions and 3 complementary determining regions, or fragment(s) thereof, wherein the binding domains bind or retain a carrier onto a plant. Described are binding domains that specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. Further described are methods for delivering agrochemicals to a plant, for depositing agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to methods for protecting a plant against stress or controlling plant growth. Also, described are methods for manufacturing a specifically targeting agrochemical carrier.

    摘要翻译： 描述了农药对植物的具体交付。 更具体地，靶向剂具有至少一个特异性结合完整活植物上的结合位点的结合结构域。 这样的结合结构域包括具有4个构架区和3个互补决定区或其片段的肽，其中结合域将载体结合或保留在植物上。 描述了特异性结合毛状体，气孔，角质层，微孔，刺，刺，根毛或蜡层的结合域。 进一步描述的是将农业化学品递送到植物，用于在植物上沉积农业化学品以及使用包含结合结构域的靶向剂将植物上的农业化学品保留的方法以及用于保护植物免受胁迫或控制植物生长的方法。 还描述了制造特异性靶向农药载体的方法。

    INSECT BINDING ANTIBODIES
    7.
    发明申请
    INSECT BINDING ANTIBODIES 审中-公开
    INSECT BINDING抗体

    公开(公告)号：US20130224226A1

    公开(公告)日：2013-08-29

    申请号：US13819326

    申请日：2011-08-25

    申请人： Peter Verheesen ,  Erik Jongedijk

    发明人： Peter Verheesen ,  Erik Jongedijk

    IPC分类号： C07K16/18 ,  A01N37/44

    CPC分类号： C07K16/18 ,  A01N37/44 ,  A01N37/46 ,  A01N63/00 ,  C07K2317/22 ,  C07K2317/569

    摘要： Described is a binding domain, preferably an antigen binding domain, more preferably an antigen binding domain that specifically binds a binding site on an insect. More specifically, described are antigen binding domains comprising an amino acid sequence that comprises 4 framework regions and 3 complementary determining regions, whereby the antigen binding domains are capable to bind specifically to an insect as a whole, preferably to a binding site on the insect surface. Further described is the use of the binding domain to deliver a compound, preferably a biologically active agent to the insect, and to insecticidal compositions comprising the binding domain.

    摘要翻译： 描述了结合结构域，优选抗原结合结构域，更优选特异性结合昆虫上的结合位点的抗原结合结构域。 更具体地，描述了包含包含4个框架区和3个互补决定区的氨基酸序列的抗原结合结构域，由此抗原结合结构域能够特异性结合昆虫作为整体，优选结合昆虫表面上的结合位点 。 进一步描述的是使用结合结构域将化合物，优选生物活性剂递送到昆虫，以及包含结合结构域的杀虫组合物。

    SPECIFIC DELIVERY OF AGROCHEMICALS
    8.
    发明申请
    SPECIFIC DELIVERY OF AGROCHEMICALS 有权
    农业特定交付

    公开(公告)号：US20110244011A1

    公开(公告)日：2011-10-06

    申请号：US13081435

    申请日：2011-04-06

    申请人： Erik Jongedijk ,  Peter Verheesen

    发明人： Erik Jongedijk ,  Peter Verheesen

    IPC分类号： A01N53/08 ,  C07K16/16 ,  A01N37/44 ,  A01P7/04 ,  A01P5/00 ,  A01P3/00 ,  A01N25/12 ,  B82Y5/00

    CPC分类号： A01N25/28 ,  A01N25/00 ,  A61K47/48507 ,  A61K47/6835 ,  C07K16/16 ,  C07K2317/35 ,  C07K2317/569 ,  C07K2317/92 ,  A01N25/24 ,  A01N53/00

    摘要： The present invention relates to specific delivery of agrochemicals to plants. More specifically, it relates to a composition, essentially consisting of a targeting agent comprising at least one binding domain that specifically binds to a binding site on an intact living plant and an agrochemical or a combination of agrochemicals. The present invention relates further to a binding domain that specifically binds the binding site on an intact living plant. More specifically, it relates to binding domains comprising an amino acid sequence that comprises four framework regions and three complementary determining regions, or any suitable fragment thereof, whereby the binding domains are capable to bind or retain a carrier onto a plant. In one preferred embodiment, the invention relates to binding domains which specifically bind trichomes, stomata, cuticle, lenticels, thorns, spines, root hairs, or wax layer. The invention relates further to a method for delivery of agrochemicals to a plant, for improving the deposition of agrochemicals on a plant, and for retaining the agrochemicals on a plant, using targeting agents comprising the binding domains, and to a method for protecting a plant against biotic or abiotic stress or controlling plant growth using the same. Also, the invention relates to a method for manufacturing a specifically targeting agrochemical carrier.

    摘要翻译： 本发明涉及农药对植物的具体递送。 更具体地说，本发明涉及一种组合物，其基本上由包含至少一个结合结构域的靶向剂组成，所述结合结构域特异性结合完整活体植物上的结合位点，以及农业化学品或农用化学品的组合。 本发明还涉及特异性结合完整活的植物上的结合位点的结合结构域。 更具体地，本发明涉及包含包含四个框架区和三个互补决定区或其任何合适片段的氨基酸序列的结合结构域，由此结合结构域能够将载体结合或保留在植物上。 在一个优选的实施方案中，本发明涉及特异性结合毛状体，气孔，角质层，微孔，刺，刺，根毛或蜡层的结合结构域。 本发明进一步涉及一种用于将植物农药输送至植物的方法，用于改善农业化学品在植物上的沉积，以及使用包含结合结构域的靶向剂将植物上的农业化学品保留，以及保护植物的方法 针对生物或非生物胁迫或使用该胁迫控制植物生长。 此外，本发明涉及一种制造特异性靶向农药载体的方法。