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公开(公告)号：US20130203092A1
公开(公告)日：2013-08-08
申请号：US13388971
申请日：2012-02-03
IPC分类号： G01N21/64 , G01N33/566 , C07K14/42
CPC分类号： G01N33/6893 , C07K14/42 , G01N33/68 , G01N33/6842 , G01N2333/42 , G01N2400/00
摘要： The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.
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2.发明申请公开(公告)号：US20150198610A9
公开(公告)日：2015-07-16
申请号：US13388971
申请日：2012-02-03
IPC分类号： G01N33/68 , C07K14/42 , G01N33/566
CPC分类号： G01N33/6893 , C07K14/42 , G01N33/68 , G01N33/6842 , G01N2333/42 , G01N2400/00
摘要： The present invention provides methods, compositions, apparatus, and kits for assessing glycoforms of proteins as a biomarker for disease. A purified recombinant form of lectin is used as a detector molecule to specifically label target sugars expressed in disease states. The high affinity of recombinant lectin allows for automation of assays that would be used in the diagnosis of diseases such as, but not limited to, cancer or liver disease.
摘要翻译： 本发明提供了用于评估蛋白质糖蛋白作为疾病生物标志物的方法，组合物，装置和试剂盒。 使用纯化的重组形式的凝集素作为检测分子来特异性标记在疾病状态中表达的目标糖。 重组凝集素的高亲和力允许自动化将用于诊断疾病例如但不限于癌症或肝脏疾病的测定。
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公开(公告)号：US07816560B1
公开(公告)日：2010-10-19
申请号：US10031145
申请日：2000-08-10
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： C07C211/00 , C07C303/00 , C07C307/00 , C07C309/00
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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4.发明授权公开(公告)号：US07776550B2
公开(公告)日：2010-08-17
申请号：US11418598
申请日：2006-05-05
申请人： Timothy M. Block , Mary Ann Comunale , Anand Mehta
发明人： Timothy M. Block , Mary Ann Comunale , Anand Mehta
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N33/57438 , G01N2333/4728 , G01N2800/08 , G01N2800/085 , G01N2800/7028
摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.
摘要翻译： 公开了用于诊断怀疑患有这种病理学的受试者的肝脏病理学的方法。 所述方法包括定量检测生物流体中的蛋白质上的糖基化，更具体地岩藻糖基化，并将检测到的糖基化与在健康或疾病状态下这些蛋白质糖基化的参考值进行比较。
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5.发明授权Diagnosis of liver pathology through assessment of anti-gal IgG glycosylation 有权通过评估抗gal IgG糖基化来诊断肝脏病理学公开(公告)号：US09110078B2
公开(公告)日：2015-08-18
申请号：US12062715
申请日：2008-04-04
申请人： Timothy M. Block , Mary Ann Comunale , Anand Mehta
发明人： Timothy M. Block , Mary Ann Comunale , Anand Mehta
IPC分类号： G01N33/00 , G01N33/68 , G01N33/574
CPC分类号： G01N33/6854 , G01N33/57438 , G01N33/6842 , G01N2800/085 , G06F19/24
摘要： Methods for diagnosing pathology of the liver in subject suspected of having such pathology by measuring the glycosylation of anti-gal IgG in various biological fluids of the subject.
摘要翻译： 通过测量受试者的各种生物液体中抗-gal IgG的糖基化来诊断疑似患有这种病理学的对象的肝脏病理学的方法。
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公开(公告)号：US20100137365A1
公开(公告)日：2010-06-03
申请号：US12656370
申请日：2010-01-28
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W.J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/445 , A61P31/12 , A61P31/14 , C07D211/46 , C07D207/12 , C07C237/42 , A61K31/402 , A61K31/166
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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公开(公告)号：US10082512B2
公开(公告)日：2018-09-25
申请号：US11913348
申请日：2006-05-05
申请人： Timothy M. Block , Anand Mehta , Mary Ann Comunale
发明人： Timothy M. Block , Anand Mehta , Mary Ann Comunale
IPC分类号： G01N33/68 , G01N33/574 , G01N33/576
CPC分类号： G01N33/6893 , G01N33/57438 , G01N2333/4728 , G01N2800/08 , G01N2800/085 , G01N2800/7028
摘要： Methods for diagnosing pathology of the liver in a subject suspected of having such pathology are disclosed. The methods comprise quantifiably detecting glycosylation, and more specifically fucosylation, on proteins in biological fluids, and comparing the detected glycosylation with reference values for the glycosylation of such proteins in healthy or disease states.
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公开(公告)号：US09089515B2
公开(公告)日：2015-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
IPC分类号： A61K31/45 , A61P31/12 , A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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公开(公告)号：US20130142827A1
公开(公告)日：2013-06-06
申请号：US13805844
申请日：2011-06-24
申请人： Timothy M. Block , Anand Mehta , Pamela Norton
发明人： Timothy M. Block , Anand Mehta , Pamela Norton
IPC分类号： A61K39/29 , A61K31/45 , A61K31/437 , A61K31/7072 , A61K31/522
CPC分类号： A61K39/292 , A61K31/437 , A61K31/45 , A61K31/522 , A61K31/7072 , A61K39/12 , A61K39/29 , A61K45/06 , A61K2039/552 , A61K2039/572 , C12N7/00 , C12N2730/10122 , C12N2730/10133 , C12N2730/10134 , C12N2730/10171 , C12N2770/24222 , C12N2770/24233
摘要： Provided are methods and compositions that can be used to treat subjects having a viral infection by provoking an immune response using newly discovered antigens that are non-naturally occurring variations on viral glycoproteins. For example, provided are viral glycoproteins or a fragments thereof, or, DNA constructs encoding for such viral glycoproteins or fragments thereof, wherein the glycoprotein or fragment comprises a glycosylation sequon that includes a non-templated aspartic acid residue.
摘要翻译： 提供的方法和组合物可以用于通过使用新发现的抗原诱发免疫应答来治疗患有病毒感染的受试者，所述抗原是病毒糖蛋白上非天然存在的变体。 例如，提供的是病毒糖蛋白或其片段，或编码这种病毒糖蛋白或其片段的DNA构建体，其中糖蛋白或片段包含糖基化序列，其包含非模板天冬氨酸残基。
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公开(公告)号：US20110184019A1
公开(公告)日：2011-07-28
申请号：US13064116
申请日：2011-03-07
申请人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
发明人： Nicole Zitzmann , Terry D. Butters , Frances M. Platt , Gary S. Jacob , Donald H. Picker , Sandra Carrouee , George W. J. Fleet , Raymond A. Dwek , David Durantel , Anand Mehta , Timothy M. Block
CPC分类号： A61K31/13 , A61K31/00 , A61K31/166 , A61K31/40 , A61K31/445 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： Long chain N-alkyl amino and imino compounds, oxa-substituted derivatives thereof, and pharmaceutical compositions including such compounds are described. The long chain N-alkyl group is a C8-C16 alkyl group. The long chain N-alkyl compounds and oxa-substituted derivatives thereof can be used in the treatment of viral infections, in particular hepatitis B virus or hepatitis C virus, in a cell or an individual. For example, the long chain N-alkyl compounds or oxa-substituted derivatives thereof can be derived from piperidines, pyrrolidines, phenylamines, pyridines, pyrroles, or amino acids.
摘要翻译： 描述了长链N-烷基氨基和亚氨基化合物，其氧杂取代的衍生物和包括这些化合物的药物组合物。 长链N-烷基是C8-C16烷基。 长链N-烷基化合物及其氧杂取代的衍生物可用于治疗细胞或个体中的病毒感染，特别是乙型肝炎病毒或丙型肝炎病毒。 例如，长链N-烷基化合物或其氧杂取代的衍生物可衍生自哌啶，吡咯烷，苯胺，吡啶，吡咯或氨基酸。
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