PATHOGEN DETECTION APPARATUS AND PATHOGEN DETECTION METHOD

    公开(公告)号:US20200319106A1

    公开(公告)日:2020-10-08

    申请号:US16908788

    申请日:2020-06-23

    Abstract: A pathogen detection apparatus includes a collector that collects a pathogen in air; a reactor that causes the pathogen collected by the collector to react with a labeled substance; a time measurer that measures time from start of reaction in the reactor; a detector that detects a quantity of labeled substance that has reacted with the pathogen; and a controller. The controller calculates a gradient value on the basis of a predetermined time period from the start of reaction measured by the time measurer and the quantity of labeled substance detected by the detector, and determines, on the basis of the gradient value, a time interval to next collection that is to be performed by the collector.

    APPARATUS AND METHOD FOR MEASURING MUSCLE OXYGEN CONSUMPTION

    公开(公告)号:US20230172470A1

    公开(公告)日:2023-06-08

    申请号:US18163276

    申请日:2023-02-01

    Inventor: HIROTO YANAGAWA

    Abstract: A measurement apparatus includes a light source, a sensor with photoelectric converters, and a processing circuit. The processing circuit executes a detection operation multiple times to acquire multiple detection signals. The detection operation includes: causing the light source to emit a light pulse; and causing the sensor to detect at least part of an internal scattering component of a reflected light pulse, and output a detection signal representing a spatial distribution of intensity of the at least part of the internal scattering component. The reflected light pulse arises from the target portion due to emission of the light pulse. The internal scattering component is a component scattered in an interior of the target portion. The detection signal is included in the multiple detection signals. The processing circuit, based on the multiple detection signals, generates and outputs distribution data representing a spatial distribution of muscle oxygen consumption in the target portion.

    SENSOR SUBSTRATE, DETECTION DEVICE, AND MANUFACTURING METHOD OF SENSOR SUBSTRATE

    公开(公告)号:US20200158723A1

    公开(公告)日:2020-05-21

    申请号:US16749314

    申请日:2020-01-22

    Inventor: HIROTO YANAGAWA

    Abstract: The present disclosure provides a sensor substrate capable of detecting a trace amount of an analyte. This sensor substrate according to the present disclosure is a sensor substrate comprising a metal microstructure that generates surface plasmon when irradiated with excitation light. The metal microstructure is composed of a plurality of protrusions disposed in a planar shape. The plurality of the protrusions are disposed in such a manner that imaginary lines V each passing through a center between adjacent protrusions draw a honeycomb shape in a plan view. Each of the plurality of the protrusions has a substantially hexagonal shape in the plan view. A depth in a thickness direction of the sensor substrate of a gap present between the adjacent protrusions is larger than a radius of an imaginary circle inscribed in a hexagon forming the honeycomb shape.

    BIOLOGICAL MEASUREMENT DEVICE, BIOLOGICAL MEASUREMENT METHOD, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM

    公开(公告)号:US20230301536A1

    公开(公告)日:2023-09-28

    申请号:US18327928

    申请日:2023-06-02

    CPC classification number: A61B5/0261 A61B5/4064

    Abstract: A biological measurement device includes a light emitting device, a sensor, and a processing circuit. The light emitting device irradiates a first region and a second region, which is located on an upper side relative to the first region, of a forehead of a subject with light. The sensor detects first scattering light generated by the light incident on the first region and second scattering light generated by the light incident on the second region and outputs detection signals according to intensities of the first and second scattering light. The processing circuit selects one of the first and second regions as a target region based on the detection signals and/or an image signal indicative of an image including a face of the subject and generates and outputs brain activity data indicative of a state of brain activity of the subject based on the detection signal in the selected target region.

    METAL MICROSCOPIC STRUCTURE AND DETECTION DEVICE

    公开(公告)号:US20210025884A1

    公开(公告)日:2021-01-28

    申请号:US17071578

    申请日:2020-10-15

    Abstract: One non-limiting and exemplary embodiment provides a metal microscopic structure capable of detecting a low-concentration analyte with high sensitivity. The metal microscopic structure includes a base member including multiple protrusions arrayed at predetermined intervals, and multiple projections made of a metal film covering the base member and configured to generate surface plasmons upon irradiation with light. A film thickness of the metal film positioned in a bottom portion of a gap between every adjacent two of the multiple projections is greater than a height of the multiple protrusions and is more than or equal to 90% and less than or equal to 100% of a film thickness of the metal film deposited on top portions of the multiple protrusions.

    DETECTION DEVICE AND DETECTION METHOD
    8.
    发明申请

    公开(公告)号:US20200166455A1

    公开(公告)日:2020-05-28

    申请号:US16747021

    申请日:2020-01-20

    Abstract: The present disclosure provides a detection device capable of detecting a low concentration of an analyte with high sensitivity. The detection apparatus according to the present disclosure comprises a metal microstructure on which a first VHH antibody having a property of binding specifically to the analyte is immobilized and which generate surface plasmon by being irradiated with excitation light, an inlet through which a second VHH antibody and a sample that may contain an analyte are introduced, wherein the second VHH antibody has a property of binding specifically to the analyte and is labeled with a fluorescent substance, a light source for irradiating the metal microstructure to which the second VHH antibody and the sample have been introduced with the excitation light, and a detection unit for detecting the analyte on the basis of fluorescence generated from the fluorescent substance by the irradiation of the excitation light.

    SENSOR SUBSTRATE AND METHOD OF PRODUCING THE SENSOR SUBSTRATE

    公开(公告)号:US20210041358A1

    公开(公告)日:2021-02-11

    申请号:US17077444

    申请日:2020-10-22

    Inventor: HIROTO YANAGAWA

    Abstract: The present disclosure provides a sensor substrate that detects an analyte of a low concentration with high sensitivity and high reliability. The sensor substrate according to the present disclosure a first substrate having first microprotrusions provided on the surface thereof and covered by a metal film, an adhesive film disposed on the surface of the first substrate and having a slit, and a second substrate that is transparent, disposed on the adhesive film, and having a first through hole and a second through hole, wherein each of the first through hole and the second through hole is in communication with the slit, and the first microprotrusions overlap the slit in a plan view.

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