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    BUFFER MANAGEMENT AND IDENTIFICATION IN BIOPROCESSING SYSTEM
    1.
    发明申请
    BUFFER MANAGEMENT AND IDENTIFICATION IN BIOPROCESSING SYSTEM 有权

    公开(公告)号：US20210199679A1

    公开(公告)日：2021-07-01

    申请号：US17127178

    申请日：2020-12-18

    申请人： Pall Corporation

    发明人： Michael B. Seal ,  Darren G. Elton ,  Bojan Isailovic ,  Jeremy Rautenbach

    IPC分类号： G01N35/00 ,  G01N35/10

    摘要： A buffer management system includes at least one workstation configured to support a supply of concentrated buffer solution and an inline dilution skid having a manifold and at least one workstation to support delivery of diluted (surge) buffers from the inline dilution skid. The latter workstation also serves to supply ready-made (diluted) buffers to a bioprocessing unit. The manifold is in fluid communication with the supply of concentrated buffer solution and is adapted to be placed in fluid communication with a source of water for injection (WFI). The inline dilution skid is configured to variably mix the supply of concentrated buffer solution and the source of WFI to obtain a range of diluted buffer solutions. Processes for automatically identifying the arrangement of buffer solutions in a bioprocessing application use signals from various sensors to identify the fluid connections between components of the system.

    BUFFER MANAGEMENT FOR BIOPROCESSING SYSTEM
    2.
    发明申请
    BUFFER MANAGEMENT FOR BIOPROCESSING SYSTEM 有权

    公开(公告)号：US20210197189A1

    公开(公告)日：2021-07-01

    申请号：US17127138

    申请日：2020-12-18

    申请人： Pall Corporation

    发明人： Bojan Isailovic ,  Michael B. Seal ,  Matthew J. Loveless ,  Robert Flisar ,  Damir F. Söhngen

    IPC分类号： B01L3/00 ,  G01F23/26

    摘要： A buffer management system includes a supply of concentrated buffer solution, an inline dilution skid having a manifold in fluid communication with the supply of concentrated buffer solution and a control unit configured to operate the dilution skid to selectively dilute the supply of concentrated buffer solution in the manifold with a source of water for injection (WFI), and a biocontainer assembly. The biocontainer assembly includes a biocontainer bag defining a storage volume and a fill level sensor configured to generate a fill level signal indicative of the amount of material within the storage volume of the biocontainer bag. The biocontainer bag is in fluid communication with the manifold of the dilution skid for storing diluted buffer solution therein. The fill level sensor communicates the fill level signal to the control unit of the dilution skis, which uses it to manage the operation of the dilution skid.

    FLUID DISTRIBUTION SYSTEM WITH SINGLE USE MANIFOLD ASSEMBLY FOR SCALED FILLING
    3.
    发明公开
    FLUID DISTRIBUTION SYSTEM WITH SINGLE USE MANIFOLD ASSEMBLY FOR SCALED FILLING 审中-公开

    公开(公告)号：US20230211905A1

    公开(公告)日：2023-07-06

    申请号：US17934962

    申请日：2022-09-23

    申请人： Pall Corporation

    发明人： Michael B. Seal ,  Bojan Isailovic ,  Robert Flisar ,  Jeremy Rautenbach

    IPC分类号： B65B3/00 ,  B65B3/34

    CPC分类号： B65B3/003 ,  B65B3/34

    摘要： A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.

    FLUID DISTRIBUTION SYSTEM WITH SINGLE USE MANIFOLD FLUID RECOVERY ASSEMBLY
    4.
    发明公开
    FLUID DISTRIBUTION SYSTEM WITH SINGLE USE MANIFOLD FLUID RECOVERY ASSEMBLY 审中-公开

    公开(公告)号：US20230211994A1

    公开(公告)日：2023-07-06

    申请号：US17934486

    申请日：2022-09-22

    申请人： Pall Corporation

    发明人： Thomas J. Hartridge ,  Bojan Isailovic ,  Jens Bretschneider

    IPC分类号： B67C3/28 ,  B67C3/00

    CPC分类号： B67C3/282 ,  B67C3/007

    摘要： A fluid distribution system includes single use distributor manifolds each having a distributor manifold inlet and a plurality of distributor manifold outlets in fluid communication with the distributor manifold inlet. A set of single use filler manifolds can be sequentially connected to a respective one of the outlets of a single use distributor manifold immediately upstream of the connection point of the set of single use filler manifolds. In embodiments, an upstream distributor manifold can be used to feed fluid to a set of intermediary distributor manifolds where the set of intermediary distributor manifolds corresponds to the number of outlets of the upstream distributor manifold.