公开(公告)号：US20190022293A1

公开(公告)日：2019-01-24

申请号：US16138441

申请日：2018-09-21

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: A61M1/16 ,  F24H1/12 ,  C02F1/02 ,  B01D61/08 ,  B01D61/18 ,  B01D61/30 ,  B01D61/58 ,  C02F1/00 ,  C02F1/20 ,  C02F1/28 ,  C02F1/44 ,  C02F9/00 ,  B01D61/14 ,  B01D61/02 ,  C02F103/02

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

公开(公告)号：US10105476B2

公开(公告)日：2018-10-23

申请号：US14808827

申请日：2015-07-24

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: A61M1/16 ,  B01D61/08 ,  B01D61/18 ,  C02F1/20 ,  C02F1/44 ,  B01D61/30 ,  C02F1/02 ,  C02F1/28 ,  C02F9/00 ,  F24H1/12 ,  B01D61/58 ,  C02F1/00 ,  B01D61/02 ,  B01D61/14 ,  C02F103/02

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

公开(公告)号：US20150328386A1

公开(公告)日：2015-11-19

申请号：US14808827

申请日：2015-07-24

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: A61M1/16 ,  B01D61/58 ,  B01D61/08 ,  C02F1/02 ,  C02F1/00 ,  C02F1/28 ,  C02F1/44 ,  C02F1/20 ,  C02F9/00 ,  B01D61/18

CPC classification number: A61M1/1686 ,  A61M1/1658 ,  A61M1/1672 ,  A61M2205/75 ,  B01D61/025 ,  B01D61/08 ,  B01D61/145 ,  B01D61/18 ,  B01D61/30 ,  B01D61/58 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  C02F1/001 ,  C02F1/02 ,  C02F1/20 ,  C02F1/283 ,  C02F1/441 ,  C02F1/444 ,  C02F9/005 ,  C02F2103/026 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/03 ,  C02F2301/043 ,  C02F2301/046 ,  C02F2303/04 ,  F24H1/121 ,  B01D2311/2649 ,  B01D2311/103 ,  B01D2311/2653

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

Abstract translation: 某些公开的实施方案涉及制备在家用透析系统中使用的透析液的系统和方法，该系统和方法相对于现有系统而言紧凑且重量轻并且消耗相对低的能量。 该方法包括将家用水流连接到透析系统; 过滤水流; 在非分批方法中将水流加热到至少约138摄氏度以产生加热的水流; 将加热的水流维持在至少约138摄氏度以上至少约2秒; 冷却加热的水流以产生冷却的水流; 超滤冷却水流; 并以非分批方法将透析液组分混合到冷却水流中。

公开(公告)号：US20210069401A1

公开(公告)日：2021-03-11

申请号：US17028130

申请日：2020-09-22

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: A61M1/16 ,  B01D61/08 ,  B01D61/18 ,  C02F1/20 ,  B01D61/58 ,  C02F1/00 ,  C02F1/02 ,  C02F1/28 ,  C02F1/44 ,  F24H1/12 ,  C02F9/00

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

公开(公告)号：US10668201B2

公开(公告)日：2020-06-02

申请号：US15865547

申请日：2018-01-09

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Julie S. Wrazel ,  James R. Curtis ,  Ladislaus Nonn ,  Richard B. Peterson ,  Hailei Wang ,  Robbie Ingram-Goble ,  Luke W. Fisher ,  Anna E. Garrison ,  M. Kevin Drost ,  Goran Jovanovic ,  Richard Todd Miller ,  Bruce W. Johnson ,  Alana Anderson ,  Eric K. Anderson

IPC: A61M1/16 ,  B01D63/08 ,  C02F1/02 ,  C02F9/00 ,  F24H1/12 ,  A61M1/14 ,  C02F1/44 ,  C02F1/20 ,  C02F1/28 ,  C02F103/02 ,  F28F3/08 ,  F28D7/12 ,  F24H9/00 ,  F28D21/00

Abstract: A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

公开(公告)号：US20180126056A1

公开(公告)日：2018-05-10

申请号：US15865547

申请日：2018-01-09

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Julie S. Wrazel ,  James R. Curtis ,  Ladislaus Nonn ,  Richard B. Peterson ,  Hailei Wang ,  Robbie Ingram-Goble ,  Luke W. Fisher ,  Anna E. Garrison ,  M. Kevin Drost ,  Goran Jovanovic ,  Richard Todd Miller ,  Bruce W. Johnson ,  Alana Anderson ,  Eric K. Anderson

IPC: A61M1/16 ,  C02F9/00 ,  A61M1/14 ,  C02F1/44 ,  B01D63/08 ,  F24H1/12 ,  C02F1/02 ,  C02F1/28 ,  C02F1/20 ,  C02F103/02 ,  F24H9/00 ,  F28D7/12 ,  F28D21/00 ,  F28F3/08

Abstract: A dialysis system includes a filtration system capable of filtering a water stream, a water purification system capable of purifying said water stream in a non-batch process, a mixing system capable of producing a stream of dialysate from mixing one or more dialysate components with the water stream in a non-batch process, and a dialyzer system. The dialyzer may be a microfluidic dialyzer capable of being fluidly coupled to the stream of dialysate and a blood stream.

公开(公告)号：US09138687B2

公开(公告)日：2015-09-22

申请号：US13965720

申请日：2013-08-13

Applicant: Oregon State University ,  Outset Medical, Inc.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: B01D61/30 ,  C02F9/00 ,  C02F1/02 ,  C02F1/44 ,  B01D61/58 ,  F24H1/12 ,  B01D61/02 ,  B01D61/14 ,  C02F1/00 ,  C02F1/28 ,  C02F103/02

CPC classification number: A61M1/1686 ,  A61M1/1658 ,  A61M1/1672 ,  A61M2205/75 ,  B01D61/025 ,  B01D61/08 ,  B01D61/145 ,  B01D61/18 ,  B01D61/30 ,  B01D61/58 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  C02F1/001 ,  C02F1/02 ,  C02F1/20 ,  C02F1/283 ,  C02F1/441 ,  C02F1/444 ,  C02F9/005 ,  C02F2103/026 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/03 ,  C02F2301/043 ,  C02F2301/046 ,  C02F2303/04 ,  F24H1/121 ,  B01D2311/2649 ,  B01D2311/103 ,  B01D2311/2653

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.

Abstract translation: 某些公开的实施方案涉及制备在家用透析系统中使用的透析液的系统和方法，该系统和方法相对于现有系统而言紧凑且重量轻并且消耗相对低的能量。 该方法包括将家用水流连接到透析系统; 过滤水流; 在非分批方法中将水流加热到至少约138摄氏度以产生加热的水流; 将加热的水流维持在至少约138摄氏度以上至少约2秒; 冷却加热的水流以产生冷却的水流; 超滤冷却水流; 并以非分批方法将透析液组分混合到冷却水流中。

公开(公告)号：US12201762B2

公开(公告)日：2025-01-21

申请号：US16550042

申请日：2019-08-23

Applicant: OUTSET MEDICAL, INC.

Inventor： Michael Edward Hogard ,  Dean Hu ,  Shih-Paul Chen ,  James Ritson ,  Gopi K. Lingam ,  Peter Velasco Obico ,  James R. Curtis ,  Steven M. Miller

IPC: A61M1/00 ,  A61M1/16 ,  A61M1/28 ,  A61M1/36

Abstract: Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration.

公开(公告)号：US09545469B2

公开(公告)日：2017-01-17

申请号：US15225712

申请日：2016-08-01

Applicant: OUTSET MEDICAL, INC.

Inventor： James R. Curtis ,  Ladislaus F. Nonn ,  Julie Wrazel

IPC: A61M1/16 ,  A61M1/34 ,  G05D7/06

CPC classification number: A61M1/1647 ,  A61M1/16 ,  A61M1/1601 ,  A61M1/1619 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3413 ,  A61M1/3427 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/70 ,  A61M2205/702 ,  G05D7/0676

Abstract: Systems and methods are disclosed for performing hemodialysis that include fluid handling systems that provide accurate control over the type and level of hemodialysis being performed. The system includes a first pump for pumping dialysate into a dialyzer and a second pump for pumping dialysate out of the dialyzer. The system also includes a third pump that provides improved control of a level of ultrafiltration, hemodiafiltration, or both.

Abstract translation: 公开了用于执行血液透析的系统和方法，其包括提供对正在执行的血液透析的类型和水平的精确控制的流体处理系统。 该系统包括用于将透析液泵入透析器的第一泵和用于将透析液泵出透析器的第二泵。 该系统还包括第三泵，其提供对超滤水平，血液透析滤液或两者的改进的控制。

公开(公告)号：US11724013B2

公开(公告)日：2023-08-15

申请号：US17028130

申请日：2020-09-22

Applicant: OUTSET MEDICAL, INC.

Inventor： Richard B. Peterson ,  James R. Curtis

IPC: A61M1/16 ,  B01D61/08 ,  B01D61/18 ,  C02F1/02 ,  C02F1/44 ,  B01D61/02 ,  B01D61/14 ,  C02F1/20 ,  B01D61/58 ,  C02F1/00 ,  C02F1/28 ,  F24H1/12 ,  C02F9/20 ,  C02F103/02

CPC classification number: A61M1/1686 ,  A61M1/1658 ,  A61M1/1672 ,  B01D61/08 ,  B01D61/18 ,  B01D61/58 ,  C02F1/001 ,  C02F1/02 ,  C02F1/20 ,  C02F1/283 ,  C02F1/441 ,  C02F1/444 ,  C02F9/20 ,  F24H1/121 ,  A61M2205/75 ,  B01D61/025 ,  B01D61/145 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/25 ,  C02F2103/026 ,  C02F2209/005 ,  C02F2209/006 ,  C02F2209/03 ,  C02F2301/043 ,  C02F2301/046 ,  C02F2303/04 ,  B01D2311/04 ,  B01D2311/2649 ,  B01D2311/06 ,  B01D2311/103 ,  B01D2311/2653

Abstract: Certain disclosed embodiments concern systems and methods of preparing dialysate for use in a home dialysis system that is compact and light-weight relative to existing systems and consumes relatively low amounts of energy. The method includes coupling a household water stream to a dialysis system; filtering the water stream; heating the water stream to at least about 138 degrees Celsius in a non-batch process to produce a heated water stream; maintaining the heated water stream at or above at least about 138 degrees Celsius for at least about two seconds; cooling the heated water stream to produce a cooled water stream; ultrafiltering the cooled water stream; and mixing dialysate components into the cooled water stream in a non-batch process.