公开(公告)号：US11013576B2

公开(公告)日：2021-05-25

申请号：US15535665

申请日：2016-10-13

Applicant: OPKO Diagnostics, LLC

Inventor： Jason Taylor ,  David Steinmiller ,  Hardeep Singh ,  Rebecca Wagner ,  Gary J. Fagan ,  Vincent Linder

IPC: A61B90/80 ,  A61B5/15 ,  A61L2/18 ,  B08B1/00 ,  B08B3/08 ,  C11D3/48 ,  C11D17/04 ,  C11D11/00

Abstract: Articles and methods for preparing a surface for obtaining a patient sample, such as blood, are generally provided. In some embodiments, the methods involve wiping a surface of skin of a patient in preparation for obtaining a sample (e.g., a blood sample) from the patient. In some embodiments, the methods involve wiping the surface of the skin with two or more wipes. For instance, the surface of the skin may be wiped with a first wipe comprising a surfactant and a second wipe comprising an antiseptic solution. Advantageously, the use of a first wipe including a surfactant followed by a second wipe may remove a higher amount of certain contaminants (e.g., proteins, bacteria, viruses) from the surface of the skin as compared to the use of a single wipe or by hand-washing alone.

公开(公告)号：US10953398B2

公开(公告)日：2021-03-23

申请号：US15828999

申请日：2017-12-01

Applicant: OPKO Diagnostics, LLC

Inventor： Enqing Tan ,  Vincent Linder ,  Jason Taylor ,  David Steinmiller

IPC: F16K11/20 ,  B01L3/00 ,  G01N33/543

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

公开(公告)号：US09861980B2

公开(公告)日：2018-01-09

申请号：US15385117

申请日：2016-12-20

Applicant: OPKO Diagnostics, LLC

Inventor： Enqing Tan ,  Vincent Linder ,  Jason Taylor ,  David Steinmiller

IPC: F16K11/02 ,  B01L3/00

CPC classification number: B01L3/502723 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N33/54366 ,  Y10T137/0318 ,  Y10T137/0329 ,  Y10T137/86292 ,  Y10T137/87652

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

公开(公告)号：US20170167958A1

公开(公告)日：2017-06-15

申请号：US15443453

申请日：2017-02-27

Applicant: OPKO Diagnostics, LLC

Inventor： Matthew Dirckx ,  Vincent Linder ,  Jason Taylor

IPC: G01N1/38 ,  B01F13/00 ,  B01F3/08 ,  B01L3/00 ,  B01F3/04

Abstract: Fluidic devices and methods associated with mixing of fluids in fluidic devices are provided. In some embodiments, a method may involve the mixing of two or more fluids in a channel segment of a fluidic device. The fluids may be in the form of, for example, at least first, second and third fluid plugs, composed of first, second, and third fluids, respectively. The second fluid may be immiscible with the first and third fluids. In certain embodiments, the fluid plugs may be flowed in series in the channel segment, e.g., in linear order, causing the first and third fluids to mix without the use of active components such as mixers. The mixing of fluids in a channel segment as described herein may allow for improved performance and simplification in the design and operations of fluidic devices that rely on mixing of fluids.

公开(公告)号：US10589265B2

公开(公告)日：2020-03-17

申请号：US15840159

申请日：2017-12-13

Applicant: OPKO Diagnostics, LLC

Inventor： Jason Taylor ,  Vincent Linder

IPC: B01L3/00

Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

公开(公告)号：US10456784B2

公开(公告)日：2019-10-29

申请号：US15588548

申请日：2017-05-05

Applicant: OPKO Diagnostics, LLC

Inventor： Vincent Linder ,  David Steinmiller ,  Jason Taylor

IPC: B01L3/00 ,  G01N21/59 ,  G01N33/543 ,  G01N33/574 ,  G01N21/05 ,  G01N21/64 ,  G01N21/76 ,  B01L7/00

Abstract: Systems and methods for analysis of samples, and in certain embodiments, microfluidic sample analyzers configured to receive a cassette containing a sample therein to perform an analysis of the sample are described. The microfluidic sample analyzers may be used to control fluid flow, mixing, and sample analysis in a variety of microfluidic systems such as microfluidic point-of-care diagnostic platforms. Advantageously, the microfluidic sample analyzers may be, in some embodiments, inexpensive, reduced in size compared to conventional bench top systems, and simple to use. Cassettes that can operate with the sample analyzers are also described.

公开(公告)号：US20180099272A1

公开(公告)日：2018-04-12

申请号：US15840159

申请日：2017-12-13

Applicant: OPKO Diagnostics, LLC

Inventor： Jason Taylor ,  Vincent Linder

IPC: B01L3/00

CPC classification number: B01L3/5027 ,  B01L3/527 ,  B01L3/561 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0487

Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

公开(公告)号：US20180078938A1

公开(公告)日：2018-03-22

申请号：US15828999

申请日：2017-12-01

Applicant: OPKO Diagnostics, LLC

Inventor： Enqing Tan ,  Vincent Linder ,  Jason Taylor ,  David Steinmiller

IPC: B01L3/00

CPC classification number: B01L3/502723 ,  B01L3/5027 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/0673 ,  B01L2200/0684 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2400/0487 ,  B01L2400/0694 ,  G01N33/54366 ,  Y10T137/0318 ,  Y10T137/0329 ,  Y10T137/86292 ,  Y10T137/87652

Abstract: The specification generally discloses systems and methods for mixing and delivering fluids in microfluidic systems. The fluids can contain, in some embodiments reagents that can participate in one or more chemical or biological reactions. Some embodiments relate to systems and methods employing one or more vent valves to controllably flow and/or mix portions of fluid within the microfluidic system. Advantageously, fluid control such as a sequence of fluid flow and/or a change in flow rate, can be achieved by opening and closing one or more vent valves and by applying a single source of fluid flow (e.g., a vacuum) operated at a substantially constant pressure. This can simplify the operation and use of the device by an intended user.

公开(公告)号：US09878324B2

公开(公告)日：2018-01-30

申请号：US15388442

申请日：2016-12-22

Applicant: OPKO Diagnostics, LLC

Inventor： Jason Taylor ,  Vincent Linder

IPC: B01L3/00

CPC classification number: B01L3/5027 ,  B01L3/527 ,  B01L3/561 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0487

Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

公开(公告)号：US09561506B2

公开(公告)日：2017-02-07

申请号：US14035885

申请日：2013-09-24

Applicant: OPKO Diagnostics, LLC

Inventor： Jason Taylor ,  Vincent Linder

IPC: B01L3/00

CPC classification number: B01L3/5027 ,  B01L3/527 ,  B01L3/561 ,  B01L2200/0673 ,  B01L2200/12 ,  B01L2200/142 ,  B01L2200/16 ,  B01L2300/069 ,  B01L2300/0809 ,  B01L2300/0874 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/0487

Abstract: Fluidic devices and methods including those that provide storage and/or facilitate fluid handling of reagents are provided. Fluidic devices described herein may include channel segments positioned on two sides of an article, optionally connected by an intervening channel passing through the article. The channel segments may be used to store reagents in the device prior to first use by an end user. The stored reagents may include fluid plugs positioned in linear order so that during use, as fluids flow to a reaction site, they are delivered in a predetermined sequence. The specific geometries of the channel segments and the positions of the channel segments within the fluidic devices described herein may allow fluid reagents to be stored for extended periods of time without mixing, even during routine handling of the devices such as during shipping of the devices, and when the devices are subjected to physical shock or vibration.

Abstract translation: 提供了流体装置和方法，包括提供储存和/或促进试剂的流体处理的流体装置和方法。 本文描述的流体装置可以包括定位在物品两侧的通道段，可选地通过穿过物品的居间通道连接。 通道段可以用于在终端用户首次使用之前将试剂存储在设备中。 储存的试剂可以包括以线性顺序定位的流体塞，使得在使用期间，当流体流到反应部位时，它们以预定的顺序递送。 通道段的特定几何形状和本文所述的流体装置内的通道段的位置可以允许流体试剂在不混合的情况下长时间储存​​，即使在设备的例行处理期间，例如装置运输期间， 并且当设备遭受物理冲击或振动时。