公开(公告)号：US20220155213A1

公开(公告)日：2022-05-19

申请号：US17591006

申请日：2022-02-02

Applicant: OLYMPUS CORPORATION

Inventor： Takuma DEZAWA ,  Tomio ENDO

IPC: G01N15/14 ,  C12N5/078 ,  G01N21/47

Abstract: An erythrocyte differentiation monitoring apparatus includes a laser light source that radiates a pulsed laser beam in a hemoglobin absorption wavelength range onto a cell within a culture container, a probe that receives a photoacoustic wave emitted from the cell within the culture container as a result of the cell being irradiated with the pulsed laser beam emitted from the laser light source, and a processor that evaluates the progress of differentiation of the cell into an erythrocyte based on the intensity of the photoacoustic wave received by the probe.

公开(公告)号：US20220326144A1

公开(公告)日：2022-10-13

申请号：US17680624

申请日：2022-02-25

Applicant: OLYMPUS CORPORATION

Inventor： Takuma DEZAWA

IPC: G01N21/17 ,  C12N5/071 ,  C12N5/079 ,  C12M1/00 ,  C12M1/34 ,  G01N33/50

Abstract: A device for evaluating progression of differentiation from pluripotent stem cells to pigment-containing cells includes a first irradiation unit configured to irradiate cells in a vessel with light in a melanin absorption wavelength band, a first detection unit configured to detect photo-acoustic waves generated from the cells irradiated with the light, and a processor configured to output an evaluation result relevant to the progression of the differentiation of the cells to the pigment-containing cells, based on intensity of the detected photo-acoustic waves detected by the first detection unit.

公开(公告)号：US20220301164A1

公开(公告)日：2022-09-22

申请号：US17675180

申请日：2022-02-18

Applicant: OLYMPUS CORPORATION

Inventor： Yoko KAMATO ,  Elena SHIMOJI ,  Takuma DEZAWA

IPC: G06T7/00 ,  C12M1/36 ,  C12M1/24 ,  C12M1/06

Abstract: A culture management apparatus includes a control device that estimates a state of a specific medium component constituting a culture medium based on images including both the culture medium and a cell in the culture medium acquired by an imaging device at different times.

公开(公告)号：US20220109786A1

公开(公告)日：2022-04-07

申请号：US17493373

申请日：2021-10-04

Applicant: OLYMPUS CORPORATION

Inventor： Akira MATSUSHITA ,  Naoyuki MIYASHITA ,  Takuma DEZAWA

IPC: H04N5/235 ,  H04N5/04 ,  G02B23/24

Abstract: An endoscope system includes an endoscope including an insertion unit and a sensor. The sensor is disposed at a distal end of the insertion unit. The sensor unit includes a motion sensor and a light source. The motion sensor is configured to execute a measurement operation and generate a measurement value indicating a measurement result. The light source is configured to generate light indicating the measurement operation at a timing that is synchronized with the measurement operation. The insertion unit includes an imaging device disposed at the distal end and configured to receive the light generated by the light source and generate an image.

公开(公告)号：US20200311922A1

公开(公告)日：2020-10-01

申请号：US16829162

申请日：2020-03-25

Applicant: OLYMPUS CORPORATION

Inventor： Satoshi HARA ,  Jun SUGAWARA ,  Keiji OKADA ,  Mikako HORI ,  Takuma DEZAWA ,  Masaaki YAMAGISHI ,  Kazuhiko OSA ,  Osamu NONAKA

IPC: G06T7/00 ,  C12M1/34 ,  G06T1/20

Abstract: An cell observation system, comprising an image sensor capable of movement in a horizontal direction, and a processor, wherein the processor infers position where a colony will be generated or grown from position information or shape information of a plurality of cells within an image, based on the image of the cells that has been acquired by the image sensor, and controls position of the image sensor so as to perform imaging at the inferred position.

公开(公告)号：US20220267710A1

公开(公告)日：2022-08-25

申请号：US17582244

申请日：2022-01-24

Applicant: OLYMPUS CORPORATION

Inventor： Elena SHIMOJI ,  Takuma DEZAWA ,  Yoko KAMATO

IPC: C12M1/34 ,  C12M1/36 ,  C12M1/00

Abstract: A cell collecting apparatus includes: a culturing device having a culture vessel and a collecting channel; and a control device. The culturing device cultures cells in a state where the cells are suspended in a liquid medium stored in the culture vessel. The control device controls the culturing device such that a suspension height, which is a height at which the target cell is suspended in the liquid medium, approaches a collection height, which is a height of an inlet of the collecting channel, the inlet configured to be used for cell collection from inside the culture vessel.

公开(公告)号：US20220196520A1

公开(公告)日：2022-06-23

申请号：US17529426

申请日：2021-11-18

Applicant: OLYMPUS CORPORATION

Inventor： Takuma DEZAWA ,  Yoko KAMATO ,  Elena SHIMOJI

IPC: G01N1/14 ,  G06K9/00 ,  C12Q3/00 ,  B01L3/00 ,  G01N15/10

Abstract: A cell recovery apparatus includes an observation apparatus for observing the inside of a medium in a container via an insertion section to be inserted into the medium, and a recovery apparatus that is positioned relative to a predetermined region to be observed by the observation apparatus and recovers a cell in the medium from the container.

公开(公告)号：US20200224142A1

公开(公告)日：2020-07-16

申请号：US16708823

申请日：2019-12-10

Applicant: OLYMPUS CORPORATION

Inventor： Takuma DEZAWA

IPC: C12M1/12 ,  C12M1/06 ,  C12M1/34 ,  C12M1/00

Abstract: The frequency at which a culture medium is replaced is reduced by prolonging the service life of the culture medium, the size of a device is reduced, cost is reduced, and a mechanical strength is enhanced. Provided is a cell culture device including: a culture container capable of accommodating cells and a culture solution; and an adsorbing member that is formed of a porous material having adsorption holes, the hole diameters of which are smaller than the cells and larger than impurities in the culture solution, and that adsorbs the impurities, without adsorbing the cells, in the culture solution by means of the adsorption holes while at least a portion of the adsorbing member is immersed in the culture solution in the culture container.

公开(公告)号：US20220146404A1

公开(公告)日：2022-05-12

申请号：US17581364

申请日：2022-01-21

Applicant: OLYMPUS CORPORATION

Inventor： Akira MATSUSHITA ,  Yu HIROSAWA ,  Taiji MINE ,  Takuma DEZAWA

IPC: G01N15/14 ,  G01N33/50 ,  G06T7/00 ,  G06N20/00 ,  G01N35/00

Abstract: A method for displaying cell count information includes steps for: obtaining a cell image; obtaining a first cell count output by applying the cell image to a first counting model; obtaining a second cell count output by applying the cell image to a second counting model; and displaying, on the basis of the first and second cell counts, a screen on which at least either of the first and second cell counts and a correlation between the first and second cell counts are visualized. The first counting model is different from the second counting model.

公开(公告)号：US20220130043A1

公开(公告)日：2022-04-28

申请号：US17568925

申请日：2022-01-05

Applicant: OLYMPUS CORPORATION

Inventor： Akira MATSUSHITA ,  Isao SAKANE ,  Yu HIROSAWA ,  Takuma DEZAWA

IPC: G06T7/00 ,  C12M1/00 ,  C12M3/00 ,  C12M1/12

Abstract: A method for evaluating an adherent cell includes: obtaining an image of an adherent cell accommodated within a culture container; and determining whether the adherent cell is adhering to the culture container based on at least a profile shape of a contact portion of the adherent cell that is in contact with the culture container, the profile shape being specified from the image.