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公开(公告)号：US20190137749A1
公开(公告)日：2019-05-09
申请号：US16238585
申请日：2019-01-03
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA , Masaki HIGURASHI
摘要： An observation device includes: an illumination optical system that irradiates illumination light onto a sample, an objective optical system that has a phase modulation region and a light blocking region and that acquires an image of the illumination light transmitted through the sample, and an autofocus mechanism. The objective optical system selectively outputs the illumination light from a first output region disposed at a position where the illumination light is to be projected onto the phase modulation region and a second output region disposed at a position where a portion of the illumination light is to be projected onto the light blocking region. The autofocus mechanism causes the objective optical system to acquire an image of the illumination light while causing the illumination light to be output from the second output region, and detects the focus position of the objective optical system based on the contrast of the acquired image.
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公开(公告)号：US20180267285A1
公开(公告)日：2018-09-20
申请号：US15984949
申请日：2018-05-21
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA , Shintaro TAKAHASHI
CPC分类号： G02B21/088 , G02B21/04 , G02B21/14 , G02B21/24
摘要： An observation device includes an illuminating optical system that emits illuminating light obliquely upward from below a sample; and an objective optical system that images transmitted light, which is the illuminating light emitted from the illuminating optical system, reflected above the sample, and passed through the sample, the objective optical system imaging the transmitted light below the sample and via a different path from that of the illuminating optical system. The illuminating optical system includes a light source, a mask that restricts light, which is emitted from the light source, to a particular emission region, and a collimating optical system that converts the light restricted by the mask into substantially parallel light, and the illuminating optical system is arranged so that when the region is projected onto a pupil plane of the objective optical system, a projected image of the region partially overlaps a peripheral portion of the pupil.
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公开(公告)号：US20190187451A1
公开(公告)日：2019-06-20
申请号：US16284071
申请日：2019-02-25
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
CPC分类号： G02B21/084 , G02B3/08 , G02B21/06 , G02B21/088 , G02B21/26 , G02B21/361 , G03B15/02
摘要： An observation apparatus includes: a stage on which a container accommodating a specimen is mounted; a light source generating illumination light emitted in an upward direction from below the specimen on a specimen placement surface; a light-collecting lens disposed parallel to the surface and collecting the light; a diffusion plate disposed between the lens and the surface, parallel to the surface, and diffusing the light collected by the lens; an objective optical system disposed below the stage and collecting light passing through the stage from thereabove; and an image-capturing optical system capturing, below the specimen, transmitted light, which is the light emitted from the source, reflected above the specimen, transmitted through the specimen, and collected by the objective optical system, wherein the source is positioned so that an optical axis thereof is shifted from an optical axis of the lens in a direction away from the image-capturing optical system.
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公开(公告)号：US20170261732A1
公开(公告)日：2017-09-14
申请号：US15607666
申请日：2017-05-29
申请人： OLYMPUS CORPORATION
CPC分类号： G02B21/06 , C12M1/34 , G02B21/084 , G02B21/14 , G02B21/24 , G02B21/361
摘要： Provided is an observation apparatus and an observation method with which it is possible to observe imaging subjects, such as cells or the like, without labeling the imaging subjects and without causing an increase in the apparatus size. Provided is an observation apparatus including: a light-source unit that emits illumination light upward from below a sample; and an image-capturing optical system that has an objective lens that collects transmitted light, which is the illumination light emitted from the light-source unit that has passed through the sample by being reflected above the sample and that captures, below the sample, the transmitted light collected by the objective lens.
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公开(公告)号：US20220397529A1
公开(公告)日：2022-12-15
申请号：US17679401
申请日：2022-02-24
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
摘要： An observation device includes an illumination optical system provided on a lower side of an installation position of a multi-well plate, a reflector that reflects light emitted from the illumination optical system, the reflector being provided on an upper side of the installation position, and an observation optical system that condenses the light reflected by the reflector, the observation optical system being provided on the lower side of the installation position. The reflector includes a plurality of curved surfaces where the light emitted from the illumination optical system enters. Each of the plurality of curved surfaces corresponds to one or more wells included in the multi-well plate, has positive power in a first direction in which the illumination optical system and the observation optical system are aligned, and has a center of curvature at a position deviating from a central axis of a well of the multi-well plate.
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公开(公告)号：US20220091046A1
公开(公告)日：2022-03-24
申请号：US17541622
申请日：2021-12-03
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
摘要： A method for examining a culture solution containing a pH indicator and accommodated in a culture container includes: measuring, as a baseline intensity, an intensity of light that has passed through a solution and the culture container; measuring, as a measurement intensity, an intensity of light that has passed through the culture solution and the culture container; obtaining light source information including first information pertaining to the light source that is provided when measuring the baseline intensity and second information pertaining to the light source that is provided when measuring the measurement intensity; and on the basis of the baseline intensity, the measurement intensity, and the light source information, calculating an absorbance of the pH indicator at at least one wavelength included in emitted light from the light source.
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公开(公告)号：US20220026358A1
公开(公告)日：2022-01-27
申请号：US17378890
申请日：2021-07-19
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA , Takashi MIYOSHI
摘要： An observation apparatus includes a case having a transmissive window, an image sensor, an optical system, and a light source housed in the case, and an optical deflection unit. The optical system is configured to condense light incident inside the case to form an image of a sample inside a container. The light source is configured to emit light to the outside of the case without passing through the optical system. The optical deflection unit is configured to deflect light emitted to the outside of the case from the light source to a first direction proceeding toward the transmissive window. An angle of exit between the first direction and an optical axis of the optical system is different from an angle of incidence between a second direction in which light emitted to the outside of the case is incident on the optical deflection unit, and the optical axis.
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8.发明申请公开(公告)号：US20170115180A1
公开(公告)日：2017-04-27
申请号：US15402466
申请日：2017-01-10
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
CPC分类号： G02B27/0068 , A61B3/1015 , A61B3/14 , G02B21/0032 , G02B21/0056 , G02B21/0068 , G02B21/0072 , G02B21/0076
摘要： A phase-modulation-element adjustment system including: a positional-relationship adjustment unit that is used for a laser-scanning confocal observation apparatus including a plurality of image-forming lenses for forming a final image and at least one intermediate image and a wavefront-disturbing element and a wavefront-restoring element being placed at positions between which any of the intermediate images formed by the image-forming lenses is disposed and having opposite phase characteristics to each other and that is capable of adjusting a relative positional relationship between the wavefront-disturbing element and the wavefront-restoring element; a wavefront-aberration measurement unit for measuring a wavefront aberration of light that has come from an object and that has passed through the wavefront-disturbing element and the wavefront-restoring element; and a processor for controlling the positional-relationship adjustment unit so that the wavefront aberration measured by the wavefront-aberration measurement unit decreases.
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公开(公告)号：US20210011270A1
公开(公告)日：2021-01-14
申请号：US17015321
申请日：2020-09-09
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
IPC分类号： G02B21/20 , G02B21/00 , G02B21/26 , G01N33/483 , H04N5/369
摘要： An observation device includes: first objective lenses arranged in a row so as to be parallel to one another; second objective lenses arranged in a row so as to be parallel to one another; and image capturing elements for capturing first images formed by the first objective lenses and second images formed by the second objective lenses, respectively, wherein each of the objective lenses is a magnifying objective lens, a first axis of light incident on the first objective lenses and a second axis of light incident on the second objective lenses are parallel to one another, fields of view of the first objective lenses and fields of view of the second objective lenses are arranged alternately in a row on an observation line, and the first images and the second images are arranged in a row in image-forming regions that are disposed at positions different from each other.
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公开(公告)号：US20200088985A1
公开(公告)日：2020-03-19
申请号：US16689671
申请日：2019-11-20
申请人： OLYMPUS CORPORATION
发明人： Tadashi HIRATA
IPC分类号： G02B21/14
摘要： An observation device includes: an illumination optical system configured to emit illumination light to above a sample from below; and an objective optical system configured to acquire an image of transmitted light below the sample in a path different from a path for the illumination optical system, the transmitted light resulting from the illumination light that has been emitted from the illumination optical system, that has been reflected above the sample, and that has passed through the sample. The objective optical system includes, in the vicinity of a pupil plane, a pupil modulation element that partially decreases transmittance and that modulates the phase of light, and the illumination optical system includes a light source, and an illumination-region restricting section configured to restrict light from the light source to a particular emission region.
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