公开(公告)号：US10919979B2

公开(公告)日：2021-02-16

申请号：US15664425

申请日：2017-07-31

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K39/395 ,  C12N5/09 ,  A61K51/10 ,  A61K47/68 ,  A61K45/06 ,  A61N5/10 ,  C12N15/86 ,  C12N15/66 ,  C12N15/62 ,  C12N5/10

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US11350965B2

公开(公告)日：2022-06-07

申请号：US16459995

申请日：2019-07-02

Applicant: Ohio State Innovation Foundation

Inventor： Alper Yilmaz ,  Edward W. Martin ,  Stephen P. Povoski ,  Charles L. Hitchcock ,  Enver Ozer ,  Ronald Xu

IPC: A61B34/20 ,  A61B17/3211 ,  B25J9/16 ,  A61B34/30 ,  A61B34/00 ,  A61B5/06 ,  A61B6/12 ,  A61B6/00 ,  A61B10/04 ,  A61B17/00 ,  A61B90/11 ,  A61B90/00 ,  A61B90/50 ,  A61B5/00 ,  A61B5/055 ,  A61B6/03

Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.

公开(公告)号：US20190321065A1

公开(公告)日：2019-10-24

申请号：US16459995

申请日：2019-07-02

Applicant: Ohio State Innovation Foundation

Inventor： Alper Yilmaz ,  Edward W. Martin ,  Stephen P. Povoski ,  Charles L. Hitchcock ,  Enver Ozer ,  Ronald Xu

IPC: A61B17/3211 ,  A61B5/06 ,  B25J9/16 ,  A61B34/30 ,  A61B34/00 ,  A61B6/00 ,  A61B6/12 ,  A61B34/20

Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.

公开(公告)号：US09718888B2

公开(公告)日：2017-08-01

申请号：US14907368

申请日：2014-07-23

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K51/10 ,  C12N15/62 ,  C12N15/70 ,  C12N15/79 ,  C12N1/21 ,  C12N15/13 ,  A61K39/395 ,  G01N33/563 ,  G01N33/574 ,  G01N33/573 ,  G01N33/58 ,  C12N5/09 ,  A61K45/06 ,  A61K47/48 ,  A61N5/10 ,  C12N15/86 ,  C12N15/66 ,  C12N5/10

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US12268471B2

公开(公告)日：2025-04-08

申请号：US18639245

申请日：2024-04-18

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： James Coe ,  Heather Allen ,  Charles Hitchcock ,  Edward W. Martin

IPC: A61B5/00 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/552 ,  A61B17/00 ,  A61B90/00

Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate abnormal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.

公开(公告)号：US20180037663A1

公开(公告)日：2018-02-08

申请号：US15664425

申请日：2017-07-31

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K45/06 ,  A61K51/10 ,  C12N5/09 ,  A61K39/395 ,  A61N5/10 ,  C12N15/86 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US11986268B2

公开(公告)日：2024-05-21

申请号：US18139722

申请日：2023-04-26

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： James Coe ,  Heather Allen ,  Charles Hitchcock ,  Edward W. Martin

IPC: A61B5/00 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/552 ,  A61B17/00 ,  A61B90/00

CPC classification number: A61B5/0075 ,  A61B5/444 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/552 ,  A61B2017/00061 ,  A61B2090/373 ,  A61B2505/05 ,  A61B2576/00 ,  G01J2003/425

Abstract: Disclosed are systems and methods utilizing an infrared probe and discriminating software to rapidly discriminate abnormal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.

公开(公告)号：US11678802B2

公开(公告)日：2023-06-20

申请号：US16085210

申请日：2017-03-16

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： James Coe ,  Heather Allen ,  Charles Hitchcock ,  Edward W. Martin

IPC: A61B5/00 ,  G01N21/552 ,  G01N21/3563 ,  G01J3/42 ,  A61B90/00 ,  A61B17/00

CPC classification number: A61B5/0075 ,  A61B5/444 ,  G01J3/42 ,  G01N21/3563 ,  G01N21/552 ,  A61B2017/00061 ,  A61B2090/373 ,  A61B2505/05 ,  A61B2576/00 ,  G01J2003/425

Abstract: Systems and methods utilize an infrared probe and discriminating software to rapidly discriminate normal tissue processes from normal tissue during surgery, physical examination of in-situ lesions, and in the assessment of biopsy and resected tissue specimens. Examples demonstrate discrimination of cancerous from noncancerous tissues. The discriminating software, i.e. the metrics, algorithms, calibrant spectra, and decision equations, allows tissue to be identified as abnormal or normal using a minimum of infrared (IR) wavelengths in order to be measured rapidly. The probe records IR metrics approximately 1000 times faster than current commercial instruments, i.e. on a timescale fast enough for clinical use. The probe uses a tunable mid-infrared laser with a small set of selected wavelengths that are optimized for detecting the chemical and molecular signatures of tissue specific lesions to include, but not limited to, cancer, preneoplasia, intracellular accumulations (e.g. steatosis), inflammation, and wound healing.

公开(公告)号：US10383654B2

公开(公告)日：2019-08-20

申请号：US14549258

申请日：2014-11-20

Applicant: Ohio State Innovation Foundation

Inventor： Alper Yilmaz ,  Edward W. Martin ,  Stephen P. Povoski ,  Charles L. Hitchcock ,  Enver Ozer ,  Ronald Xu

IPC: A61B6/12 ,  A61B17/3211 ,  B25J9/16 ,  A61B34/20 ,  A61B6/00 ,  A61B5/06 ,  A61B34/30 ,  A61B34/00 ,  A61B10/04 ,  A61B17/00 ,  A61B90/11 ,  A61B90/50 ,  A61B90/00 ,  A61B6/03 ,  A61B5/00 ,  A61B5/055

Abstract: Systems and methods are described for performing navigation-assisted medical procedures such as biopsies, surgeries and pathology procedures by obtaining location information of an item of interest located within at least a portion of a subject; sensing position information of a moveable device; determining a relative position of the moveable device to the item of interest using the location information of the item of interest and the position information of the moveable device; and providing feedback based on the relative position of the moveable device to the item of interest that can be used to change the relative position of the moveable device to the item of interest.

公开(公告)号：US20160176979A1

公开(公告)日：2016-06-23

申请号：US14907368

申请日：2014-07-23

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61N5/10 ,  A61K45/06 ,  A61K51/10 ,  A61K47/48

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

Abstract translation: 本文公开了与特异性结合肿瘤相关糖蛋白72（TAG-72）的唾液酸-Tn表位的单链抗体片段相关的方法和组合物。