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1.发明申请METHODS AND COMPOSITIONS RELATED TO SINGLE CHAIN ANTIBODY FRAGMENTS THAT BIND TO TUMOR-ASSOCIATED GLYCOPROTEIN 72 (TAG-72) 有权与抗肿瘤相关糖蛋白72（TAG-72）的单链抗体片段相关的方法和组合物公开(公告)号：US20160176979A1
公开(公告)日：2016-06-23
申请号：US14907368
申请日：2014-07-23
Applicant: Ohio State Innovation Foundation
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Heather C. Allen , Edward W. Martin , Charles L. Hitchcock , E. David Alten , Nicholas E. Long
CPC classification number: C07K16/3076 , A61K39/395 , A61K45/06 , A61K47/6851 , A61K51/1045 , A61N5/10 , C07K16/3092 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N5/0693 , C12N5/10 , C12N15/62 , C12N15/66 , C12N15/86 , C12N2800/00 , G01N2800/00
Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
Abstract translation: 本文公开了与特异性结合肿瘤相关糖蛋白72（TAG-72）的唾液酸-Tn表位的单链抗体片段相关的方法和组合物。
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公开(公告)号：US10919979B2
公开(公告)日：2021-02-16
申请号：US15664425
申请日：2017-07-31
Applicant: Ohio State Innovation Foundation
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Heather C. Allen , Edward W. Martin , Charles L. Hitchcock , E. David Alten , Nicholas E. Long
IPC: C07K16/30 , A61K39/395 , C12N5/09 , A61K51/10 , A61K47/68 , A61K45/06 , A61N5/10 , C12N15/86 , C12N15/66 , C12N15/62 , C12N5/10
Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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3.发明申请公开(公告)号：US20180037663A1
公开(公告)日：2018-02-08
申请号：US15664425
申请日：2017-07-31
Applicant: Ohio State Innovation Foundation
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Heather C. Allen , Edward W. Martin , Charles L. Hitchcock , E. David Alten , Nicholas E. Long
IPC: C07K16/30 , A61K45/06 , A61K51/10 , C12N5/09 , A61K39/395 , A61N5/10 , C12N15/86 , C12N5/10 , C12N15/62 , C12N15/66
CPC classification number: C07K16/3076 , A61K39/395 , A61K45/06 , A61K47/6851 , A61K51/1045 , A61N5/10 , C07K16/3092 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N5/0693 , C12N5/10 , C12N15/62 , C12N15/66 , C12N15/86 , C12N2800/00 , G01N2800/00
Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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Patent Agency Ranking
公开(公告)号：US11787872B2
公开(公告)日：2023-10-17
申请号：US16694052
申请日：2019-11-25
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Nicholas E. Long
IPC: C07K16/30 , A61K51/10 , A61K39/395 , G01N33/574 , A61K47/60 , A61K39/00
CPC classification number: C07K16/3092 , A61K39/39558 , A61K39/39591 , A61K47/60 , A61K51/1045 , A61K51/1093 , G01N33/57492 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N2333/4728
Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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5.发明申请公开(公告)号：US20200255538A1
公开(公告)日：2020-08-13
申请号：US16694052
申请日：2019-11-25
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Nicholas E. Long
IPC: C07K16/30 , A61K51/10 , G01N33/574 , A61K39/395 , A61K47/60
Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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6.发明公开公开(公告)号：US20240166762A1
公开(公告)日：2024-05-23
申请号：US18447109
申请日：2023-08-09
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Nicholas E. Long
IPC: C07K16/30 , A61K39/395 , A61K47/60 , A61K51/10 , G01N33/574
CPC classification number: C07K16/3092 , A61K39/39558 , A61K39/39591 , A61K47/60 , A61K51/1045 , A61K51/1093 , G01N33/57492 , A61K2039/505
Abstract: Antibodies recognizing TAG-72 provide a novel approach for the imaging, detection, and treatment of cancer. These methods are made possible by using antibody fragments that bind specifically to the sialyl-Tn surface adhesin of TAG-72. Antibody fragment derivatives are advantageously useful over other antibody and antibody fragments known in the art because they are easy to express in large quantities, can penetrate tissues easily and lack the constant domains that promote often unwanted and usually superfluous effector functions.
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7.发明申请公开(公告)号：US20170218081A1
公开(公告)日：2017-08-03
申请号：US15328222
申请日：2015-07-23
Applicant: OHIO STATE INNOVATION FOUNDATION
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Nicholas E. Long
IPC: C07K16/30 , A61K39/395 , A61K51/10
CPC classification number: C07K16/3092 , A61K39/39558 , A61K39/39591 , A61K47/60 , A61K51/1045 , A61K51/1093 , A61K2039/505 , C07K2317/14 , C07K2317/24 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/57492 , G01N2333/4728
Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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公开(公告)号：US09718888B2
公开(公告)日：2017-08-01
申请号：US14907368
申请日：2014-07-23
Applicant: Ohio State Innovation Foundation
Inventor： Thomas J. Magliery , Brandon J. Sullivan , Heather C. Allen , Edward W. Martin , Charles L. Hitchcock , E. David Alten , Nicholas E. Long
IPC: C07K16/30 , A61K51/10 , C12N15/62 , C12N15/70 , C12N15/79 , C12N1/21 , C12N15/13 , A61K39/395 , G01N33/563 , G01N33/574 , G01N33/573 , G01N33/58 , C12N5/09 , A61K45/06 , A61K47/48 , A61N5/10 , C12N15/86 , C12N15/66 , C12N5/10
CPC classification number: C07K16/3076 , A61K39/395 , A61K45/06 , A61K47/6851 , A61K51/1045 , A61N5/10 , C07K16/3092 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C12N5/0693 , C12N5/10 , C12N15/62 , C12N15/66 , C12N15/86 , C12N2800/00 , G01N2800/00
Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).
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