公开(公告)号：US5407671A

公开(公告)日：1995-04-18

申请号：US983613

申请日：1992-11-30

Applicant: Norbert Heimburger ,  Peter Fuhge ,  Hansjorg Ronneberger

Inventor： Norbert Heimburger ,  Peter Fuhge ,  Hansjorg Ronneberger

IPC: A61L24/00 ,  A61K38/43 ,  A61K38/48 ,  A61K38/55 ,  A61L24/10 ,  A61P17/00 ,  A61P43/00 ,  A61K37/54 ,  A61K37/02

CPC classification number: A61L24/106 ,  Y10S514/802 ,  Y10S514/822

Abstract: A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof.This adhesive can be reconstituted from a freeze-dried form with water. It can contain all active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.

Abstract translation: 给出了在水溶液中含有纤维蛋白原，F XIII，凝血酶抑制剂，凝血酶原因子，钙离子以及在适当时含有纤溶酶抑制剂及其生产方法的单组分组织粘合剂的描述。 该粘合剂可以用冷冻干燥形式用水重构。 它可以包含巴氏灭菌形式的所有活性物质，然后没有传播肝炎和HTLV III的风险。

公开(公告)号：US06500427B1

公开(公告)日：2002-12-31

申请号：US08326254

申请日：1994-10-20

Applicant: Norbert Heimburger ,  Peter Fuhge ,  Hansjörg Ronneberger

Inventor： Norbert Heimburger ,  Peter Fuhge ,  Hansjörg Ronneberger

IPC: A61K3848

CPC classification number: A61L24/106 ,  Y10S514/802 ,  Y10S514/822

Abstract: A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof. This adhesive can be reconstituted from a freeze-dried form with water. It can contain aLL active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.

Abstract translation: 给出了在水溶液中含有纤维蛋白原，F XIII，凝血酶抑制剂，凝血酶原因子，钙离子和适当时含有纤溶酶抑制剂及其生产方法的单组分组织粘合剂的描述。该粘合剂 可以用冷冻干燥形式用水重构。 它可以含有一种以巴氏灭菌形式存在的活性物质，然后没有传播肝炎和HTLV III的风险。

公开(公告)号：US4960757A

公开(公告)日：1990-10-02

申请号：US227481

申请日：1988-08-01

Applicant: Gerhardt Kumpe ,  Wilfried Wormsbacher ,  Norbert Heimburger ,  Peter Fuhge ,  Hans M. Preis

Inventor： Gerhardt Kumpe ,  Wilfried Wormsbacher ,  Norbert Heimburger ,  Peter Fuhge ,  Hans M. Preis

IPC: A61K38/16 ,  A61K38/36 ,  A61K38/48 ,  A61L2/00

CPC classification number: A61L2/0023 ,  A61K38/363 ,  Y10S514/802 ,  Y10S514/97

Abstract: A pasteurized human firbinogen which can be used therapeutically, and a process for its preparation are described.

Abstract translation: 本发明描述了一种可以治疗的巴氏灭菌的人类凝血因子及其制备方法。

公开(公告)号：US4650678A

公开(公告)日：1987-03-17

申请号：US639617

申请日：1984-08-10

Applicant: Peter Fuhge ,  Norbert Heimburger ,  Hans-Arnold Stohr ,  Wolfgang Burk

Inventor： Peter Fuhge ,  Norbert Heimburger ,  Hans-Arnold Stohr ,  Wolfgang Burk

IPC: A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  A61K38/43 ,  A61K47/16 ,  A61L24/10 ,  C07K14/75 ,  A61K31/155 ,  A61K31/17 ,  A61K31/195

CPC classification number: A61L24/106 ,  C07K14/75 ,  A61K38/00

Abstract: A solid fibrinogen formulation is described, which formulation contains, in addition to fibrinogen, a substance containing the urea or guanidine radical, and a process for its preparation. This formulation is used for the preparation of a fibrinogen solution which is suitable as an adhesive for human and animal tissue and as a fibrinogen concentrate for intravenous administration.

Abstract translation: 描述了一种固体纤维蛋白原制剂，该制剂除纤维蛋白原外还含有含有尿素或胍基的物质及其制备方法。 该制剂用于制备纤维蛋白原溶液，其适合作为人和动物组织的粘合剂以及用于静脉内施用的纤维蛋白原浓缩物。

公开(公告)号：US4510126A

公开(公告)日：1985-04-09

申请号：US430748

申请日：1982-09-30

Applicant: Peter Fuhge ,  Konrad Braun ,  Udo Becker

Inventor： Peter Fuhge ,  Konrad Braun ,  Udo Becker

IPC: G01N33/50 ,  C12Q1/56 ,  G01N33/86 ,  G01N1/00 ,  G01N1/30 ,  G01N33/48

CPC classification number: G01N33/86 ,  C12Q1/56 ,  G01N2333/755 ,  Y10T436/101666

Abstract: An agent for determining ristocetin cofactor (v.Willebrand factor) is described, which contains platelets which have been treated with a tanning agent, with a protease inhibitor and, optionally, with a dye-stuff, and ristocetin A.

Abstract translation: 描述了一种用于测定瑞斯托菌素辅因子（v.Willebrand因子）的试剂，其包含已经用鞣剂处理的血小板，具有蛋白酶抑制剂，任选地含有染料和瑞斯他汀A.

公开(公告)号：US4621631A

公开(公告)日：1986-11-11

申请号：US564917

申请日：1983-12-23

Applicant: Eric P. Paques ,  Peter Fuhge

Inventor： Eric P. Paques ,  Peter Fuhge

IPC: A61L15/16 ,  A61L15/20 ,  A61L15/32 ,  C08J5/18 ,  C09H3/00 ,  C09H7/00 ,  A61F13/00

CPC classification number: C09H7/00 ,  A61L15/20 ,  A61L15/325 ,  C09H3/00 ,  Y10S128/08 ,  Y10S514/801

Abstract: A process for the production of an unnative and biologically active bonded collagen fiber sheet from human placentae is described, in which process collagen-containing material from placentae is treated with a neutral salt solution, a solution of citric acid and with pepsin. The degraded collagen material obtained in this manner is, where appropriate, treated with a crosslinking agent. The collagen material produced in this manner is used for producing bonded collagen fiber sheets which can be used, for example, as covering for wounds.

Abstract translation: 描述了从人胎盘生产不需要的和生物活性的粘合的胶原纤维片的方法，其中使用中性盐溶液，柠檬酸溶液和胃蛋白酶处理来自胎盘的含胶原物质。 以这种方式获得的降解胶原材料在适当的情况下用交联剂处理。 以这种方式制造的胶原材料用于生产可用于例如伤口覆盖物的粘合胶原纤维片。