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公开(公告)号：US5407671A
公开(公告)日：1995-04-18
申请号：US983613
申请日：1992-11-30
Applicant: Norbert Heimburger , Peter Fuhge , Hansjorg Ronneberger
Inventor： Norbert Heimburger , Peter Fuhge , Hansjorg Ronneberger
IPC: A61L24/00 , A61K38/43 , A61K38/48 , A61K38/55 , A61L24/10 , A61P17/00 , A61P43/00 , A61K37/54 , A61K37/02
CPC classification number: A61L24/106 , Y10S514/802 , Y10S514/822
Abstract: A description is given of a one-component tissue adhesive containing, in aqueous solution, fibrinogen, F XIII, a thrombin inhibitor, prothrombin factors, calcium ions and, where appropriate, a plasmin inhibitor and of a process for the production thereof.This adhesive can be reconstituted from a freeze-dried form with water. It can contain all active substances in pasteurized form and is then free of the risk of transmission of hepatitis and HTLV III.
Abstract translation: 给出了在水溶液中含有纤维蛋白原，F XIII，凝血酶抑制剂，凝血酶原因子，钙离子以及在适当时含有纤溶酶抑制剂及其生产方法的单组分组织粘合剂的描述。 该粘合剂可以用冷冻干燥形式用水重构。 它可以包含巴氏灭菌形式的所有活性物质，然后没有传播肝炎和HTLV III的风险。
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2.发明授权Process for the purification of the blood clotting factors, II, VII, IX and/or X 失效纯化血液凝固因子II，VII，IX和/或X的方法
公开(公告)号：US4411794A
公开(公告)日：1983-10-25
申请号：US340896
申请日：1982-01-19
Applicant: Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Heinz H. Drescher
Inventor： Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Heinz H. Drescher
IPC: C07K14/745 , A61K35/14 , A61K38/00 , A61K38/16 , A61K38/43 , C07K14/435 , C12N9/64 , C12N9/74 , B01D15/00
CPC classification number: C12N9/647 , C12N9/6429 , C12Y304/21005 , A61K38/00
Abstract: A process for purifying liquids containing blood clotting factors by adsorption of the factors on mineral adsorbents such as calcium phosphate, aluminum hydroxide gel, barium sulfate or hydroxylapatite in the presence of calcium ions followed by elution is described.
Abstract translation: 描述了在钙离子存在下，通过在矿物质吸附剂如磷酸钙，氢氧化铝凝胶，硫酸钡或羟基磷灰石上吸附因素来纯化含有凝血因子的液体的方法，然后洗脱。
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公开(公告)号：US4178329A
公开(公告)日：1979-12-11
申请号：US902901
申请日：1978-05-05
Applicant: Udo Becker , Karlheinz Burg , Johann P. Fischer , Norbert Heimburger
Inventor： Udo Becker , Karlheinz Burg , Johann P. Fischer , Norbert Heimburger
IPC: C08F291/00 , A61L33/00 , A61L33/06 , C08F8/12 , C08F255/00 , C08F255/02
CPC classification number: C08F255/00 , A61L33/064 , C08F8/12
Abstract: What is disclosed is a plastics material adaptable to biomedical uses, the surface of which material at least partially consists of a graft copolymer having a hydrocarbon main chain and side chains grafted thereon, said side chains being polymers comprising at least one vinyl monomer selected from the group consisting of acrylic acid esters of the formulaCF.sub.3 --(CF.sub.2).sub.x --(CH.sub.2).sub.y --O--CO--CH.dbd.CH.sub.2,where x is an integer from 3 to 16 and y is an integer from 1 to 12, vinylene carbonate, N-vinyl alkylamides of the formula ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is hydrogen or alkyl having 1 to 6 carbon atoms.
Abstract translation: 公开的是适用于生物医学用途的塑料材料，其表面至少部分地由具有烃主链和其上接枝的侧链的接枝共聚物组成，所述侧链是包含至少一种乙烯基单体的聚合物，所述乙烯基单体选自 由CF 3 - （CF 2）x - （CH 2）y O-CO-CH = CH 2的丙烯酸酯组成的组，其中x是3至16的整数，y是1至12的整数，碳酸亚乙烯酯，N 乙烯基烷基酰胺，其中R 1和R 2相同或不同，各自为氢或具有1至6个碳原子的烷基。
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4.发明授权Pasteurized, purified von Willebrand factor concentrate and a process for the preparation thereof 失效巴氏灭菌纯化的维伦布兰德因子浓缩物及其制备方法公开(公告)号：US06239261B1
公开(公告)日：2001-05-29
申请号：US08253232
申请日：1994-06-02
Applicant: Norbert Heimburger , Gerhard Kumpe , Klaus Wellner
Inventor： Norbert Heimburger , Gerhard Kumpe , Klaus Wellner
IPC: C07K100
CPC classification number: C07K14/755
Abstract: A process for the preparation of a concentrate of von Willebrand factor is described, entailing a solution of a complex of this factor with factor VIII:C being optionally pasteurized and treated with an anion exchanger, there being no binding of the von Willebrand factor.
Abstract translation: 描述了制备冯维勒布兰德因子浓缩物的方法，其中涉及该因子与因子VIII的复合物的溶液：C任选被巴氏杀菌并用阴离子交换剂处理，不存在von Willebrand因子的结合。
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5.发明授权Method for the determination of the plasminogen activator activity in samples containing alpha-2-antiplasmin 失效用于测定含有α-2-抗血浆素的样品中纤溶酶原激活物活性的方法
公开(公告)号：US5607837A
公开(公告)日：1997-03-04
申请号：US96843
申请日：1993-07-26
Applicant: Thomas Stief , Norbert Heimburger
Inventor： Thomas Stief , Norbert Heimburger
CPC classification number: C12Q1/56 , G01N33/86 , C12Q2337/12 , G01N2333/81 , G01N2333/968
Abstract: The disclosed invention provides a method for determining the plasminogen activator (PA) activity in a biological fluid. The method involves the use of proteolytically-degraded plasminogen and effectively eliminates the influence of alpha-2-antiplasmin on the determination of PA activity.
Abstract translation: 所公开的发明提供了用于测定生物流体中的纤溶酶原激活物（PA）活性的方法。 该方法包括使用蛋白水解降解的纤溶酶原，有效消除了α-2-抗血纤蛋白对PA活性测定的影响。
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Patent Agency Ranking
公开(公告)号：US5512449A
公开(公告)日：1996-04-30
申请号：US352683
申请日：1994-11-30
Applicant: Thomas Stief , Norbert Heimburger , Klaus-Peter Radtke
Inventor： Thomas Stief , Norbert Heimburger , Klaus-Peter Radtke
CPC classification number: C12Q1/56 , G01N2333/75 , G01N2333/96461 , G01N2333/9723 , G01N2400/40
Abstract: A method and an agent for the functional determination of protein C inhibitor in body fluids are described, in which this fluid is incubated with a known amount of a plasminogen activator, fibrinogen and a sulfated carbohydrate, and the residual activity of the plasminogen activator is determined, and from this the amount of protein C inhibitor is determined.
Abstract translation: 描述了用于体液中蛋白C抑制剂的功能测定的方法和试剂，其中将该流体与已知量的纤溶酶原激活剂，纤维蛋白原和硫酸化碳水化合物一起温育，并测定纤溶酶原激活物的残留活性 ，并从中测定蛋白C抑制剂的量。
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7.发明授权Process for the pasteurization of antihemophilic cryoprecipitate (AHC) and antihemophilic cryoprecipitate prepared thereby 失效由此制备的抗血友病性低温沉淀物（AHC）和抗血友病性冷沉淀物的巴氏消毒法
公开(公告)号：US4562072A
公开(公告)日：1985-12-31
申请号：US540172
申请日：1983-10-07
Applicant: Norbert Heimburger , Gerhardt Kumpe , Wilfried Wormsbacher , Hans M. Preis
Inventor： Norbert Heimburger , Gerhardt Kumpe , Wilfried Wormsbacher , Hans M. Preis
CPC classification number: A61K38/37 , A61L2/0023
Abstract: A process for the pasteurization of antihemophilic cryoprecipitate (AHC) is described, wherein AHC is heated in the presence of calicum ions, an amino acid and a carbohydrate. The pasteurized AHC is used for the treatment of coagulation disturbances.
Abstract translation: 描述了用于巴氏杀菌抗血液冷沉淀物（AHC）的方法，其中在存在calicum离子，氨基酸和碳水化合物的情况下加热AHC。 巴氏灭菌AHC用于治疗凝血障碍。
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8.发明授权
公开(公告)号：US4442213A
公开(公告)日：1984-04-10
申请号：US377312
申请日：1982-05-12
Applicant: Helmut Heber , Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Manfred Schick
Inventor： Helmut Heber , Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Manfred Schick
CPC classification number: C12N9/6435 , A61K38/484 , C12Y304/21007
Abstract: What is disclosed is a process for rendering plasminogen virtually free of hepatitis virus by heating a plasminogen solution in the presence of a proteinase inhibitor with plasmin specificity, an amino acid, and a saccharide or sugar alcohol.
Abstract translation: 公开的是通过在蛋白酶抑制剂与纤溶酶特异性，氨基酸和糖或糖醇的存在下加热纤溶酶原溶液来实质上不含肝炎病毒的纤溶酶原的方法。
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9.发明授权
公开(公告)号：US4405603A
公开(公告)日：1983-09-20
申请号：US324872
申请日：1981-11-25
Applicant: Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Wilfried Wormsbacher
Inventor： Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Wilfried Wormsbacher
CPC classification number: C12N9/647 , A61L2/0023 , A61K38/00
Abstract: What is disclosed is a method for making a preparation containing blood clotting Factors IX and/or X virtually hepatitis-safe by warming said peparation in the presence of calcium ions and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
Abstract translation: 所公开的方法是通过在钙离子的存在下加热所述分离物以及在氨基酸和/或糖或糖醇的进一步存在下制备含有凝血因子IX和/或X的制剂的实质上具有肝炎安全性的方法 。
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10.发明授权Method for rendering factors II and VII hepatitis-safe with a chelating agent 失效用螯合剂使II型和VII型肝炎安全的方法
公开(公告)号：US4404187A
公开(公告)日：1983-09-13
申请号：US323116
申请日：1981-11-19
Applicant: Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Hans M. Preis
Inventor： Horst Schwinn , Norbert Heimburger , Gerhardt Kumpe , Hans M. Preis
IPC: C07K14/745 , A61K38/00 , A61K38/43 , A61L2/00 , C07K14/435 , C12N9/64 , A61K35/14
CPC classification number: C12N9/6437 , A61L2/0023 , C12Y304/21021 , A61K38/00
Abstract: What is disclosed is a method for treating a preparation containing blood clotting Factors II and/or VII to render it virtually hepatitis-free by warming said preparation in the presence of a chelating agent and in the further presence of an amino acid and/or a saccharide or sugar alcohol.
Abstract translation: 所公开的是一种治疗含有血液凝固因子II和/或VII的制剂的方法，通过在螯合剂存在下加热所述制剂并使氨基酸和/或 糖或糖醇。
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