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    Process for preparing fat soluble beadlets
    1.
    发明授权
    Process for preparing fat soluble beadlets 有权
    制备脂溶性珠粒的方法

    公开(公告)号：US06444227B1

    公开(公告)日：2002-09-03

    申请号：US09626976

    申请日：2000-07-27

    Applicant: Bruno Leuenberger ,  Jean-Claude Tritsch ,  Johann Ulm

    Inventor： Bruno Leuenberger ,  Jean-Claude Tritsch ,  Johann Ulm

    IPC: A61K914

    CPC classification number: C09H7/00 ,  A61K9/1658 ,  A61K9/5036

    Abstract: The invention relates to a process for preparing beadlets containing fat soluble substances in a gelatin matrix which comprises crosslinking the gelatin by radiation or enzymatically. Specifically, the invention relates to a process for preparing beadlets containing fat soluble substances having the steps of: (1) forming an aqueous emulsion of a fat soluble substance, a gelatin, a reducing agent; (2) converting the emulsion into a dry powder; and (3) crosslinking the gelatin matrix in the coated particles by exposing the coated particles to radiation or, in the case of a crosslinking enzyme being present, by incubating the coated particles.

    Abstract translation: 本发明涉及一种制备在明胶基质中含有脂溶性物质的珠粒的方法，其包括通过辐射或酶促交联明胶。 具体而言，本发明涉及一种制备含有脂溶性物质的珠粒的方法，其特征在于：（1）形成脂溶性物质，明胶，还原剂的水性乳液;（2）将乳液转变为干粉 ; 和（3）通过将包被的颗粒暴露于辐射或在存在交联酶的情况下通过温育涂覆的颗粒来使包衣颗粒中的明胶基质交联。

    Transparent non-fibrilized collagen material by ultracentrifugation
    2.
    发明授权
    Transparent non-fibrilized collagen material by ultracentrifugation 失效
    透明非纤维化胶原材料通过超速离心

    公开(公告)号：US4505855A

    公开(公告)日：1985-03-19

    申请号：US431578

    申请日：1982-09-30

    Applicant: Romaine R. Bruns ,  Jerome Gross

    Inventor： Romaine R. Bruns ,  Jerome Gross

    IPC: A61F2/00 ,  A61F2/14 ,  A61L27/24 ,  C09H7/00 ,  C07G7/00 ,  A61B19/00 ,  A61F1/16

    CPC classification number: C09H7/00 ,  A61F2/14 ,  A61F2/142 ,  A61L27/24 ,  A61F2310/00365 ,  Y10S128/08 ,  Y10S530/84 ,  Y10S530/842

    Abstract: A transparent native, non-fibrilized collagen material is described having an absorbence at a wavelength of 900 nm of less than 5% in a sample 5 mm thick. This collagen material is useful for a prosthetic replacement of the cornea because of the high transparency and because it is a native material, and thus less susceptible to immunogenic responses. A method for forming the native, non-fibrilized, highly transparent collagen material comprises ultracentrifuging a purified solution of native collagen to form a pellet of transparent collagen material, and fixing the pellet of collagen material to form a rigid, leather-like material. The collagen material can also be used for prosthetic replacement of other bodily tissues, such as nucleus pulposus, cartilage, and vitreous body.

    Abstract translation: 描述了在5mm厚的样品中具有在900nm波长下的吸光度小于5％的透明天然的非纤维化胶原材料。 这种胶原材料因为高透明度而且因为它是天然材料，因此对免疫原性反应较不敏感，因此可用于角膜的假体置换。 用于形成天然的，非纤维化的，高度透明的胶原材料的方法包括将纯化的天然胶原溶液进行超速离心以形成透明胶原材料的颗粒，并将胶原材料的颗粒固定以形成刚性的皮革样材料。 胶原材料也可以用于其他身体组织的替代物，例如髓核，软骨和玻璃体。

    Hardening proteinaceous materials
    3.
    发明授权
    Hardening proteinaceous materials 失效
    硬化蛋白质材料

    公开(公告)号：US4187114A

    公开(公告)日：1980-02-05

    申请号：US904278

    申请日：1978-05-09

    Applicant: Hendrik E. Kokelenberg ,  Francis J. Sels ,  George F. Van Veelen

    Inventor： Hendrik E. Kokelenberg ,  Francis J. Sels ,  George F. Van Veelen

    IPC: C08H1/00 ,  C08K5/3492 ,  C09H7/00 ,  G03C1/30

    CPC classification number: G03C1/30 ,  C08K5/3492 ,  C09H7/00

    Abstract: Proteinaceous material such as gelatin is hardened by treatment with an aqueous solution of the partial hydrolysis product of a 2,4-dichloro-6-alkoxy-S-triazine with a water-soluble tertiary phosphate and/or a water-soluble borate, wherein the 2,4-dichloro-6-alkoxy-s-triazine corresponds to the formula: ##STR1## wherein R is a lower alkyl or alkoxyalkyl group. The proteinaceous material can be a proteinaceous coating such as a photographic silver halide emulsion layer, a backing layer, a protective layer, a filter layer, or any other photographic auxiliary layer.

    Abstract translation: 通过用2,4-二氯-6-烷氧基-S-三嗪与水溶性叔磷酸盐和/或水溶性硼酸盐的部分水解产物的水溶液进行处理来使诸如明胶的蛋白质物质硬化，其中 2,4-二氯-6-烷氧基-s-三嗪对应于下式：其中R是低级烷基或烷氧基烷基。 蛋白质材料可以是蛋白质涂层，例如照相卤化银乳剂层，背衬层，保护层，过滤层或任何其它照相辅助层。

    Synthesis of cross-links in the helical domain of collagen using pyridoxal 5-phosphate and copper or iron
    9.
    发明授权
    Synthesis of cross-links in the helical domain of collagen using pyridoxal 5-phosphate and copper or iron 失效
    使用吡哆醛5-磷酸和铜或铁合成胶原螺旋结构域中的交联

    公开(公告)号：US4544638A

    公开(公告)日：1985-10-01

    申请号：US611909

    申请日：1984-05-18

    Applicant: Robert C. Siegel

    Inventor： Robert C. Siegel

    IPC: C08H1/06 ,  C09H7/00 ,  C08L89/06

    CPC classification number: C09H7/00 ,  C08H1/06

    Abstract: Aldehyde cross-link intermediates and cross-links are generated in the central helical portion of collagen by incubating collagen with pyridoxal-5-phosphate and either cupric copper ion or ferrous iron ion. The cross-links are chemically similar to natural cross-links found in the non-helical regions and are directly between amino-acid moieties naturally occuring in the central helical portion of collagen. Cross-linking and utilization of aldehyde intermediates occurs when the product is reincubated after pyridoxal is removed. Alternatively maintaining the product at body temperatures will promote cross-linking. The cross-linked collagen product has increased resistance to enzyme degradation.

    Abstract translation: 通过将胶原蛋白与吡哆醛-5-磷酸盐和铜离子或亚铁离子孵育，在胶原的中心螺旋部分中产生醛交联中间体和交联。 交联在化学上类似于在非螺旋区域中发现的天然交联，并且直接位于天然存在于胶原中心螺旋部分的氨基酸部分之间。 醛类中间体的交联和利用发生在产物在除去吡哆醛后重新培养。 或者将产品保持在体温将促进交联。 交联胶原蛋白产品具有增加的抗酶降解能力。

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