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1.发明授权公开(公告)号：US11155823B2
公开(公告)日：2021-10-26
申请号：US15735028
申请日：2016-06-15
IPC分类号： C12N15/70 , C12N15/10 , C12P19/34 , A01N63/40 , A61P31/04 , C12N7/00 , C12N9/10 , C12N9/22 , C12N9/96 , C12N15/11 , A61K38/00
摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
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2.发明申请公开(公告)号：US20210403926A1
公开(公告)日：2021-12-30
申请号：US17471776
申请日：2021-09-10
IPC分类号： C12N15/70 , C12N15/10 , C12P19/34 , A01N63/40 , A61P31/04 , C12N7/00 , C12N9/10 , C12N9/22 , C12N9/96 , C12N15/11
摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
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3.发明授权公开(公告)号：US11439712B2
公开(公告)日：2022-09-13
申请号：US15302655
申请日：2015-04-07
发明人： Chase Beisel , Michelle Luo
摘要： The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.
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4.发明申请公开(公告)号：US20180155729A1
公开(公告)日：2018-06-07
申请号：US15735028
申请日：2016-06-15
IPC分类号： C12N15/70 , A01N63/00 , C12N9/10 , C12N15/10 , C12N7/00 , C12N15/11 , C12N9/22 , C12N9/96 , A61P31/04
CPC分类号： C12N15/70 , A01N63/00 , A61K38/00 , A61P31/04 , C12N7/00 , C12N9/1007 , C12N9/22 , C12N9/96 , C12N15/102 , C12N15/11 , C12N2310/20 , C12N2795/10143 , C12N2795/14143 , C12P19/34 , Y02A50/481
摘要： The invention relates to the methods for modifying the methylation pattern of bacteriophage DNA and phagemid DNA and to methods for selective killing of bacteria using lysogenic bacteriophages comprising bacteriophage DNA or phagemid DNA comprising components of an engineered CRISPR-Cas system.
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5.发明申请Methods and Compositions for RNA-Directed Repression of Transcription Using CRISPR-Associated Genes 审中-公开使用CRISPR相关基因的RNA定向抑制转录的方法和组合公开(公告)号：US20170028083A1
公开(公告)日：2017-02-02
申请号：US15302655
申请日：2015-04-07
发明人： Chase Beisel , Michelle Luo
CPC分类号： A61K48/005 , C12N9/22 , C12N15/102 , C12N15/111 , C12N15/63 , C12N15/72 , C12N2310/20 , C12N2320/30
摘要： The present invention is directed to methods and compositions for targeted gene silencing that provide the ability to not only repress expression but to modulate the repression of expression of one or more target genes. In one aspect, a recombinant nucleic acid molecule is provided comprising a nucleotide sequence encoding a subset of CRISPR-cas polypeptides, or functional fragments thereof, from a type-I CRISPR-cas system. In some aspects, a recombinant nucleic acid of the invention comprises a nucleotide sequence encoding three or more Type I Cascade polypeptides having substantial identity to a type I Cascade polypeptide.
摘要翻译： 本发明涉及用于靶向基因沉默的方法和组合物，其提供不仅抑制表达但调节一种或多种靶基因表达的抑制的能力。 一方面，提供重组核酸分子，其包含编码来自I型CRISPR-cas系统的CRISPR-cas多肽或其功能片段的子集的核苷酸序列。 在一些方面，本发明的重组核酸包含编码与I型级联多肽具有实质同一性的三种或更多种I型级联多肽的核苷酸序列。
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