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公开(公告)号：US20180051246A1
公开(公告)日：2018-02-22
申请号：US15678643
申请日：2017-08-16
Applicant: Morgan State University
Inventor： Viji Sitther , Kadir Aslan
CPC classification number: C12N1/38 , C10L1/02 , C10L2200/0469 , C10L2290/26 , C12N1/12 , C12N1/20 , C12P7/64 , C12P7/6445 , C12P9/00 , C12P23/00 , C12P33/00
Abstract: Compositions including metal nano- and/or micro-particles in solution with photosynthetic bioproduct producing microorganisms. These light harvesting complexes increase growth rates and photosynthetic efficiency of the constituent microorganisms, reducing the light required for a specific production level, or increases production for a specific light level.
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公开(公告)号：US10894084B2
公开(公告)日：2021-01-19
申请号：US15356984
申请日：2016-11-21
Applicant: Morgan State University
Inventor： Kadir Aslan
Abstract: In this study, we demonstrated a unique application of our Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the de-crystallization of uric acid crystals, which causes gout in humans when monosodium urate crystals accumulate in the synovial fluid found in the joints of bones. Given the shortcomings of the existing treatments for gout, we investigated whether the MAMAD technique can offer an alternative solution to the treatment of gout. Our technique is based on the use of metal nanoparticles (i.e., gold colloids) with low microwave heating to accelerate the de-crystallization process. In this regard, we employed a two-step process; (i) crystallization of uric acid on glass slides, which act as a solid platform to mimic a bone, (ii) de-crystallization of uric acid crystals on glass slides with the addition of gold colloids and low power microwave heating, which act as “nano-bullets” when microwave heated in a solution. We observed that the size and number of the uric acid crystals were reduced by >60% within 10 minutes of low power microwave heating. In addition, the use of gold colloids without microwave heating (i.e. control experiment) did not result in the de-crystallization of the uric acid crystals, which proves the utility of our MAMAD technique in the de-crystallization of uric acid.
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Patent Agency Ranking
公开(公告)号：US11967064B2
公开(公告)日：2024-04-23
申请号：US17204194
申请日：2021-03-17
Applicant: Morgan State University
Inventor： Edward Constance , Kadir Aslan , Enock Bonyi
CPC classification number: G06T7/0012 , G01N21/31 , G06T7/90 , G06T2207/10024 , G06T2207/30072
Abstract: Systems and methods are provided for the rapid sensing of biological and environmental analytes employing a portable digital image capture device, such as a smartphone camera, to capture an image of colorimetric microwave-accelerated bioassays (“MAB”), and a digital image analyzer that processes the colorimetric signals captured by the digital camera to determine the concentration of analyte in a test sample based on a calculated pixel intensity in the captured digital image. Such systems and methods may be used to detect either a disease condition or the presence of a toxin in a particular test specimen and may generate an electronic alert that may serve to alert a medical practitioner of such disease condition or presence of a toxin so that medical intervention may be undertaken. Such electronic alert may optionally be transmitted to the user of a smartphone that captured the image, thus allowing for rapid, in-situ point-of-care analysis and detection of such conditions and immediate medical intervention.
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公开(公告)号：US09243017B2
公开(公告)日：2016-01-26
申请号：US13649561
申请日：2012-10-11
Applicant: Morgan State University
Inventor： Kadir Aslan
CPC classification number: C07H1/06 , C07B2200/13 , C07C227/42 , C30B7/005 , C30B28/06 , C30B29/58 , C07C229/08
Abstract: The present invention relates to methods for rapid crystallization of amino acids, drug molecules, proteins and DNA/peptides. One method for rapid crystallization of functional group-containing molecules selected from the group consisting of amino acids, drug molecules, proteins and DNA/peptides includes (A) providing at least one metal or metal oxide in particulate or thin film form to provide (a) selective nucleation sites for crystallization of the functional group-containing molecules due to interactions of their functional groups and metal surfaces or engineered metal surfaces and (b) a microwave-transparent medium to create a thermal gradient between the metal surfaces or engineered metal surfaces and a warmer solution containing functional group-containing molecules to be crystallized, and (B) conducting microwave heating to cause the functional group-containing molecules to be crystallized.
Abstract translation: 本发明涉及氨基酸，药物分子，蛋白质和DNA /肽快速结晶的方法。 选自氨基酸，药物分子，蛋白质和DNA /肽的含官能团分子的快速结晶的一种方法包括（A）提供至少一种颗粒或薄膜形式的金属或金属氧化物以提供（a ）由于其官能团和金属表面或工程金属表面的相互作用而使含官能团的分子结晶的选择性成核位点和（b）微波透明介质以在金属表面或工程金属表面之间产生热梯度，以及 含有待结晶的含有官能团的分子的较暖的溶液，（B）进行微波加热使含官能团的分子结晶。
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公开(公告)号：US11162067B2
公开(公告)日：2021-11-02
申请号：US15678643
申请日：2017-08-16
Applicant: Morgan State University
Inventor： Viji Sitther , Kadir Aslan , Behnam Tabatabai
Abstract: Compositions including metal nano- and/or micro-particles in solution with photosynthetic bioproduct producing microorganisms. These light harvesting complexes increase growth rates and photosynthetic efficiency of the constituent microorganisms, reducing the light required for a specific production level, or increases production for a specific light level.
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公开(公告)号：US20210295505A1
公开(公告)日：2021-09-23
申请号：US17204194
申请日：2021-03-17
Applicant: Morgan State University
Inventor： Edward Constance , Kadir Aslan , Enock Bonyi
Abstract: Systems and methods are provided for the rapid sensing of biological and environmental analytes employing a portable digital image capture device, such as a smartphone camera, to capture an image of colorimetric microwave-accelerated bioassays (“MAB”), and a digital image analyzer that processes the colorimetric signals captured by the digital camera to determine the concentration of analyte in a test sample based on a calculated pixel intensity in the captured digital image. Such systems and methods may be used to detect either a disease condition or the presence of a toxin in a particular test specimen and may generate an electronic alert that may serve to alert a medical practitioner of such disease condition or presence of a toxin so that medical intervention may be undertaken. Such electronic alert may optionally be transmitted to the user of a smartphone that captured the image, thus allowing for rapid, in-situ point-of-care analysis and detection of such conditions and immediate medical intervention.
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公开(公告)号：US20170143829A1
公开(公告)日：2017-05-25
申请号：US15356984
申请日：2016-11-21
Applicant: Morgan State University
Inventor： Kadir Aslan
CPC classification number: A61K41/0028 , A61K9/08 , A61K9/16 , A61K33/24 , A61N5/025
Abstract: In this study, we demonstrated a unique application of our Metal-Assisted and Microwave-Accelerated Decrystallization (MAMAD) technique for the de-crystallization of uric acid crystals, which causes gout in humans when monosodium urate crystals accumulate in the synovial fluid found in the joints of bones. Given the shortcomings of the existing treatments for gout, we investigated whether the MAMAD technique can offer an alternative solution to the treatment of gout. Our technique is based on the use of metal nanoparticles (i.e., gold colloids) with low microwave heating to accelerate the de-crystallization process. In this regard, we employed a two-step process; (i) crystallization of uric acid on glass slides, which act as a solid platform to mimic a bone, (ii) de-crystallization of uric acid crystals on glass slides with the addition of gold colloids and low power microwave heating, which act as “nano-bullets” when microwave heated in a solution. We observed that the size and number of the uric acid crystals were reduced by >60% within 10 minutes of low power microwave heating. In addition, the use of gold colloids without microwave heating (i.e. control experiment) did not result in the de-crystallization of the uric acid crystals, which proves the utility of our MAMAD technique in the de-crystallization of uric acid.
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