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12 条记录 (耗时 0.024 秒)

    Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
    2.
    发明授权
    Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents 有权
    制备含有药物活性剂的可生物降解的微粒制剂的方法

    公开(公告)号：US07758778B2

    公开(公告)日：2010-07-20

    申请号：US11220430

    申请日：2005-09-07

    申请人： Joseph T. Persyn ,  Joseph A. McDonough ,  Neal K. Vail ,  Darren E. Barlow ,  Albert M. Zwiener ,  Eliot M. Slovin

    发明人： Joseph T. Persyn ,  Joseph A. McDonough ,  Neal K. Vail ,  Darren E. Barlow ,  Albert M. Zwiener ,  Eliot M. Slovin

    IPC分类号： B29B9/00 ,  A61J3/00

    CPC分类号： B01J13/04 ,  A61K9/1682 ,  A61K9/5089

    摘要： This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

    摘要翻译： 本发明涉及一种用于生产包含药理活性剂和可生物降解聚合物的微粒的装置和方法。 该装置包括在其中心包含储存器的旋转盘和平坦的倾斜表面。 该装置可选地包括锯齿状和/或平行于盘的旋转轴线的圆周周围的平坦表面。 本发明还涉及使用旋转圆盘装置的含有药理活性剂的微粒的制造方法。 提供含有眼科活性剂的制剂。 还描述了显示零级释放速率的制剂。

    Encapsulated corn kernels and method of forming the same
    3.
    发明授权
    Encapsulated corn kernels and method of forming the same 失效
    封装的玉米粒及其形成方法

    公开(公告)号：US5132125A

    公开(公告)日：1992-07-21

    申请号：US675552

    申请日：1991-03-25

    申请人： Chel W. Lew ,  Darren E. Barlow

    发明人： Chel W. Lew ,  Darren E. Barlow

    IPC分类号： A23B7/00 ,  A23L1/18 ,  A23L1/182

    CPC分类号： A23B7/00 ,  A23L7/183 ,  A23L7/1963

    摘要： Encapsulated corn kernels consisting essentially of kernels of corn suitable for popping coated over at least a portion of the outer surface thereof with an edible oleaginous substance or edible wax and thereover with an outer shell comprising an edible polymeric material and an anti-fragility and palatability enhancer; the process of making such encapsulated kernel; and microwaveable pop corn products consisting essentially of the encapsulated corn kernels in a microwaveable package.

    摘要翻译： 基本上由玉米颗粒组成的包封的玉米粒含有可食用的含油物质或可食用的蜡，并且外壳包含可食用的聚合物材料和抗脆性和适口性增强剂，所述玉米粒适合于在其外表面的至少一部分上涂覆 ; 制作这种封装核的过程; 以及基本上由微波包装中包封的玉米粒组成的可微波的玉米制品。

    Layer by layer modification of microcapsules with inorganic materials
    4.
    发明授权
    Layer by layer modification of microcapsules with inorganic materials 有权
    用无机材料逐层改性微胶囊

    公开(公告)号：US08557382B2

    公开(公告)日：2013-10-15

    申请号：US12468571

    申请日：2009-05-19

    申请人： James D Oxley ,  Jenny J. Finkbiner ,  Darren E. Barlow

    发明人： James D Oxley ,  Jenny J. Finkbiner ,  Darren E. Barlow

    IPC分类号： C25D9/00 ,  A61K9/00

    CPC分类号： B01J13/22 ,  Y10T428/2984 ,  Y10T428/2989 ,  Y10T428/2991

    摘要： The present disclosure relates to a microcapsule and a method of forming a microcapsule which may be used for oxygen sensitive materials. The microcapsule may comprise a shell encapsulating a core material having a surface, wherein the shell comprises a first organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges. This may then be followed by forming a first layer comprising an inorganic or organic polyelectrolyte on the microcapsule surface, where the polyelectrolyte of the first layer provides a plurality of cationic or anionic charges, opposite to the charge of the shell polyelectrolyte. This may then be followed by forming a second layer comprising a second organic or inorganic polyelectrolyte providing a plurality of cationic or anionic charges, opposite to the charge of the first layer polyelectrolyte.

    摘要翻译： 本发明涉及微胶囊和形成可用于氧敏感材料的微胶囊的方法。 微胶囊可以包括包封具有表面的芯材的壳，其中壳包含提供多个阳离子或阴离子电荷的第一有机或无机聚电解质。 然后可以在微胶囊表面上形成包含无机或有机聚电解质的第一层，其中第一层的聚电解质提供与壳聚电解质电荷相反的多个阳离子或阴离子电荷。 然后可以随后形成包含第二有机或无机聚电解质的第二层，其提供与第一层聚电解质的电荷相反的多个阳离子或阴离子电荷。

    Microencapsulation of oxygen or water sensitive materials
    8.
    发明授权
    Microencapsulation of oxygen or water sensitive materials 有权
    氧气或水敏感材料的微胶囊化

    公开(公告)号：US07794836B2

    公开(公告)日：2010-09-14

    申请号：US10654422

    申请日：2003-09-04

    申请人： Niraj Vasishtha ,  Herman W. Schlameus ,  Darren E. Barlow

    发明人： Niraj Vasishtha ,  Herman W. Schlameus ,  Darren E. Barlow

    IPC分类号： A61K9/50 ,  B01J13/00 ,  A61J3/07

    CPC分类号： B01J13/08 ,  A23P10/30 ,  A23P20/20 ,  B01J13/02 ,  B01J13/04 ,  B01J13/10 ,  Y10T428/2985 ,  Y10T428/2989 ,  Y10T428/2991

    摘要： A barrier coating composition includes a polymer material and a structuring agent dispersed in said polymer material, wherein the structuring agent decreases oxygen or water permeability through the polymer material. The barrier coating composition can be used to coat a core component, which can be oxygen or water sensitive, to form a microencapsulated material. The microencapsulated material can be formed by microencapsulation methods, which include atomization or coacervation methods, including forming an oil emulsion of an oil phase and an aqueous phase, the oil phase including the core component and the aqueous phase including the polymer material, adding the structuring agent to one of the oil phase and the aqueous phase, mixing the oil emulsion to form desired particle sizes of the core component, forming the shell component around the core component to form the microencapsulated material, and extracting the formed microencapsulated material from the oil emulsion.

    摘要翻译： 阻隔涂层组合物包括分散在所述聚合物材料中的聚合物材料和结构化剂，其中所述结构剂通过所述聚合物材料降低氧气或水的渗透性。 阻挡涂层组合物可用于涂覆可以是氧或水敏感的核心组分以形成微胶囊化材料。 微胶囊化材料可以通过包括雾化或凝聚方法在内的微囊化方法形成，包括形成油相和水相的油乳液，所述油相包括核心组分和包含聚合物材料的水相，添加结构化 将其与油相和水相之一混合，将油乳液混合以形成所需粒径的核心组分，在芯组分周围形成壳组分以形成微囊化材料，并从油乳液中提取形成的微胶囊化材料 。

    Multi-Disk Spinning Disk Assembly For Atomization and Encapsulation
    9.
    发明申请
    Multi-Disk Spinning Disk Assembly For Atomization and Encapsulation 审中-公开
    用于雾化和封装的多盘旋转磁盘组件

    公开(公告)号：US20160375420A1

    公开(公告)日：2016-12-29

    申请号：US14752420

    申请日：2015-06-26

    申请人： Albert M. Zwiener ,  Darren E. Barlow ,  Mark R. Heistand ,  George T. Lamberson ,  Jeffrey N. Harris

    发明人： Albert M. Zwiener ,  Darren E. Barlow ,  Mark R. Heistand ,  George T. Lamberson ,  Jeffrey N. Harris

    IPC分类号： B01J13/04

    CPC分类号： B01J13/04

    摘要： A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

    摘要翻译： 用于雾化和封装应用的多盘旋转磁盘组件。 堆叠多个磁盘17a和间隔件（33,40）以形成在堆叠的中心磁芯中具有进料井31的磁盘堆叠17。 要被雾化或包封的流体被输送到进料井31.然后流体在隔离物的表面内或表面上流入隔离通道（37,41）。 通道（37,41）将流体朝向盘17a的外边缘传送。 通过间隔件（33,40）的盘表面可以具有各种构造，例如齿，堰或更大或更小的直径，如特定的雾化或包封特性所要求的。