知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.014 秒)

    Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
    1.
    发明授权
    Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents 有权
    制备含有药物活性剂的可生物降解的微粒制剂的方法

    公开(公告)号：US07758778B2

    公开(公告)日：2010-07-20

    申请号：US11220430

    申请日：2005-09-07

    申请人： Joseph T. Persyn ,  Joseph A. McDonough ,  Neal K. Vail ,  Darren E. Barlow ,  Albert M. Zwiener ,  Eliot M. Slovin

    发明人： Joseph T. Persyn ,  Joseph A. McDonough ,  Neal K. Vail ,  Darren E. Barlow ,  Albert M. Zwiener ,  Eliot M. Slovin

    IPC分类号： B29B9/00 ,  A61J3/00

    CPC分类号： B01J13/04 ,  A61K9/1682 ,  A61K9/5089

    摘要： This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

    摘要翻译： 本发明涉及一种用于生产包含药理活性剂和可生物降解聚合物的微粒的装置和方法。 该装置包括在其中心包含储存器的旋转盘和平坦的倾斜表面。 该装置可选地包括锯齿状和/或平行于盘的旋转轴线的圆周周围的平坦表面。 本发明还涉及使用旋转圆盘装置的含有药理活性剂的微粒的制造方法。 提供含有眼科活性剂的制剂。 还描述了显示零级释放速率的制剂。

    Multi-Disk Spinning Disk Assembly For Atomization and Encapsulation
    2.
    发明申请
    Multi-Disk Spinning Disk Assembly For Atomization and Encapsulation 审中-公开
    用于雾化和封装的多盘旋转磁盘组件

    公开(公告)号：US20160375420A1

    公开(公告)日：2016-12-29

    申请号：US14752420

    申请日：2015-06-26

    申请人： Albert M. Zwiener ,  Darren E. Barlow ,  Mark R. Heistand ,  George T. Lamberson ,  Jeffrey N. Harris

    发明人： Albert M. Zwiener ,  Darren E. Barlow ,  Mark R. Heistand ,  George T. Lamberson ,  Jeffrey N. Harris

    IPC分类号： B01J13/04

    CPC分类号： B01J13/04

    摘要： A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

    摘要翻译： 用于雾化和封装应用的多盘旋转磁盘组件。 堆叠多个磁盘17a和间隔件（33,40）以形成在堆叠的中心磁芯中具有进料井31的磁盘堆叠17。 要被雾化或包封的流体被输送到进料井31.然后流体在隔离物的表面内或表面上流入隔离通道（37,41）。 通道（37,41）将流体朝向盘17a的外边缘传送。 通过间隔件（33,40）的盘表面可以具有各种构造，例如齿，堰或更大或更小的直径，如特定的雾化或包封特性所要求的。