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    ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS
    2.
    发明申请
    ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS 有权

    公开(公告)号：US20220087578A1

    公开(公告)日：2022-03-24

    申请号：US17542655

    申请日：2021-12-06

    申请人： Medtronic MiniMed, Inc.

    发明人： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66 ,  A61M5/172

    摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

    Orthogonally redundant sensor systems and methods
    3.
    发明授权
    Orthogonally redundant sensor systems and methods 有权

    公开(公告)号：US10194845B2

    公开(公告)日：2019-02-05

    申请号：US15474535

    申请日：2017-03-30

    申请人： MEDTRONIC MINIMED, INC.

    发明人： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66 ,  A61M5/172

    摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

    USING A BLUE-SHIFTED REFERENCE DYE IN AN OPTICAL GLUCOSE ASSAY
    4.
    发明申请
    USING A BLUE-SHIFTED REFERENCE DYE IN AN OPTICAL GLUCOSE ASSAY 审中-公开

    公开(公告)号：US20180311383A1

    公开(公告)日：2018-11-01

    申请号：US15581540

    申请日：2017-04-28

    申请人： Medtronic MiniMed, Inc.

    发明人： Soren Aasmul ,  Jesper Svenning Kristensen

    IPC分类号： A61K49/00 ,  G01N33/66

    摘要： The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.

    PROTECTIVE AGENTS AGAINST E-BEAM IRRADIATION FOR PROTEINS IN OPTICAL SENSING CHEMISTRY
    5.
    发明申请
    PROTECTIVE AGENTS AGAINST E-BEAM IRRADIATION FOR PROTEINS IN OPTICAL SENSING CHEMISTRY 审中-公开
    光电感应化学品蛋白质电子束辐照保护剂

    公开(公告)号：US20160354500A1

    公开(公告)日：2016-12-08

    申请号：US14728442

    申请日：2015-06-02

    申请人： Medtronic MiniMed, Inc.

    发明人： Tri T. Dang ,  Sarkis Aroyan ,  Jesper Svenning Kristensen

    IPC分类号： A61L2/08 ,  G01N33/66

    CPC分类号： A61L2/087 ,  A61L2202/24 ,  C12Q1/006 ,  G01N33/66 ,  G01N2400/00

    摘要： Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

    摘要翻译： 医疗器械通常在用于制造这种产品的方法中灭菌，并且通过暴露于辐射而进行灭菌是常见的做法。 辐射与其他灭菌方法相比具有许多优点，包括高穿透能力，相对低的化学反应性和瞬时效应，而不需要控制温度，压力，真空或湿度。 不幸的是，辐射灭菌可能危及医疗器械某些部件的功能。 例如，辐射灭菌可导致蛋白质活性的丧失和/或导致各种染料化合物的漂白。 本发明的实施例提供了可用于保护医疗装置免受辐射灭菌不期望的影响的方法和材料。

    Orthogonally redundant sensor systems and methods
    8.
    发明授权
    Orthogonally redundant sensor systems and methods 有权

    公开(公告)号：US11229384B2

    公开(公告)日：2022-01-25

    申请号：US16203951

    申请日：2018-11-29

    申请人： MEDTRONIC MINIMED, INC.

    发明人： Rajiv Shah ,  Jesper Svenning Kristensen ,  Katherine T. Wolfe ,  Soren Aasmul ,  Anubhuti Bansal

    IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/1473 ,  G01N21/64 ,  G01N21/77 ,  G01N33/66 ,  A61M5/172

    摘要： A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body.

    AQUEOUS RADIATION PROTECTING FORMULATIONS AND METHODS FOR MAKING AND USING THEM
    10.
    发明申请
    AQUEOUS RADIATION PROTECTING FORMULATIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
    水质辐射防护配方及其使用方法

    公开(公告)号：US20150174275A1

    公开(公告)日：2015-06-25

    申请号：US14639767

    申请日：2015-03-05

    申请人： Medtronic MiniMed, Inc.

    发明人： Jesper Svenning Kristensen ,  Soren Aasmul

    IPC分类号： A61L2/08 ,  G01N33/53

    CPC分类号： A61L2/087 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14735 ,  A61B5/14865 ,  A61B2562/12 ,  A61B2562/18 ,  A61L2/02 ,  A61L2/081 ,  A61L2202/14 ,  A61L2202/24 ,  G01N33/5308 ,  G01N2400/00 ,  G01N2458/00 ,  Y10T436/14 ,  Y10T436/142222 ,  Y10T436/143333 ,  Y10T436/144444

    摘要： Medical devices are typically sterilized in processes used to manufacture such products and their sterilization by exposure to radiation is a common practice. Radiation has a number of advantages over other sterilization processes including a high penetrating ability, relatively low chemical reactivity, and instantaneous effects without the need to control temperature, pressure, vacuum, or humidity. Unfortunately, radiation sterilization can compromise the function of certain components of medical devices. For example, radiation sterilization can lead to loss of protein activity and/or lead to bleaching of various dye compounds. Embodiments of the invention provide methods and materials that can be used to protect medical devices from unwanted effects of radiation sterilization.

    摘要翻译： 医疗器械通常在用于制造这种产品的方法中灭菌，并且通过暴露于辐射而进行灭菌是常见的做法。 辐射与其他灭菌方法相比具有许多优点，包括高穿透能力，相对低的化学反应性和瞬时效应，而不需要控制温度，压力，真空或湿度。 不幸的是，辐射灭菌可能危及医疗器械某些部件的功能。 例如，辐射灭菌可导致蛋白质活性的丧失和/或导致各种染料化合物的漂白。 本发明的实施例提供了可用于保护医疗装置免受辐射灭菌不期望的影响的方法和材料。