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公开(公告)号：US10543288B2
公开(公告)日：2020-01-28
申请号：US15581416
申请日：2017-04-28
IPC分类号： A61K49/00
摘要： The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.
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公开(公告)号：US20200171173A1
公开(公告)日：2020-06-04
申请号：US16720299
申请日：2019-12-19
IPC分类号： A61K49/00 , G01N33/66 , C08B37/02 , G01N33/542 , C08L5/02
摘要： The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.
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公开(公告)号：US20180311382A1
公开(公告)日：2018-11-01
申请号：US15581416
申请日：2017-04-28
IPC分类号： A61K49/00
摘要： The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore.
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