公开(公告)号：US11963714B2

公开(公告)日：2024-04-23

申请号：US17347179

申请日：2021-06-14

Applicant: Medtronic Ireland Manufacturing Unlimited Company

Inventor： Mark E. Deem ,  Hanson S. Gifford, III ,  Denise Zarins ,  Douglas Sutton ,  Erik Thai ,  Mark Gelfand ,  Howard R. Levin

IPC: A61B18/14 ,  A61B8/08 ,  A61B8/12 ,  A61B18/00 ,  A61B18/12 ,  A61B18/18 ,  A61M5/14 ,  A61M25/00 ,  A61N1/04 ,  A61N1/05 ,  A61N1/18 ,  A61N1/20 ,  A61N1/32 ,  A61N1/36 ,  A61N5/00 ,  A61N7/00

CPC classification number: A61B18/1492 ,  A61B8/0891 ,  A61B8/12 ,  A61B18/1206 ,  A61B18/1233 ,  A61B18/18 ,  A61M5/14 ,  A61M25/0023 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/18 ,  A61N1/205 ,  A61N1/327 ,  A61N1/36007 ,  A61N1/36017 ,  A61N1/36057 ,  A61N1/36103 ,  A61N1/36114 ,  A61N1/36139 ,  A61N5/00 ,  A61N7/00 ,  A61B2018/00071 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00505 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00613 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61B2018/126 ,  A61B2018/1467 ,  A61N1/0412 ,  A61N1/326 ,  A61N1/36117 ,  A61N2007/0021 ,  A61N2007/003

Abstract: Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.