-
公开(公告)号：US11771650B2
公开(公告)日：2023-10-03
申请号：US17127472
申请日：2020-12-18
Applicant: McMaster University
Inventor： Maikel C. Rheinstädter , Sebastian Himbert , Matthew Blacker
CPC classification number: A61K9/1271 , A61K9/1277 , A61K35/18
Abstract: Described herein is a hybrid biological membrane comprising an endogenous bilayer doped with one or more synthetic lipid molecules. Also described herein is a method of preparing a hybrid biological membrane, the method comprising doping an endogenous bilayer with one or more synthetic lipid molecules.
-
公开(公告)号：US20230390200A1
公开(公告)日：2023-12-07
申请号：US18235980
申请日：2023-08-21
Applicant: McMaster University
Inventor： Maikel C. Rheinstädter , Sebastian Himbert , Matthew Blacker
CPC classification number: A61K9/1271 , A61K9/1277 , A61K35/18
Abstract: Described herein is a hybrid biological membrane comprising an endogenous bilayer doped with one or more synthetic lipid molecules. Also described herein is a method of preparing a hybrid biological membrane, the method comprising doping an endogenous bilayer with one or more synthetic lipid molecules.
-
Patent Agency Ranking
公开(公告)号：US20190195867A1
公开(公告)日：2019-06-27
申请号：US16229487
申请日：2018-12-21
Applicant: McMaster University
Inventor： Maikel Rheinstadter , Sebastian Himbert , Richard Alsop , Jose Moran-Mirabal , Sokunthearath Saem , Dawn Bowdish
IPC: G01N33/543 , G01N27/327 , G01N33/53
CPC classification number: G01N33/543 , G01N27/3272 , G01N33/5306
Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.
-
公开(公告)号：US20250041235A1
公开(公告)日：2025-02-06
申请号：US18286732
申请日：2022-04-13
Applicant: McMaster University
Inventor： Maikel Rheinstadter , Sebastian Himbert , Isabella Passos-Gastaldo , Hannah Krivic , Margaret Fahnestock
Abstract: Described herein is a functionalized biological membrane comprising an endogenous bilayer and one or more modifying protein molecules embedded therein or attached thereto. Also described herein is a method of preparing a functionalized biological membrane comprising one or more modifying protein molecules embedded therein or attached thereto, and methods of use and uses of said functionalized biological membranes.
-
公开(公告)号：US20230158507A1
公开(公告)日：2023-05-25
申请号：US18097781
申请日：2023-01-17
Applicant: McMaster University
Inventor： Sebastian Himbert , Maikel Rheinstadter
IPC: B01L3/00 , G01N27/327 , G01N33/53 , G01N33/49
CPC classification number: B01L3/5085 , B01L3/502715 , G01N27/3272 , G01N33/5306 , G01N27/3277 , G01N33/49 , G01N27/3275
Abstract: Provided herein is a biosensor suitable for use in measuring membrane fluidity or membrane permeability. The biosensor is formed of a solid substrate having a lipid bilayer compatible surface and a multi-lamellar lipid membrane structure localized on the lipid bilayer compatible surface. The multi-lamellar lipid membrane structure can be derived from a biological cell further comprising one or more synthetic lipids. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the lipid membrane structure and hemolytic activity in a test sample.
-
公开(公告)号：US11577248B2
公开(公告)日：2023-02-14
申请号：US16229487
申请日：2018-12-21
Applicant: McMaster University
Inventor： Maikel Rheinstadter , Sebastian Himbert , Richard Alsop , Jose Moran-Mirabal , Sokunthearath Saem , Dawn Bowdish
IPC: B01L3/00 , G01N33/53 , G01N27/327 , G01N33/49
Abstract: A biosensor detector device is disclosed suitable for use in measuring membrane fluidity or membrane permeability. The biosensor detector device is formed of a solid substrate having a lipid bilayer compatible surface, a multi-lamellar lipid membrane structure derived from a biological cell and localized on the lipid bilayer compatible surface, an aqueous layer interposed between each lipid bilayer of the multi-lamellar lipid membrane structure. The biological membrane is derived from human red blood cells and localized on the lipid bilayer compatible surface. An electrode forming all or part of the lipid bilayer compatible surface may be used to detect disruptions in the multi-lamellar lipid membrane structure and hemolytic activity in a test sample.
-
公开(公告)号：US20210205218A1
公开(公告)日：2021-07-08
申请号：US17127472
申请日：2020-12-18
Applicant: Mcmaster University
Inventor： Maikel C. Rheinstädter , Sebastian Himbert , Matthew Blacker
Abstract: Described herein is a hybrid biological membrane comprising an endogenous bilayer doped with one or more synthetic lipid molecules. Also described herein is a method of preparing a hybrid biological membrane, the method comprising doping an endogenous bilayer with one or more synthetic lipid molecules.
-
-
-
-
-
-
Search Results
7
records
(took 0.017 seconds)
