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1.发明申请公开(公告)号：US20180179281A1
公开(公告)日：2018-06-28
申请号：US15890048
申请日：2018-02-06
发明人： Lieping Chen , Scott E. Strome , Eugene D. Kwon
IPC分类号： C07K16/28 , G01N33/574 , A61K38/20 , G01N33/569 , G01N33/50 , A61K38/21 , C12Q1/6886 , C12N15/113 , C07K16/30 , A61K39/00
CPC分类号： C07K16/2803 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/215 , A61K38/217 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5088 , G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N33/57438 , G01N33/57484
摘要： The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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公开(公告)号：US20160176967A1
公开(公告)日：2016-06-23
申请号：US15054385
申请日：2016-02-26
IPC分类号： C07K16/28 , C12N15/113
CPC分类号： C07K16/2803 , A61K35/17 , A61K45/00 , C07K14/70532 , C07K2317/76 , C07K2319/00 , C12N15/1138 , C12N2310/14
摘要： This document provides methods and materials involved in treating cancer. For example, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells having the potential to exert anti-cancer effects are provided. In addition, methods and materials for identifying a mammal as having an elevated level of PD-1+/CD11ahigh CD8 T cells and administering a PD-1 inhibitor to such a mammal are provided.
摘要翻译： 本文件提供了治疗癌症的方法和材料。 例如，提供了用于鉴定哺乳动物具有升高水平的具有发挥抗癌作用的潜力的PD-1 + / CD11high CD8T细胞的方法和材料。 另外，提供了用于鉴定哺乳动物具有升高水平的PD-1 + / CD11High CD8T细胞并向这种哺乳动物施用PD-1抑制剂的方法和材料。
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公开(公告)号：US20210380690A1
公开(公告)日：2021-12-09
申请号：US17402262
申请日：2021-08-13
发明人： Lieping Chen , Scott E. Strome , Eugene D. Kwon
IPC分类号： C07K16/28 , C12N15/113 , C12Q1/6886 , G01N33/50 , G01N33/569 , G01N33/574 , A61K38/20 , A61K38/21 , C07K16/30
摘要： The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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公开(公告)号：US09803015B2
公开(公告)日：2017-10-31
申请号：US15047445
申请日：2016-02-18
发明人： Lieping Chen , Scott E. Strome , Eugene D. Kwon
IPC分类号： C07K16/28 , C12N15/113 , C12Q1/68 , G01N33/50 , G01N33/569 , G01N33/574 , A61K38/20 , A61K38/21 , C07K16/30 , A61K39/00
CPC分类号： C07K16/2803 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/215 , A61K38/217 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5088 , G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N33/57438 , G01N33/57484
摘要： The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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公开(公告)号：US20160051675A1
公开(公告)日：2016-02-25
申请号：US14840296
申请日：2015-08-31
发明人： Eugene D. Kwon , John C. Cheville
IPC分类号： A61K39/395 , C07K16/28 , G01N33/574 , C12N15/113 , A61K45/06
CPC分类号： A61K39/39558 , A61K38/19 , A61K38/39 , A61K38/484 , A61K45/06 , C07K16/2827 , C07K2317/76 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , G01N33/57484 , G01N33/57492 , G01N2333/70532 , A61K2300/00
摘要： Methods of evaluating patients by assessing expression of B7-H4 in the vasculature are described.
摘要翻译： 描述了通过评估脉管系统中B7-H4的表达来评价患者的方法。
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公开(公告)号：US20140329248A1
公开(公告)日：2014-11-06
申请号：US14328367
申请日：2014-07-10
发明人： Eugene D. Kwon , John C. Cheville , Amy Krambeck , Susan M. Harrington , Robert H. Thompson , Haidong Dong , Christine M. Lohse , Alexander S. Parker
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , G01N33/57438 , G01N33/57484 , G01N33/57496 , G01N2333/705 , G01N2510/00
摘要： Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.
摘要翻译： 通过评估B7-H1和survivin组合的表达来确定患有癌症的受试者的预后的方法。
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公开(公告)号：US20200326344A1
公开(公告)日：2020-10-15
申请号：US16827487
申请日：2020-03-23
IPC分类号： G01N33/574
摘要： This document features methods of evaluating mammals by assessing expression of B7-H1 in a body fluid.
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8.发明申请公开(公告)号：US20180100015A1
公开(公告)日：2018-04-12
申请号：US15719750
申请日：2017-09-29
发明人： Lieping Chen , Scott E. Strome , Eugene D. Kwon
IPC分类号： C07K16/28 , G01N33/574 , A61K38/20 , G01N33/569 , G01N33/50 , A61K38/21 , C12N15/113 , C07K16/30 , A61K39/00
CPC分类号： C07K16/2803 , A61K38/2013 , A61K38/2026 , A61K38/2066 , A61K38/208 , A61K38/2086 , A61K38/212 , A61K38/215 , A61K38/217 , A61K2039/505 , C07K16/2827 , C07K16/30 , C07K2317/24 , C07K2317/76 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/5088 , G01N33/5091 , G01N33/56972 , G01N33/57407 , G01N33/57438 , G01N33/57484
摘要： The invention features methods of diagnosis by assessing B7-H1 expression in a tissue from a subject that has, or is suspected of having, cancer, methods of treatment with agents that interfere with B7-H1-receptor interaction, methods of selecting candidate subjects likely to benefit from cancer immunotherapy, and methods of inhibiting expression of B7-H1.
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9.发明申请公开(公告)号：US20160251437A1
公开(公告)日：2016-09-01
申请号：US15026461
申请日：2014-09-03
IPC分类号： C07K16/28 , G01N33/574 , C12Q1/68
CPC分类号： C07K16/2827 , A61K2039/505 , C07K16/2818 , C07K2317/76 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57484 , G01N2333/47 , G01N2800/52
摘要： Materials and methods for treating cancer especially in patients identified as having elevated levels of Bim are disclosed. Specifically, the disclosure provides a method for treating a mammal having cancer, the method comprises: (a) identifying said mammal as containing an elevated level of Bim, and (b) administering to said mammal an anti-B7-H1 antibody, an anti-PD-1 antibody, an anti-CD80 antibody, or a fusion protein comprising a portion of PD 1 or a portion of CD80, under conditions wherein the interaction of naturally occurring B7-H1 with PD-1 or CD80 in said mammal is reduced after said administering.
摘要翻译： 公开了用于治疗癌症的材料和方法，特别是在鉴定为具有升高的Bim水平的患者中。 具体地说，本发明提供了一种治疗患有癌症的哺乳动物的方法，所述方法包括：（a）鉴定所述哺乳动物含有升高水平的Bim，和（b）向所述哺乳动物施用抗B7-H1抗体， -PD-1抗体，抗-CD80抗体或包含PD1部分或部分CD80的融合蛋白，在所述哺乳动物中天然存在的B7-H1与PD-1或CD80的相互作用减少的条件下 治疗后。
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公开(公告)号：US20160154000A1
公开(公告)日：2016-06-02
申请号：US15019548
申请日：2016-02-09
发明人： Eugene D. Kwon , John C. Cheville , Amy Krambeck , Susan M. Harrington , Robert H. Thompson , Haidong Dong , Christine M. Lohse , Alexander S. Parker
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , G01N33/57438 , G01N33/57484 , G01N33/57496 , G01N2333/705 , G01N2510/00
摘要： Methods of determining prognosis of a subject with cancer by assessing expression of B7-H1 and survivin in combination.
摘要翻译： 通过评估B7-H1和survivin组合的表达来确定患有癌症的受试者的预后的方法。
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