公开(公告)号：US20060266211A1

公开(公告)日：2006-11-30

申请号：US11440636

申请日：2006-05-25

Applicant: Bruce Larkin ,  Joseph Kovach ,  Matthew Simon ,  Eric Chapman ,  Dan Nguyen

Inventor： Bruce Larkin ,  Joseph Kovach ,  Matthew Simon ,  Eric Chapman ,  Dan Nguyen

IPC: F01B31/12

CPC classification number: F04B1/2014 ,  F04B2201/12051 ,  G01D5/34776

Abstract: In a variable displacement type hydraulic pump/motor assembly including at least one internally movable component, such as a yoke, a swashplate, and the means for moving the swashplate, the improvement includes imparting on this component absolute location indicia markings and the addition of an optical/electronic sensor unit capable of reading such indicia markings fixedly located on a housing of the pump/motor assembly and including an optical read head extending into the housing interior and located at a spaced distance from the indicia markings for reading same, relative to a reference location, and producing a signal indicative of the absolute position of the movable component. The signal can then, in turn, be used for controlling the displacement of the pump/motor assembly. A method for determining the absolute component position is also set forth.

Abstract translation: 在包括至少一个内部可移动部件（例如轭架，斜盘）和用于移动斜盘的装置的可变排量型液压泵/电动机组件中，改进包括赋予该部件绝对位置标记标记和添加 光学/电子传感器单元，其能够读取固定地位于泵/马达组件的壳体上的标记标记，并且包括延伸到壳体内部并位于与标记标记间隔开的位置处的光学读取头，用于相对于 并产生指示可移动部件的绝对位置的信号。 然后，信号又可以用于控制泵/马达组件的位移。 还阐述了确定绝对分量位置的方法。

公开(公告)号：US20060016184A1

公开(公告)日：2006-01-26

申请号：US11113947

申请日：2005-04-25

Applicant: Matthew Simon

Inventor： Matthew Simon

IPC: F16D31/02

CPC classification number: F15B1/26 ,  Y10S60/912 ,  Y10S165/916

Abstract: Improvement, in hydraulic systems, such as for vehicle transmissions and the like, in the form of a hydraulic reservoir with integrated heat exchanger having fluid supply/return and fluid return ports, including a central section, having inner and outer shell portions with a first gap therebetween, the outer shell being provided with a plurality of radially-spaced, external cooling fins, longitudinally-directed for the length of the central section; the ends of the latter being closed off via respective bottom and top cap portions, thereby defining a central fluid cavity, the top cap portion having spaced outer and inner cap portions, with a second gap therebetween, with a fluid inlet port, in the outer cap portion, directing incoming fluid from the second gap into and through the entire length of the first gap before entering the central fluid cavity, thereby maximizing heat transfer from the fluid via the plurality of cooling fins.

Abstract translation: 在具有集成热交换器的液压储存器的液压系统中，诸如用于车辆变速器等的改进，具有流体供应/返回和流体返回端​​口，包括中心部分，其具有内部和外部壳体部分，其具有第一 所述外壳设置有多个径向间隔开的外部冷却翅片，所述多个径向隔开的外部冷却翅片沿着所述中心部分的长度纵向定向; 后端的端部经由相应的底部和顶部盖部分封闭，从而限定中心流体腔，顶盖部分具有间隔的外部和内部盖部分，其间具有第二间隙，在外部具有流体入口端口 帽部分，在进入中心流体腔之前将进入的流体从第二间隙引导入并穿过第一间隙的整个长度，从而最大化通过多个冷却翅片从流体传热。

公开(公告)号：US06394736B1

公开(公告)日：2002-05-28

申请号：US09469380

申请日：1999-12-22

Applicant: Stephen Derby ,  Matthew Simon ,  Mark Allen

Inventor： Stephen Derby ,  Matthew Simon ,  Mark Allen

IPC: B65G6523

CPC classification number: B65G65/23

Abstract: A Bulk Mail Container (BMC) unloader uses a simple crossed four bar-linkage to move a predetermined point on a BMC unloader in a substantially straight line while the overall BMC unloader rotates about that predetermined point so as to upend the BMC container. This takes advantage of the crossed four-bar's substantially straight-line motion over a limited range of its motion, as well as the rotational motion of the particular unloader link disclosed herein. This is advantageous for unloading. In use, a BMC container is simply rolled into the BMC unloader, and the entire combination of the BMC container and BMC unloader is then actuated to produce substantially straight line motion along a suitably selected “center” point of the BMC unloader while the overall combination rotates about the center point so as to upend the BMC for unloading.

Abstract translation: 散装邮件集装箱（BMC）卸载机使用简单的交叉四杆连杆机构在大致直线上移动BMC卸载机上的预定点，同时整个BMC卸载机围绕该预定点旋转，以便升高BMC容器。 这有利于在其运动的有限范围内交叉的四杆的基本直线运动以及本文公开的特定卸载器连杆的旋转运动。 这对卸载是有利的。 在使用中，将BMC容器简单地卷入BMC卸载机，然后启动BMC容器和BMC卸载机的整个组合，以沿着BMC卸载机的适当选择的“中心”点产生基本上直线运动，而整体组合 围绕中心点旋转，以便抬起BMC进行卸载。

公开(公告)号：US10273529B2

公开(公告)日：2019-04-30

申请号：US14239369

申请日：2012-08-20

Applicant: Robert Kingston ,  Matthew Simon ,  Jason Allen West

Inventor： Robert Kingston ,  Matthew Simon ,  Jason Allen West

IPC: C12Q1/68 ,  C12Q1/6834 ,  C12Q1/6813 ,  C12Q1/6876 ,  C12Q1/6809 ,  C12Q1/6811

Abstract: Methods and assays are provided for isolating factors including polypeptides, ribonucleic acids (RNAs) and polypeptide complexes that are associated with a target nucleic acid sequence. The target nucleic acid sequence may be comprised within chromatin. The methods are suitable for identification and characterisation of factors including non-coding RNAs (ncRNAs) that associate with specified genomic loci.

公开(公告)号：US20110010364A1

公开(公告)日：2011-01-13

申请号：US12797398

申请日：2010-06-09

Applicant: Marko Ahtisaari ,  Matthew Simon

Inventor： Marko Ahtisaari ,  Matthew Simon

IPC: G06F17/30

CPC classification number: G06Q50/10 ,  G06F16/9535 ,  G06Q50/14

Abstract: A location database is maintained with information regarding each of a number of different geographical items in different locations. A user database is also maintained with user records for various users, each user record comprising the user's identification data. In addition, in at least one of the location database and the user database, an identification is maintained of different geographical items which each user has visited. Geographical-item-to-geographical-item similarities are defined between different geographical items based on the user database. User-to-user similarities between the users are defined based on the user database. A weighted combination of the defined geographical-item-to-geographical-item and user-to-user similarities is computed and particularly relevant geographical items in a given location are identified to a user based on the weighted combination.

Abstract translation: 使用关于不同位置中的多个不同地理项目中的每一个的信息来维护位置数据库。 用户数据库还用各种用户的用户记录进行维护，每个用户记录包括用户的识别数据。 此外，在位置数据库和用户数据库中的至少一个中，维护每个用户已访问的不同地理项目的标识。 基于用户数据库，在不同地理项目之间定义地理项目到地理项目的相似性。 基于用户数据库定义用户与用户之间的相似之处。 计算定义的地理项目到地理项目和用户与用户相似性的加权组合，并且基于加权组合向用户识别给定位置中的特定相关地理项目。

公开(公告)号：US20120040857A1

公开(公告)日：2012-02-16

申请号：US13201476

申请日：2010-02-12

Applicant: Robert Kingston ,  Jerome Dejardin ,  Matthew Simon

Inventor： Robert Kingston ,  Jerome Dejardin ,  Matthew Simon

IPC: C40B30/04 ,  C07H21/04 ,  C07H1/06 ,  C07K2/00 ,  C12Q1/68 ,  C07H21/02

CPC classification number: C12N15/111 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2320/12

Abstract: Methods for isolating non-coding nucleic acids that are associated with chromatin at a target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a target genomic DNA sequence and one or more non-coding nucleic acids associated with that DNA sequence; contacting the sample with at least one oligonucleotide probe that comprises a sequence that is complimentary to and capable of hybridising with at least a portion of the target DNA sequence, wherein the oligonucleotide probe comprises at least one modified nucleotide analogue and wherein the oligonucleotide probe further comprises at least one affinity label; allowing the at least one oligonucleotide probe and the target DNA sequence to hybridise with each other so as to form a probe-target hybrid; isolating the probe-target hybrid from the sample by immobilizing the probe-target hybrid through a molecule that binds to the at least one affinity label; and eluting the one or more non-coding nucleic acids that are associated with the target genomic DNA sequence. Also provided are probes suitable for use in the methods of the invention. The methods and probes of the invention are suited to identification of non-coding RNAs including microRNAs and snoRNAs that are associated with chromatin remodelling.

Abstract translation: 提供了在目标基因组座标上分离与染色质相关的非编码核酸的方法。 所述方法包括获得包含目标基因组DNA序列和与该DNA序列相关的一个或多个非编码核酸的样品的步骤; 使样品与至少一种寡核苷酸探针接触，所述寡核苷酸探针包含与至少一部分目标DNA序列互补且能够与目标DNA序列的至少一部分杂交的序列，其中所述寡核苷酸探针包含至少一个修饰的核苷酸类似物，并且其中所述寡核苷酸探针还包含 至少一个亲和标签; 使所述至少一种寡核苷酸探针和所述靶DNA序列彼此杂交以形成探针 - 靶杂交体; 通过将所述探针 - 靶杂交体固定到与所述至少一个亲和标记物结合的分子上来分离所述探针 - 靶杂交物; 并洗脱与目标基因组DNA序列相关联的一个或多个非编码核酸。 还提供了适用于本发明方法的探针。 本发明的方法和探针适用于鉴定与染色质重塑相关的非编码RNA，包括微小RNA和snoRNA。

公开(公告)号：US20150056615A1

公开(公告)日：2015-02-26

申请号：US14239369

申请日：2012-08-20

Applicant: Robert Kingston ,  Matthew Simon ,  Jason Allen West

Inventor： Robert Kingston ,  Matthew Simon ,  Jason Allen West

IPC: C12Q1/68

CPC classification number: C12Q1/6834 ,  C12Q1/6809 ,  C12Q1/6811 ,  C12Q1/6813 ,  C12Q1/6876 ,  C12Q2523/101 ,  C12Q2525/207 ,  C12Q2565/133 ,  C12Q2522/101 ,  C12Q2563/131 ,  C12Q2523/303 ,  C12Q2563/149

Abstract: Methods and assays are provided for isolating factors including polypeptides, ribonucleic acids (RNAs) and polypeptide complexes that are associated with a target nucleic acid sequence. The target nucleic acid sequence may be comprised within chromatin. The methods are suitable for identification and characterisation of factors including non-coding RNAs (ncRNAs) that associate with specified genomic loci.

Abstract translation: 提供了用于分离因子的方法和测定，所述因子包括与靶核酸序列相关的多肽，核糖核酸（RNA）和多肽复合物。 靶核酸序列可以包含在染色质内。 该方法适用于与特定基因组位点相关的非编码RNA（ncRNA）等因素的鉴定和表征。

公开(公告)号：US06565308B2

公开(公告)日：2003-05-20

申请号：US10063831

申请日：2002-05-16

Applicant: Stephen Derby ,  Matthew Simon ,  Mark Allen

Inventor： Stephen Derby ,  Matthew Simon ,  Mark Allen

IPC: B65G6523

CPC classification number: B65G65/23

Abstract: A Bulk Mail Container (BMC) unloader uses a simple crossed four bar-linkage to move a predetermined point on a BMC unloader in a substantially straight line while the overall BMC unloader rotates about that predetermined point so as to upend the BMC container. This takes advantage of the crossed four-bar's substantially straight-line motion over a limited range of its motion, as well as the rotational motion of the particular unloader link disclosed herein. This is advantageous for unloading. In use, a BMC container is simply rolled into the BMC unloader, and the entire combination of the BMC container and BMC unloader is then actuated to produce substantially straight line motion along a suitably selected “center” point of the BMC unloader while the overall combination rotates about the center point so as to upend the BMC for unloading.